Browsing UiS Brage by Author "Lindback, Emil"
Now showing items 1-7 of 7
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1,4-Dideoxy-1,4-imino‑D‑arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α‑Mannosidase Inhibitors
Haarr, Marianne Bore; Lopez, Oscar; Pejov, Ljupcho; Fernandez-Bolanos, Jose G.; Lindback, Emil; Sydnes, Magne Olav (Peer reviewed; Journal article, 2020-07)The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-D-arabinitol (DAB) analogues bearing a hydrazide moiety is described. The DAB analogues act as selective and potent inhibitors of α-mannosidase ... -
A complete synthesis of an N-spirofused iminosugar from L-xylose; a potential cholinesterase inhibitor for treatment of Alzheimer’s disease
Ersdal, Nikolai.; Sandvik, Mathias (Bachelor thesis, 2022)In this bachelor’s project we present a complete synthesis of an N-spirofused iminosugar II with a stable positive charge on the spirocyclic nitrogen atom that together with the hydroxyl groups are expected to establish ... -
Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase
Evangelista, Tereza Cristina Santos; Lopez, Oscar; Ferreira, Sabrina Baptista; Fernandez-Bolanos, Jose G.; Sydnes, Magne Olav; Lindback, Emil (Peer reviewed; Journal article, 2021-07)The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers of variable lengths is described. The multivalent inhibition potencies for the tacrine clusters ... -
A hybrid of 1-deoxynojirimycin and benzotriazole induces preferential inhibition of butyrylcholinesterase (BuChE) over acetylcholinesterase (AChE)
Evangelista, Tereza Cristina Santos; Lopez, Oscar; Puerta, Adrian; Fernandes, Miguel X.; Ferreira, Sabrina Baptista; Padron, Jose M.; Fernandez-Bolanos, Jose G.; Sydnes, Magne Olav; Lindback, Emil (Peer reviewed; Journal article, 2022)The synthesis of four heterodimers in which the copper(I)-catalysed azide-alkyne cycloaddition was employed to connect a 1-deoxynojirimycin moiety with a benzotriazole scaffold is reported. The heterodimers were investigated ... -
Investigation of the enantioselectivity of acetylcholinesterase and butyrylcholinesterase upon inhibition by tacrine-iminosugar heterodimers
Vaaland, Ingrid Caroline; Lopez, Oscar; Puerta, Adrian; Fernandes, Miguel X.; Padron, Jose M.; Fernandez-Bolanos, Jose G.; Sydnes, Magne Olav; Lindback, Emil (Peer reviewed; Journal article, 2023-09)The copper-catalysed azide-alkyne cycloaddition was applied to prepare three enantiomeric pairs of heterodimers containing a tacrine residue and a 1,4-dideoxy-1,4-imino-D-arabinitol (DAB) or 1,4-dideoxy-1,4-imino-L-arabinitol ... -
Synthesis and Evaluation of the Tetracyclic Ring-System of Isocryptolepine and Regioiso-Mers for Antimalarial, Antiproliferative and Antimicrobial Activities
Håheim, Katja Stangeland; Lindback, Emil; Tan, Kah Ni; Albrigtsen, Marte; Helgeland, Ida Therese Urdal; Clemence, Lauga; Matringe, Theodora; Kennedy, Emily K.; Andersen, Jeanette Hammer; Avery, Vicky M.; Sydnes, Magne Olav (Peer reviewed; Journal article, 2021-05)A series of novel quinoline-based tetracyclic ring-systems were synthesized and evaluated in vitro for their antiplasmodial, antiproliferative and antimicrobial activities. The novel hydroiodide salts 10 and 21 showed the ... -
Synthesis of an Alleged Byproduct Precursor in Iodixanol Preparation
Haarr, Marianne Bore; Lindback, Emil; Håland, Torfinn; Sydnes, Magne Olav (Peer reviewed; Journal article, 2018-07)N1,N3-Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(N-(oxiran-2-ylmethyl)acetamido)isophthalamide (1), the alleged precursor of several minor byproducts formed when the X-ray contrast agent iodixanol is synthesized from ...