Browsing UiS Brage by Author "Haarr, Marianne Bore"
Now showing items 1-4 of 4
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1,4-Dideoxy-1,4-imino‑D‑arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α‑Mannosidase Inhibitors
Haarr, Marianne Bore; Lopez, Oscar; Pejov, Ljupcho; Fernandez-Bolanos, Jose G.; Lindback, Emil; Sydnes, Magne Olav (Peer reviewed; Journal article, 2020-07)The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-D-arabinitol (DAB) analogues bearing a hydrazide moiety is described. The DAB analogues act as selective and potent inhibitors of α-mannosidase ... -
Synthesis of an Alleged Byproduct Precursor in Iodixanol Preparation
Haarr, Marianne Bore; Lindback, Emil; Håland, Torfinn; Sydnes, Magne Olav (Peer reviewed; Journal article, 2018-07)N1,N3-Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(N-(oxiran-2-ylmethyl)acetamido)isophthalamide (1), the alleged precursor of several minor byproducts formed when the X-ray contrast agent iodixanol is synthesized from ... -
Synthesis of Biologically Active Iminosugars and Strategies Towards the Preparation of Chiral Quinoline Derivatives
Haarr, Marianne Bore (PhD thesis UiS;, Doctoral thesis, 2021-12)Design and preparation of novel bioactive compounds for development of new drug leads is a challenging task. Chirality plays a key role in all biological systems, including drug targets, and stereoisomeric compounds often ... -
Synthesis of the Hexahydropyrrolo‐[3,2‐c]‐quinoline Core Structure and Strategies for Further Elaboration to Martinelline, Martinellic Acid, Incargranine B, and Seneciobipyrrolidine
Haarr, Marianne Bore; Sydnes, Magne Olav (Peer reviewed; Journal article, 2021-01)Natural products are rich sources of interesting scaffolds possessing a plethora of biological activity. With the isolation of the martinella alkaloids in 1995, namely martinelline and martinellic acid, the pyrrolo[3,2‐c]quinoline ...