• Homeostatic controllers compensating for growth and perturbations 

      Ruoff, Peter; Agafonov, Oleg; Tveit, Daniel Myklatun; Thorsen, Kristian; Drengstig, Tormod (Journal article; Peer reviewed, 2019-08)
      Cells and organisms have developed homeostatic mechanisms which protect them against a changing environment. How growth and homeostasis interact is still not well understood, but of increasing interest to the molecular and ...
    • Interleukin-1-related activity and hypocretin-1 in cerebrospinal fluid contribute to fatigue in primary Sjögren's syndrome 

      Bårdsen, Kjetil; Brede, Cato; Kvivik, Ingeborg; Kvaløy, Jan Terje; Jonsdottir, Kristin; Tjensvoll, Anne Bolette; Ruoff, Peter; Omdal, Roald (Peer reviewed; Journal article, 2019)
      Background Fatigue is a common and sometimes debilitating phenomenon in primary Sjögren’s syndrome (pSS) and other chronic inflammatory diseases. We aimed to investigate how IL-1 β-related molecules and the neuropeptide ...
    • Interleukin-1β, heat shock protein 90α, and hypocretin-1 in chronic fatigue 

      Bårdsen, Kjetil (PhD thesis UiS;505, Doctoral thesis, 2020-09)
      Background: Fatigue, defined as an overwhelming sense of tiredness, lack of energy, and feeling of exhaustion, is a phenomenon many people have experienced in connection with infections such as influenza, Epstein-Barr ...
    • Kinetics and mechanisms of catalyzed dual-E (antithetic) controllers 

      Waheed, Qaiser; Zhou, Huimin; Ruoff, Peter (Peer reviewed; Journal article, 2022)
      Homeostasis plays a central role in our understanding how cells and organisms are able to oppose environmental disturbances and thereby maintain an internal stability. During the last two decades there has been an increased ...
    • Life cycle assessment of tomato production for different production strategies in Norway 

      Naseer, Muhammad; Persson, Tomas; Hjelkrem, Anne-Grete Roer; Ruoff, Peter; Verheul, Michel (Peer reviewed; Journal article, 2022)
      The availability of fresh vegetables grown in greenhouses under controlled conditions throughout the year has given rise to concerns about their impact on the environment. In high latitude countries such as Norway, greenhouse ...
    • Listeria monocytogenes in Norwegian fish farms from September to January 

      Zaremba, Sandra (Masteroppgave/UIS-TN-IKBM/2018;, Master thesis, 2018-06)
      The Norwegian food industry is best known for salmon production and distribution to over 70 countries. Salmon processing factories are susceptible to the establishment of the pathogen bacterium Listeria monocytogenes, which ...
    • Matkvalitet på norske brunalger, med fokus på butare (Alaria esculenta) og sukkertare (Saccharina latissima) 

      Jordbrekk Blikra, Marthe (Masteroppgave/UIS-TN-IMN/2016;, Master thesis, 2016-06-15)
      I denne masteroppgaven ble Alaria esculenta (butare) og Saccharina latissima (sukkertare) undersøkt for overordnet kvalitet, med vekt på mikrobiologi, farge og tekstur. Algene ble dyrket og høstet på Værlandet-Bulandet ...
    • Model Development and Investigations on Ion Homeostasis 

      Selstø, Christina Helen (PhD thesis UiS;, Doctoral thesis, 2023-05)
      The environment surrounding an organism, a cell and an organelle is constantly changing. To keep organisms functioning there is an everlasting need to regulate and adapt in order to keep the internal environment relatively ...
    • Next-Generation Biomaterials for Food Packaging Applications 

      Vinningland, Ingrid (Master thesis, 2021)
      During the recent years, environmentally friendly packaging has become increasingly important for the consumer. However, this shift towards a greener alternative should not come as a compromise on the safety of the product ...
    • Performance of Enzyme-Catalyzed Single-E and Dual-E Homeostatic Controllers 

      Huimin, Zhou (Masteroppgave/UIS-TN-IKBM/2020;, Master thesis, 2020-06-15)
      Mathematical modeling has become an important tool in order to investigate the behavior of biological systems. The concept of homeostasis is central to our understanding how cells and organisms maintain an internal stability ...
    • Personalized medicine to improve treatment of dopa-responsive dystonia—a focus on tyrosine hydroxylase deficiency 

      Nygaard, Gyrid; Szigetvari, Peter D.; Grindheim, Ann Kari; Ruoff, Peter; Martinez, Aurora; Haavik, Jan; Kleppe, Rune; Flydal, Marte I. (Peer reviewed; Journal article, 2021-11)
      Dopa-responsive dystonia (DRD) is a rare movement disorder associated with defective dopamine synthesis. This impairment may be due to the fact of a deficiency in GTP cyclohydrolase I (GTPCHI, GCH1 gene), sepiapterin ...
    • PLATINUM SENSITIVE 2 LIKE impacts growth, root morphology, seed set, and stress responses 

      Lillo, Catherine; Kataya, Amr R. A.; Creighton, Maria Terese; Napitupulu, Toga P.; Sætre, Christine; Heidari, Behzad; Ruoff, Peter (Journal article; Peer reviewed, 2017-07)
      Eukaryotic protein phosphatase 4 (PP4) is a PP2A-type protein phosphatase that is part of a conserved complex with regulatory factors PSY2 and PP4R2. Various lines of Arabidopsis thaliana with mutated PP4 subunit genes ...
    • Semi-algebraic optimization of temperature compensation in a general switch-type negative feedback model of circadian clocks 

      Aase, Sven Ole; Ruoff, Peter (Journal article; Peer reviewed, 2008)
      Temperature compensation is an essential property of circadian oscillators which enables them to act as physiological clocks. We have analyzed the temperature compensating behavior of a generalized transcriptional–translational ...
    • Sensitivity analysis of a pathway with respect to fast and small temperature change 

      Zakhartsev, Maksim; Ruoff, Peter (Journal article; Peer reviewed, 2019)
      Temperature affects all enzymes simultaneously in a metabolic system. The enzyme concentration in a biochemical system can be considered as invariant under fast and small temperature change. Therefore, the total sensitivity ...
    • Structural Properties of Biological Integral Feedback Motifs 

      Tveit, Daniel Myklatun (PhD thesis UiS;, Doctoral thesis, 2020-09)
      Cells are exposed to a range of external and internal disturbances that may influence the function of cellular processes. The ability of cells to self-regulate and adapt to disturbances enable them to maintain essential ...
    • The organization of controller motifs leading to robust plant iron homeostasis 

      Agafonov, Oleg; Selstø, Christina Helen; Thorsen, Kristian; Xiang, Ming Xu; Drengstig, Tormod; Ruoff, Peter (Journal article; Peer reviewed, 2016-01)
      Iron is an essential element needed by all organisms for growth and development. Because iron becomes toxic at higher concentrations iron is under homeostatic control. Plants face also the problem that iron in the soil is ...
    • Variable setpoint as a relaxing component in physiological control 

      Risvoll, Geir; Thorsen, Kristian; Ruoff, Peter; Drengstig, Tormod (Journal article; Peer reviewed, 2017-09)
      Setpoints in physiology have been a puzzle for decades, and especially the notion of fixed or variable setpoints have received much attention. In this paper, we show how previously presented homeostatic controller motifs, ...