• Association of a BACE1 gene polymorphism with Parkinson’s disease in a Norwegian population 

      Lange, Johannes; Lunde, Kristin Aaser; Sletten, Camilla Johanne; Møller, Simon Geir; Tysnes, Ole-Bjørn; Alves, Guido; Larsen, Jan Petter; Maple-Grødem, Jodi (Journal article; Peer reviewed, 2015-11)
      Background . Parkinson’s disease (PD) and Alzheimer’s disease (AD) share pathological features, including amyloid-beta pathology. Amyloid-beta peptide is generated by sequential proteolysis of amyloid precursor protein ...
    • Combinatory microRNA serum signatures as classifiers of Parkinson's disease 

      Patil, Ketan S.; Basak, Indranil; Dalen, Ingvild; Hoedt, Esthelle; Lange, Johannes; Lunde, Kristin Aaser; Liu, Ying; Tysnes, Ole-Bjørn; Forsgren, Lars; Aarsland, Dag; Neubert, Thomas A.; Larsen, Jan Petter; Alves, Guido Werner; Møller, Simon Geir (Journal article; Peer reviewed, 2019-04)
      As current clinical diagnostic protocols for Parkinson's disease (PD) may be prone to inaccuracies there is a need to identify and validate molecular biomarkers, such as circulating microRNAs, which will complement current ...
    • Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease 

      Dölle, Christian; Flønes, Irene Hana; Sanchez Nido, Gonzalo; Miletic, Hrvoje; Osuagwu, Nelson; Kristoffersen, Stine; Lilleng, Peer Kåre; Larsen, Jan Petter; Tysnes, Ole-Bjørn; Haugarvoll, Kristoffer; Bindoff, Laurence; Tzoulis, Charalampos (Journal article; Peer reviewed, 2016-11)
      Increased somatic mitochondrial DNA (mtDNA) mutagenesis causes premature aging in mice, and mtDNA damage accumulates in the human brain with aging and neurodegenerative disorders such as Parkinson disease (PD). Here, we ...
    • Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease 

      Dölle, Christian; Flønes, Irene Hana; Sanchez Nido, Gonzalo; Miletic, Hrvoje; Osuagwu, Nelson; Kristoffersen, Stine; Lilleng, Peer Kåre; Larsen, Jan Petter; Tysnes, Ole-Bjørn; Haugarvoll, Kristoffer; Bindoff, Laurence; Tzoulis, Charalampos (Journal article; Peer reviewed, 2016-11)
      Increased somatic mitochondrial DNA (mtDNA) mutagenesis causes premature aging in mice, and mtDNA damage accumulates in the human brain with aging and neurodegenerative disorders such as Parkinson disease (PD). Here, we ...
    • Impact of exercise programs among helicopter pilots with transient LBP 

      Andersen, Knut; Baardsen, Roald; Dalen, Ingvild; Larsen, Jan Petter (Journal article; Peer reviewed, 2017-06)
      Background Flight related low back pain (LBP) among helicopter pilots is frequent and may influence flight performance. Prolonged confined sitting during flights seems to weaken lumbar trunk (LT) muscles with associated ...
    • The prevalence, implications, and clinical course of pregnancy-related pelvic girdle pain 

      Malmqvist, Stefan (PhD thesis UiS;, Doctoral thesis, 2021-12)
      Background Pelvic girdle pain (PGP) during pregnancy is common and, indeed, has always been considered normal. It is commonly associated with moderate to severe pain that impairs everyday activities such as getting up ...
    • The association between pelvic girdle pain and sick leave during pregnancy; a retrospective study of a Norwegian population 

      Malmqvist, Stefan; Andersen, Knut; Økland, Inger; Larsen, Jan Petter; Brønnick, Kolbjørn; Kjaerman, Inger (Journal article; Peer reviewed, 2015-10)
      Background: The incidence of pelvic girdle pain (PGP) in pregnancy is wide ranged depending on definition, the utilised diagnostic means, and the design of the studies. PGP during pregnancy has negative effects on activities ...
    • The GBA variant E326K is associated with Parkinson's disease and explains a genome-wide association signal 

      Berge-Seidl, Victoria; Pihlstrøm, Lasse; Maple-Grødem, Jodi; Forsgren, Lars; Linder, Jan; Larsen, Jan Petter; Tysnes, Ole-Bjørn; Toft, Harald Mathias Strøm (Journal article; Peer reviewed, 2017-09)
      Objective Coding variants in the GBA gene have been identified as the numerically most important genetic risk factors for Parkinson's disease (PD). In addition, genome-wide association studies (GWAS) have identified ...