dc.contributor.advisor | Lindbäck, Emil | |
dc.contributor.author | Bringsjord, Geir Magne Risbakken | |
dc.date.accessioned | 2020-09-29T07:46:12Z | |
dc.date.available | 2020-09-29T07:46:12Z | |
dc.date.issued | 2020-08-10 | |
dc.identifier.uri | https://hdl.handle.net/11250/2680122 | |
dc.description | Master's thesis in biological chemistry | en_US |
dc.description.abstract | This project presents the synthesis of tacrine and coumarin scaffolds armed with an alkyl-chain of varying length with an azido functionality and isocryptolepine scaffold armed with a terminal alkyne.
The synthesis of these compounds lead to the successful synthesis of the potential dual binding site acetylcholinesterase inhibitors, a tacrine-cryptolepine hybrid with a 3 carbon-linker and a coumarin-isocryptolepine hybrid with a 4 carbon-linker assembled via copper-catalyzed azidealkyne cycloaddition (CuAAC). The attempted synthesis of the same hybrids with different linker-length (6 and 8) were not successful. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | University of Stavanger, Norway | en_US |
dc.relation.ispartofseries | Masteroppgave/UIS-TN-IKBM/2020; | |
dc.subject | Alzheimer's disease | en_US |
dc.subject | biologisk kjemi | en_US |
dc.subject | biological chemistry | en_US |
dc.subject | acetylcholinesterase inhibitor | en_US |
dc.title | Synthesis of tacrine- and coumarin-isocryptolepine hybrids as potential dual binding site acetylcholinesterase inhibitors | en_US |
dc.type | Master thesis | en_US |
dc.description.version | submittedVersion | en_US |
dc.rights.holder | Geir Magne Risbakken Bringsjord | en_US |
dc.subject.nsi | VDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470::Biokjemi: 476 | en_US |