Photodegradable Antimicrobial Agents: Synthesis and Mechanism of Degradation
Peer reviewed, Journal article
Published version
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https://hdl.handle.net/11250/3059690Utgivelsesdato
2022Metadata
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Originalversjon
Eikemo, V., Holmelid, B., Sydnes, L. K., & Sydnes, M. O. (2022). Photodegradable Antimicrobial Agents: Synthesis and Mechanism of Degradation. The Journal of Organic Chemistry, 87(12), 8034-8047. 10.1021/acs.joc.2c00681Sammendrag
As a strategy to inactivate antimicrobial agents after use, we designed a range of ethanolamine derivatives where four of them possessed interesting activity. The ethanolamine moiety facilitates photodecomposition, which in a potential drug will take place after use. Herein, the synthetic preparation of these compounds and the mechanism of photoinactivation are described.