• Alleviation of C⋅C Mismatches in DNA by the Escherichia coli Fpg Protein 

      Tesfahun, Almaz Nigatu; Alexeeva, Marina; Tomkuvienė, Miglė; Arshad, Aysha; Guragain, Prashanna; Klungland, Arne; Klimašauskas, Saulius; Ruoff, Peter; Bjelland, Svein (Peer reviewed; Journal article, 2021-06)
      DNA polymerase III mis-insertion may, where not corrected by its 3′→ 5′ exonuclease or the mismatch repair (MMR) function, result in all possible non-cognate base pairs in DNA generating base substitutions. The most ...
    • Excision of 5-hydroxymethyluracil in single-stranded DNA by hSMUG1 requires Ser26 and/or Glu35 and Pro240 

      Bærheim, Trond (Master thesis, 2021)
      The integrity of the genetic material of all organisms is assaulted continuously by a multitude of endogenous and exogenous agents throughout its lifetime, where the DNA bases of the genetic code may be altered if not ...
    • hUNG activity for uracil in bubble and R-loop DNA 

      Mehanna, Shimaa (Master thesis, 2021)
      Uracil, a common base in RNA, may arise in cellular DNA by cytosine deamination or during replication through the misincorporation of deoxyuridine monophosphate instead of thymidine monophosphate. Repair of uracil is ...
    • Uracil-excising activity of hSMUG1 in bubble and R-loop DNA 

      Ruales, Cyrell Ann (Master thesis, 2021)
      Uracil arises in cellular DNA by hydrolytic cytosine (C) deamination and by erroneous repli-cative incorporation of deoxyuridine monophosphate opposite adenine. The former event is devastating by generation of C  thymine ...