Blar i UiS Brage på forfatter "Maple-Grødem, Jodi"
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Alpha-synuclein biomarkers of Parkinson's disease risk and heterogeneity
Pedersen, Camilla Christina (Masteroppgave/UIS-TN-IKBM/2020;, Master thesis, 2020-06)Parkinson’s disease (PD) is the second most common neurodegenerative disease and is the world’s fastest growing neurological disorder. PD is a motor disease, but many patients experience a range of non-motor features, ... -
Association of a BACE1 gene polymorphism with Parkinson’s disease in a Norwegian population
Lange, Johannes; Lunde, Kristin Aaser; Sletten, Camilla Johanne; Møller, Simon Geir; Tysnes, Ole-Bjørn; Alves, Guido; Larsen, Jan Petter; Maple-Grødem, Jodi (Journal article; Peer reviewed, 2015-11)Background . Parkinson’s disease (PD) and Alzheimer’s disease (AD) share pathological features, including amyloid-beta pathology. Amyloid-beta peptide is generated by sequential proteolysis of amyloid precursor protein ... -
Association of CSF Glucocerebrosidase Activity With the Risk of Incident Dementia in Patients With Parkinson Disease
Oftedal, Linn Silje Wathne; Maple-Grødem, Jodi; Dalen, Ingvild; Tysnes, Ole-Bjørn; Pedersen, Kenn Freddy; Alves, Guido Werner; Lange, Johannes (Peer reviewed; Journal article, 2022)Background and Objectives Variations in the glucocerebrosidase gene (GBA) are common risk factors for Parkinson disease (PD) and dementia in PD (PDD) and cause a reduction in the activity of the lysosomal enzyme ... -
Association of SNCA Parkinson's Disease Risk Polymorphisms With Disease Progression in Newly Diagnosed Patients
Szwedo, Aleksandra A; Pedersen, Camilla C; Ushakova, Anastasia; Forsgren, Lars; Tysnes, Ole-Bjørn; Counsell, Carl E.; Alves, Guido Werner; Lange, Johannes; Macleod, Angus D.; Maple-Grødem, Jodi (Peer reviewed; Journal article, 2021-02)Objectives: To evaluate the impact of SNCA polymorphisms originally identified as risk factors for Parkinson's disease (PD) on the clinical presentation and progression of the disease in a large cohort of population-based ... -
Cannabis use in Parkinson’s disease—A nationwide online survey study
Erga, Aleksander Hagen; Maple-Grødem, Jodi; Alves, Guido Werner (Peer reviewed; Journal article, 2022-02)Objectives The aim of this study was to investigate the frequency of use, attitudes toward, and experiences with cannabis and cannabis-related products among people with Parkinson's disease (PwP) living in Norway. Me ... -
Cognitive and Motor Decline in Dementia with Lewy Bodies and Parkinson's Disease Dementia
Gonzalez Velez, Maria Camila; Tovar-Rios, Diego Alejandro; Alves, Guido Werner; Dalen, Ingvild; Williams-Gray, Caroline H.; Camacho, Marta; Forsgren, Lars; Bäckström, David; Lawson, Rachael A.; Macleod, Angus D.; Counsell, Carl E.; Paquet, Claire; DeLena, Carlo; D'Antonio, Fabrizia; Pilotto, Andrea; Padovani, Alessandro; Blanc, Frédéric; Falup-Pecurariu, Cristian; Lewis, Simon J.G.; Rejdak, Konrad; Papuc, Ewa; Hort, Jakub; Nedelska, Zuzana; O'Brien, John; Bonanni, Laura; Marquié, Marta; Boada, Mercè; Pytel, Vanesa; Abdelnour, Carla; Alcolea, Daniel; Beyer, Katrin; Tysnes, Ole-Bjørn; Aarsland, Dag; Maple-Grødem, Jodi (Peer reviewed; Journal article, 2023)Background There is a need to better understand the rate of cognitive and motor decline of Dementia with Lewy bodies (DLB) and Parkinson's disease Dementia (PDD). Objectives To compare the rate of cognitive and motor ... -
Development of a constitutive and an auto-inducible high-yield expression system for recombinant protein production in the microalga Nannochloropsis oceanica
de Grahl, Imke; Rout, Sweta Suman; Maple-Grødem, Jodi; Reumann, Sigrun (Peer reviewed; Journal article, 2020-09)Photoautotrophic microalgae offer a great potential as novel hosts for efficient recombinant protein production. Nannochloropsis oceanica produces an extraordinarily high content of polyunsaturated fatty acids, and its ... -
Downregulation of N-terminal acetylation triggers ABA-mediated drought responses in Arabidopsis
Linster, Eric; Stephan, Iwona; Bienvenut, Willy V.; Maple-Grødem, Jodi; Myklebust, Line Merethe; Huber, Monika; Reichelt, Michael; Sticht, Carsten; Møller, Simon Geir; Meinnel, Thierry; Arnesen, Thomas; Giglione, Carmela; Hell, Rüdiger; Wirtz, Markus (Journal article; Peer reviewed, 2015-07)N-terminal acetylation (NTA) catalysed by N-terminal acetyltransferases (Nats) is among the most common protein modifications in eukaryotes, but its significance is still enigmatic. Here we characterize the plant NatA ... -
Excessive Daytime Sleepiness and REM Sleep Behavior Disorders in Parkinson's Disease: A Narrative Review on Early Intervention With Implications to Neuroprotection
Gjerstad, Michaela D; Alves, Guido Werner; Maple-Grødem, Jodi (Journal article; Peer reviewed, 2018-11)Sleep contributes to the consolidation of our memory and facilitates learning. Short term sleep deprivation temporarily reduces mnestic capacity, whereas long lasting sleep deprivation is associated with structural changes ... -
First delirium episode in Parkinson’s disease and parkinsonism: incidence, predictors, and outcomes
Green, Samantha; Perrott, Sarah L.; McCleary, Andrew; Sleeman, Isobel; Maple-Grødem, Jodi; Counsell, Carl E.; Macleod, Angus D. (Peer reviewed; Journal article, 2021-10)To define the incidence, predictors and prognosis of the first hospital delirium episode in Parkinson’s disease (PD) and atypical parkinsonism (AP), we identified the first hospital episode of delirium after diagnosis in ... -
GBA and APOE Impact Cognitive Decline in Parkinson's Disease: A 10-Year Population-Based Study
Szwedo, Aleksandra Anna; Dalen, Ingvild; Pedersen, Kenn Freddy; Camacho, Marta; Bäckström, David; Forsgren, Lars; Tzoulis, Charalampos; Winder-Rhodes, Sophie; Hudson, Gavin; Liu, Ganqiang; Scherzer, Clemens R.; Lawson, Rachael A.; Yarnall, Alison J.; Williams-Gray, Caroline H.; Macleod, Angus D.; Counsell, Carl E.; Tysnes, Ole-Bjørn; Alves, Guido Werner; Maple-Grødem, Jodi (Peer reviewed; Journal article, 2022)Background Common genetic variance in apolipoprotein E (APOE), β-glucocerebrosidase (GBA), microtubule-associated protein tau (MAPT), and α-synuclein (SNCA) has been linked to cognitive decline in Parkinson's disease (PD), ... -
Genetic risk of Parkinson disease and progression: An analysis of 13 longitudinal cohorts
Iwaki, Hirotaka; Blauwendraat, Cornelis; Leonard, Hampton L.; Liu, Ganqiang; Maple-Grødem, Jodi; Corvol, Jean-Christophe; Pihlstrøm, Lasse; van Nimwegen, Marlies; Hutten, Samantha J.; Nguyen, Khanh-Dung H.; Rick, Jacqueline; Eberly, Shirley; Faghri, Faraz; Auinger, Peggy; Scott, Kirsten M.; Wijeyekoon, Ruwani; van Deerlin, Vivianna M.; Hernandez, Dena G.; Day-Williams, Aaron G.; Brice, Alexis; Alves, Guido Werner; Noyce, Alastair J.; Tysnes, Ole-Bjørn; Evans, Jonathan R.; Breen, David P.; Estrada, Karol; Wegel, Claire E.; Danjou, Fabrice; Simon, David K.; Ravina, Bernard; Toft, Mathias; Heutink, Peter; Bloem, Bastiaan R.; Weintraub, Daniel; Barker, Roger A.; Williams-Gray, Caroline H.; van de Warrenburg, Bart P.; van Hilten, Jacobus J.; Scherzer, Clemens R.; Singleton, Andrew B.; Nalls, Mike A. (Journal article; Peer reviewed, 2019-08)Objective To determine if any association between previously identified alleles that confer risk for Parkinson disease and variables measuring disease progression. Methods We evaluated the association between 31 risk ... -
Genetic risk scores and hallucinations in patients with Parkinson disease
Kusters, Cynthia D.J.; Paul, Kimberly C.; Folle, Aline Duarte; Keener, Adrienne M.; Bronstein, Jeff M.; Dobricic, Valerija; Tysnes, Ole-Bjørn; Bertram, Lars; Alves, Guido Werner; Sinsheimer, Janet S.; Lill, Christina M.; Maple-Grødem, Jodi; Ritz, Beate R. (Peer reviewed; Journal article, 2020-07)Objective We examine the hypothesized overlap of genetic architecture for Alzheimer disease (AD), schizophrenia (SZ), and Parkinson disease (PD) through the use of polygenic risk scores (PRSs) with the occurrence of ... -
Identification of diagnostic and prognostic biomarkers of PD using a multiplex proteomics approach
Maple-Grødem, Jodi; Ushakova, Anastasia; Pedersen, Kenn Freddy; Tysnes, Ole-Bjørn; Alves, Guido Werner; Lange, Johannes (Peer reviewed; Journal article, 2023-10)Given the complexity of Parkinson's disease (PD), achieving acceptable diagnostic and prognostic accuracy will require the support of a panel of diverse biomarkers. We used Proximity extension assays to measure a panel of ... -
Identification of diagnostic and prognostic biomarkers of PD using a multiplex proteomics approach
Maple-Grødem, Jodi; Ushakova, Anastasia; Pedersen, Kenn Freddy; Tysnes, Ole-Bjørn; Alves, Guido Werner; Lange, Johannes (Peer reviewed; Journal article, 2023-09)Given the complexity of Parkinson's disease (PD), achieving acceptable diagnostic and prognostic accuracy will require the support of a panel of diverse biomarkers. We used Proximity extension assays to measure a panel of ... -
The incidence, baseline predictors, and outcomes of dementia in an incident cohort of Parkinson’s disease and controls
Counsell, Carl; Giuntoli, Cinzia; Khan, Qaisar Imran; Maple-Grødem, Jodi; Macleod, Angus D. (Peer reviewed; Journal article, 2022)Background There are few long-term data on the incidence, baseline predictors, and outcomes of dementia in Parkinson’s disease (PD) from prospective community-based incident cohorts. Methods The PINE study prospectively ... -
Molecular Characterization of the Plastid-localized ABC Protein TAP1 in Arabidopsis thaliana
Hempel, Jan Johansen (PhD thesis UiS;375, Doctoral thesis, 2018-01)The two TAP-like genes, AtTAP1 and AtTAP2, belong to the ABC transporter superfamily of Arabidopsis. AtTAP2/ALS1 has been shown to be important for aluminum metabolism and tolerance, however, little is known about the ... -
Parkinson’s disease clinical milestones and mortality
Gonzalez Velez, Maria Camila; Dalen, Ingvild; Maple-Grødem, Jodi; Tysnes, Ole-Bjørn; Alves, Guido Werner (Peer reviewed; Journal article, 2022)Identification of factors predicting and driving mortality in PD is important for patient information, disease management, and design of future clinical trials. This study included newly diagnosed PD patients and normal ... -
Plasma-derived exosome-like vesicles are enriched in lyso-phospholipids and pass the blood-brain barrier
Jakubec, Martin; Maple-Grødem, Jodi; Akbari, Saleha; Nesse, Susanne; Halskau, Øyvind; Mork-Jansson, Astrid Elisabeth (Peer reviewed; Journal article, 2020-09)Exosomes are vesicles involved in intercellular communication. Their membrane structure and core content is largely dependent on the cell of origin. Exosomes have been investigated both for their biological roles and their ... -
A systematic review of associations between common SNCA variants and clinical heterogeneity in Parkinson's disease
Pedersen, Camilla C; Lange, Johannes; Førland, Marthe Gurine; Macleod, Angus D.; Alves, Guido Werner; Maple-Grødem, Jodi (Peer reviewed; Journal article, 2021-07)There is great heterogeneity in both the clinical presentation and rate of disease progression among patients with Parkinson’s disease (PD). This can pose prognostic difficulties in a clinical setting, and a greater ...