dc.contributor.author | Oftedal, Linn Silje Wathne | |
dc.contributor.author | Maple-Gørdem, Jodi | |
dc.contributor.author | Tysnes, Ole-Bjørn | |
dc.contributor.author | Alves, Guido Werner | |
dc.contributor.author | Lange, Johannes | |
dc.date.accessioned | 2024-02-19T12:09:17Z | |
dc.date.available | 2024-02-19T12:09:17Z | |
dc.date.created | 2023-09-26T12:45:35Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Oftedal, L., Maple-Gørdem, J., Tysnes, O. B., Alves, G., & Lange, J. (2023). Seed Amplification Assay as a Diagnostic Tool in Newly-Diagnosed Parkinson’s Disease. Journal of Parkinson's Disease, 13 (5), 841-844. | en_US |
dc.identifier.issn | 1877-7171 | |
dc.identifier.uri | https://hdl.handle.net/11250/3118434 | |
dc.description.abstract | Seed amplification assays (SAA) are the first credible molecular assay for Parkinson’s disease (PD). However, the value of SAA to support the clinicians’ initial diagnosis of PD is not clear. In our study, we analyzed cerebrospinal fluid samples from 121 PD patients recruited through population screening methods and taken within a median delay of 38 days from diagnosis and 51 normal controls without neurodegenerative disease. SAA yielded a sensitivity of 82.6% (95% CI, 74.7% – 88.9%) and specificity of 88.2% (95% CI, 76.1% – 95.6%). These results highlight the potential of SAA to support the initial diagnosis of PD in clinical practice and research. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | IOS Press | |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Seed Amplification Assay as a Diagnostic Tool in Newly-Diagnosed Parkinson's Disease | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | The authors | en_US |
dc.subject.nsi | VDP::Medisinske Fag: 700 | en_US |
dc.source.pagenumber | 841-844 | en_US |
dc.source.volume | 13 | en_US |
dc.source.journal | Journal of Parkinson's Disease | en_US |
dc.source.issue | 5 | en_US |
dc.identifier.doi | 10.3233/JPD-230065 | |
dc.identifier.cristin | 2179010 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |