Stem cell regulation: Implications when differentiated cells regulate symmetric stem cell division
Journal article, Peer reviewed
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http://hdl.handle.net/11250/2381911Utgivelsesdato
2015-05Metadata
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Originalversjon
Høyem, M.R. et al (2015) Stem cell regulation: Implications when differentiated cells regulate symmetric stem cell division. Journal of Theoretical Biology, 380:203-219 10.1016/j.jtbi.2015.05.009Sammendrag
We use a mathematical model to show that if symmetric stem cell division is regulated by differentiated
cells, then changes in the population dynamics of the differentiated cells can lead to changes in the
population dynamics of the stem cells. More precisely, the relative
fi
tness of the stem cells can be
affected by modifying the death rate of the differentiated cells. This result is interesting because stem
cells are less sensitive than differentiated cells to environmental factors, such as medical therapy. Our
result implies that stem cells can be manipulated indirectly by medical treatments that target the
differentiated cells.
Beskrivelse
Published by Elsevier Ltd. This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).