Browsing UiS Brage by Author "Bjelland, Svein"

Now showing items 1-10 of 10

    • Alexeeva, M., Moen, M.N., Grøsvik, K. et al (2018) Excision of uracil from DNA by hSMUG1 includes strand incision and processing. 

      Moen, Marivi Nabong; Grøsvik, Kristin; Kirpekar, Finn; Tesfahun, Almaz Nigatu; Ruoff, Peter; Klungland, Arne; Bjelland, Svein (Journal article; Peer reviewed, 2018-11)
      Uracil arises in DNA by hydrolytic deamination of cytosine (C) and by erroneous incorporation of deoxyuridine monophosphate opposite adenine, where the former event is devastating by generation of C → thymine transitions. ...

    • Alleviation of C⋅C Mismatches in DNA by the Escherichia coli Fpg Protein 

      Tesfahun, Almaz Nigatu; Alexeeva, Marina; Tomkuvienė, Miglė; Arshad, Aysha; Guragain, Prashanna; Klungland, Arne; Klimašauskas, Saulius; Ruoff, Peter; Bjelland, Svein (Peer reviewed; Journal article, 2021-06)
      DNA polymerase III mis-insertion may, where not corrected by its 3′→ 5′ exonuclease or the mismatch repair (MMR) function, result in all possible non-cognate base pairs in DNA generating base substitutions. The most ...

    • Base excision repair of N4,5-dimethylcytosine in DNA 

      Arshad, Aysha (Masteroppgave/UIS-TN-IMN/2017;, Master thesis, 2017-07-13)
      5-Methylcytosine (m5C) replaces cytosine (C) in DNA in prokaryotic and eukaryotic cells to execute a number of important cellular functions, but damage to m5C have received little attention. For instance, almost no studies ...

    • The escherichia coli alkA gene is activated to alleviate mutagenesis by an oxidized deoxynucleoside 

      Grøsvik, Kristin; Tesfahun, Almaz Nigatu; Muruzábal-Lecumberri, Izaskun; Haugland, Gyri Teien; Leiros, Ingar; Ruoff, Peter; Kvaløy, Jan Terje; Knævelsrud, Ingeborg; Ånensen, Hilde; Alexeeva, Marina; Sato, Kousuke; Matsuda, Akira; Alseth, Ingrun; Klungland, Arne; Bjelland, Svein (Peer reviewed; Journal article, 2020)
      The cellular methyl donor S-adenosylmethionine (SAM) and other endo/exogenous agents methylate DNA bases non-enzymatically into products interfering with replication and transcription. An important product is 3-methyladenine ...

    • Excision of 5-hydroxymethyluracil in single-stranded DNA by hSMUG1 requires Ser26 and/or Glu35 and Pro240 

      Bærheim, Trond (Master thesis, 2021)
      The integrity of the genetic material of all organisms is assaulted continuously by a multitude of endogenous and exogenous agents throughout its lifetime, where the DNA bases of the genetic code may be altered if not ...

    • hUNG activity for uracil in bubble and R-loop DNA 

      Mehanna, Shimaa (Master thesis, 2021)
      Uracil, a common base in RNA, may arise in cellular DNA by cytosine deamination or during replication through the misincorporation of deoxyuridine monophosphate instead of thymidine monophosphate. Repair of uracil is ...

    • Intrinsic Strand-Incision Activity of Human UNG: Implications for Nick Generation in Immunoglobulin Gene Diversification 

      Alexeeva, Marina; Moen, Marivi Nabong; Xu, Xiang Ming; Rasmussen, Anette; Leiros, Ingar; Kirpekar, Finn; Klungland, Arne; Alsøe, Lene; Nilsen, Hilde; Bjelland, Svein (Peer reviewed; Journal article, 2021)
      Uracil arises in cellular DNA by cytosine (C) deamination and erroneous replicative incorporation of deoxyuridine monophosphate opposite adenine. The former generates C → thymine transition mutations if uracil is not removed ...

    • Molecular biology of modified DNA bases 

      Aanderaa, Inger Djuve (Masteroppgave/UIS-TN-IKBM/2019;, Master thesis, 2019-08)
      The cell has several mechanisms for repairing DNA damages, and it has been widely accepted that the base excision repair (BER) pathway is the main repair mechanism for small non helix distorting damages caused by oxidation. ...

    • Replacing Pro240 with Gly in hSMUG1 increases uracil excision in R-loop but abolish 5-hydroxymethyluracil excision in ssDNA 

      Lorentsen, Celine (Master thesis, 2021)
      Deamination and oxidation of pyrimidines are two major spontaneously damaging events in DNA. The DNA glycosylase SMUG1 initiates repair of deaminated or oxidized bases by breaking the glycosidic bond between the damaged ...

    • Uracil-excising activity of hSMUG1 in bubble and R-loop DNA 

      Ruales, Cyrell Ann (Master thesis, 2021)
      Uracil arises in cellular DNA by hydrolytic cytosine (C) deamination and by erroneous repli-cative incorporation of deoxyuridine monophosphate opposite adenine. The former event is devastating by generation of C  thymine ...