Blar i UiS Brage på forfatter "Omdal, Roald"
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Anti-HMGB1 auto-Abs influence fatigue in patients with Crohn’s disease
Kvivik, Ingeborg; Grimstad, Tore Bjørn; Jonsson, Grete; Kvaløy, Jan T.; Omdal, Roald (Peer reviewed; Journal article, 2021-05)Fatigue is common in all chronic inflammatory and autoimmune diseases. A conceptual model for understanding the biological basis of fatigue describes it as being a part of the sickness behaviour response generated by ... -
Determination of lower cut-off levels of adalimumab associated with biochemical remission in Crohn's disease
Carlsen, Arne; Omdal, Roald; Karlsen, Lars Normann; Kvaløy, Jan Terje; Aabakken, Lars; Steinsbø, Øyvind; Bolstad, Nils; Warren, David; Lundin, Knut Erik Aslaksen; Grimstad, Tore (Journal article; Peer reviewed, 2019-08)Background and Aim: Adalimumab is administered and dosed using a standardized treatment regimen. Although therapeutic drug monitoring (TDM) may help optimize treatment efficacy, the lower cut-off concentration of adalimumab ... -
Fatigue in Parkinson's Disease: A Proteomic Study of Cerebrospinal Fluid
Eidem, Live Egeland; Birkeland, Even; Austdal, Marie; Bårdsen, Kjetil; Lange, Johannes; Alves, Guido Werner; Berven, Frode Steingrimsen; Nilsen, Mari Mæland; Herlofson, Karen; Tysnes, Ole-Bjørn; Omdal, Roald (Peer reviewed; Journal article, 2024-01)Many factors have been linked to fatigue in patients with Parkinson's disease (PD), including age, female sex, disease severity, depression, cognition, sleep disturbances, activities of daily living, and the use of dopamine ... -
Fatigue in primary Sjögren's syndrome: A proteomic pilot study of cerebrospinal fluid
Larssen, Eivind; Brede, Cato; Hjelle, Anne; Tjensvoll, Anne Bolette; Norheim, Katrine Brække; Bårdsen, Kjetil; Jonsdottir, Kristin; Ruoff, Peter; Omdal, Roald; Nilsen, Mari Mæland (Peer reviewed; Journal article, 2019-05)Objectives: Fatigue is a frequent and often disabling phenomenon that occurs in patients with chronic inflammatory and immunological diseases, and the underlying biological mechanisms are largely unknown. Because fatigue ... -
Fatigue: a frequent and biologically based phenomenon in newly diagnosed celiac disease
Skjellerudsveen, Berit Mære; Omdal, Roald; Hetta, Anne Kristine; Kvaløy, Jan Terje; Aabakken, Lars; Skoie, Inger Marie; Grimstad, Tore Bjørn (Peer reviewed; Journal article, 2022)Fatigue is increasingly recognized as a major complaint in patients with chronic inflammatory and autoimmune diseases. Although fatigue is assumed to represent a significant problem in celiac disease, existing knowledge ... -
Heat shock proteins and chronic fatigue in primary Sjögren's syndrome
Bårdsen, Kjetil; Mæland, Mari; Kvaløy, Jan Terje; Norheim, Katrine Brække; Jonsson, Grete; Omdal, Roald (Journal article; Peer reviewed, 2016-01)Fatigue occurs frequently in patients with cancer, neurological diseases and chronic inflammatory diseases, but the biological mechanisms that lead to and regulate fatigue are largely unknown. When ... -
Heat Shock Proteinα and Fatigue in Breast Cancer - A Cross Sectional Study
Andersen, Torill (Master thesis, 2021)Breast cancer is the most frequent malignancy among women and is often associated with fatigue during treatment. Fatigue may be considered as a sickness behavior syndrome, which is induced by activation of the innate immune ... -
Heat-shock protein 90α in plasma reflects severity of fatigue in patients with Crohn’s disease
Grimstad, Tore; Kvivik, Ingeborg; Kvaløy, Jan Terje; Aabakken, Lars; Omdal, Roald (Journal article; Peer reviewed, 2019-10)Heat-shock proteins (HSPs) are evolutionarily conserved proteins with important cellular homeostasis functions during harmful conditions, including inflammation. Some HSPs are secreted extracellularly and act on distant ... -
High mobility group box 1 and a network of other biomolecules influence fatigue in patients with Crohn’s disease
Kvivik, Ingeborg; Grimstad, Tore Bjørn; Bårdsen, Kjetil; Jonsson, Grete; Kvaløy, Jan Terje; Omdal, Roald (Peer reviewed; Journal article, 2023-06)Background Fatigue is common in patients with chronic inflammatory and autoimmune diseases, often with a severe impact on the patient’s daily life. From a biological point of view, fatigue can be regarded as an element ... -
Interleukin-1-related activity and hypocretin-1 in cerebrospinal fluid contribute to fatigue in primary Sjögren's syndrome
Bårdsen, Kjetil; Brede, Cato; Kvivik, Ingeborg; Kvaløy, Jan Terje; Jonsdottir, Kristin; Tjensvoll, Anne Bolette; Ruoff, Peter; Omdal, Roald (Peer reviewed; Journal article, 2019)Background Fatigue is a common and sometimes debilitating phenomenon in primary Sjögren’s syndrome (pSS) and other chronic inflammatory diseases. We aimed to investigate how IL-1 β-related molecules and the neuropeptide ... -
Less, but not gone—gluten-free diet effects on fatigue in celiac disease: a prospective controlled study
Skjellerudsveen, Berit Mære; Omdal, Roald; Hetta, Anne Kristine; Kvaløy, Jan Terje; Aabakken, Lars; Skoie, Inger Marie; Grimstad, Tore Bjørn (Peer reviewed; Journal article, 2023)Introduction: Fatigue is a frequent complaint in patients with celiac disease. A gluten-free diet is the only established treatment for celiac disease, but how this diet influences fatigue is uncertain. We aimed to investigate ... -
Nasal and salivary pepsin as a biomarker for gastro-esophageal reflux in chronic rhinosinusitis
Katle, Elin-Johanne; Hatlebakk, Jan Gunnar; Omdal, Roald; Kvaløy, Jan Terje; Steinsvåg, Sverre Karmhus (Journal article; Peer reviewed, 2019-03)Background: Gastro-esophageal reflux (GER) may be a contributing factor for some patients with chronic rhinosinusitis (CRS). The aim of the present study was to investigate if Peptest, an immunoassay for pepsin detection, ... -
Neurofilament light is a biomarker of brain involvement in lupus and primary Sjögren’s syndrome
Tjensvoll, Anne Bolette; Lauvsnes, Maria Boge; Zetterberg, Henrik; Kvaløy, Jan Terje; Kvivik, Ingeborg; Maroni, Stian; Greve, Ole Jacob; Beyer, Mona K.; Hirohata, Shunsei; Putterman, Chaim; Alves, Guido Werner; Harboe, Erna; Blennow, Kaj; Gøransson, Lasse; Omdal, Roald (Peer reviewed; Journal article, 2020-10)Background To test the hypothesis that neurofilament light (NfL) in CSF is a biomarker of CNS involvement in patients with systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS), we measured NfL in CSF ... -
No signs of mast cell involvement in long-COVID: A case–control study
Lenning, Ole Bernt; Jonsson, Grete; Grimstad, Tore Bjørn; Janssen, Emiel; Braut, Geir Sverre; Berven, Frode Steingrimsen; Omdal, Roald (Peer reviewed; Journal article, 2024-09)Long-COVID caused by SARS-CoV-2 infection has significant and increasing effects on human health worldwide. Although a unifying molecular or biological explanation is lacking, several pathophysiological mechanisms have ... -
Sample Preparation Strategies for Antibody-Free Quantitative Analysis of High Mobility Group Box 1 Protein
Kvivik, Ingeborg; Jonsson, Grete; Omdal, Roald; Brede, Cato (Peer reviewed; Journal article, 2021-06)Sickness behavior and fatigue are induced by cerebral mechanisms involving inflammatory cytokines. High mobility group box 1 (HMGB1) is an alarmin, and a potential key player in this process. Reliable quantification methods ... -
Thyroidectomy Versus Medical Management for Euthyroid Patients With Hashimoto Disease and Persisting Symptoms: A Randomized Trial
Guldvog, Ivar; Reitsma, Laurens Cornelus; Johnsen, Lene Cathrin; Lauzike, Andromeda; Gibbs, Charlotte Christine; Carlsen, Eivind; Lende, Tone Hoel; Narvestad, Jon; Omdal, Roald; Kvaløy, Jan Terje; Hoff, Geir; Bernklev, Tomm; Søiland, Håvard (Peer reviewed; Journal article, 2019-04)Background: Hashimoto disease is a chronic autoimmune thyroiditis. Despite adequate hormone substitution, some patients have persistent symptoms that may be the result of immunologic pathophysiology. Objective: To ...