• Alleviation of C⋅C Mismatches in DNA by the Escherichia coli Fpg Protein 

      Tesfahun, Almaz Nigatu; Alexeeva, Marina; Tomkuvienė, Miglė; Arshad, Aysha; Guragain, Prashanna; Klungland, Arne; Klimašauskas, Saulius; Ruoff, Peter; Bjelland, Svein (Peer reviewed; Journal article, 2021-06)
      DNA polymerase III mis-insertion may, where not corrected by its 3′→ 5′ exonuclease or the mismatch repair (MMR) function, result in all possible non-cognate base pairs in DNA generating base substitutions. The most ...
    • Emerging Role of Epigenetic Alterations as Biomarkers and Novel Targets for Treatments in Pancreatic Ductal Adenocarcinoma 

      Roalsø, Marcus Thomas Thor; Hald, Øyvind; Alexeeva, Marina; Søreide, Kjetil (Peer reviewed; Journal article, 2022-01)
      Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with limited treatment options. Emerging evidence shows that epigenetic alterations are present in PDAC. The changes are potentially reversible and therefore ...
    • The escherichia coli alkA gene is activated to alleviate mutagenesis by an oxidized deoxynucleoside 

      Grøsvik, Kristin; Tesfahun, Almaz Nigatu; Muruzábal-Lecumberri, Izaskun; Haugland, Gyri Teien; Leiros, Ingar; Ruoff, Peter; Kvaløy, Jan Terje; Knævelsrud, Ingeborg; Ånensen, Hilde; Alexeeva, Marina; Sato, Kousuke; Matsuda, Akira; Alseth, Ingrun; Klungland, Arne; Bjelland, Svein (Peer reviewed; Journal article, 2020)
      The cellular methyl donor S-adenosylmethionine (SAM) and other endo/exogenous agents methylate DNA bases non-enzymatically into products interfering with replication and transcription. An important product is 3-methyladenine ...
    • Excision of 5-hydroxymethyluracil in single-stranded DNA by hSMUG1 requires Ser26 and/or Glu35 and Pro240 

      Bærheim, Trond (Master thesis, 2021)
      The integrity of the genetic material of all organisms is assaulted continuously by a multitude of endogenous and exogenous agents throughout its lifetime, where the DNA bases of the genetic code may be altered if not ...
    • hUNG activity for uracil in bubble and R-loop DNA 

      Mehanna, Shimaa (Master thesis, 2021)
      Uracil, a common base in RNA, may arise in cellular DNA by cytosine deamination or during replication through the misincorporation of deoxyuridine monophosphate instead of thymidine monophosphate. Repair of uracil is ...
    • Intrinsic Strand-Incision Activity of Human UNG: Implications for Nick Generation in Immunoglobulin Gene Diversification 

      Alexeeva, Marina; Moen, Marivi Nabong; Xu, Xiang Ming; Rasmussen, Anette; Leiros, Ingar; Kirpekar, Finn; Klungland, Arne; Alsøe, Lene; Nilsen, Hilde; Bjelland, Svein (Peer reviewed; Journal article, 2021)
      Uracil arises in cellular DNA by cytosine (C) deamination and erroneous replicative incorporation of deoxyuridine monophosphate opposite adenine. The former generates C → thymine transition mutations if uracil is not removed ...
    • Uracil-excising activity of hSMUG1 in bubble and R-loop DNA 

      Ruales, Cyrell Ann (Master thesis, 2021)
      Uracil arises in cellular DNA by hydrolytic cytosine (C) deamination and by erroneous repli-cative incorporation of deoxyuridine monophosphate opposite adenine. The former event is devastating by generation of C  thymine ...