Self-reported sleep fragmentation and sleep duration and their association with cognitive function in PROTECT, a large digital community-based cohort of people over 50
Aakre, Jon Arild; Schulz, Jörn; Ballard, Clive; Corbett, Anne; Bjorvatn, Bjørn; Aarsland, Dag; Creese, Byron; Hampshire, Adam; Brooker, Helen; Testad, Ingelin
Peer reviewed, Journal article
Published version
Permanent lenke
https://hdl.handle.net/11250/3121942Utgivelsesdato
2023Metadata
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Originalversjon
Aakre, J. A., Schulz, J., Ballard, C., Corbett, A., Bjorvatn, B., Aarsland, D., ... & Testad, I. (2023). Self‐reported sleep fragmentation and sleep duration and their association with cognitive function in PROTECT, a large digital community‐based cohort of people over 50. International Journal of Geriatric Psychiatry, 38(11), e6022. 10.1002/gps.6022Sammendrag
Objective
Sleep is vital for normal cognitive function in daily life, but is commonly disrupted in older adults. Poor sleep can be detrimental to mental and physical health, including cognitive function. This study assessed the association between self-reported short (<6 h) and long (>9 h) sleep duration and sleep fragmentation (3≥ nightly awakenings) in cognitive function.
Methods
Cross-sectional data from 8508 individuals enroled in the PROTECT study aged 50 and above formed the basis of the univariate linear regression analysis conducted on four cognitive outcomes assessing visuospatial episodic memory (VSEM), spatial working memory, verbal working memory (VWM), and verbal reasoning (VR).
Results
Short (ß = −0.153, 95% CI [−0.258, −0.048], p = 0.004) and long sleep duration (ß = −0.459, 95% CI [−0.826, −0.091], p = 0.014) were significantly associated with poorer cognitive performance in VWM. Long sleep duration (ß = −2.986, 95% CI [−5.453, −0.518], p = 0.018) was associated with impaired VR. Short sleep (ß = −0.133, 95% CI [−0.196, −0.069], p = <0.001) and sleep fragmentation (ß = −0.043, 95% CI [−0.085, −0.001], p = 0.043) were associated with reduced VSEM. These associations remained significant when including other established risk factors for dementia and cognitive decline (e.g., depression, hypertension).
Conclusions
Our findings suggest that short and long sleep durations and fragmented sleep, may be risk factors for a decline in cognitive processes such as working memory, VR and episodic memory thus might be potential targets for interventions to maintain cognitive health in ageing.