Blar i Vitenskapelige publikasjoner (TN-IKBM) på forfatter "Fernandes, Miguel X."
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A hybrid of 1-deoxynojirimycin and benzotriazole induces preferential inhibition of butyrylcholinesterase (BuChE) over acetylcholinesterase (AChE)
Evangelista, Tereza Cristina Santos; Lopez, Oscar; Puerta, Adrian; Fernandes, Miguel X.; Ferreira, Sabrina Baptista; Padron, Jose M.; Fernandez-Bolanos, Jose G.; Sydnes, Magne Olav; Lindback, Emil (Peer reviewed; Journal article, 2022)The synthesis of four heterodimers in which the copper(I)-catalysed azide-alkyne cycloaddition was employed to connect a 1-deoxynojirimycin moiety with a benzotriazole scaffold is reported. The heterodimers were investigated ... -
Investigation of the enantioselectivity of acetylcholinesterase and butyrylcholinesterase upon inhibition by tacrine-iminosugar heterodimers
Vaaland, Ingrid Caroline; Lopez, Oscar; Puerta, Adrian; Fernandes, Miguel X.; Padron, Jose M.; Fernandez-Bolanos, Jose G.; Sydnes, Magne Olav; Lindback, Emil (Peer reviewed; Journal article, 2023-09)The copper-catalysed azide-alkyne cycloaddition was applied to prepare three enantiomeric pairs of heterodimers containing a tacrine residue and a 1,4-dideoxy-1,4-imino-D-arabinitol (DAB) or 1,4-dideoxy-1,4-imino-L-arabinitol ...