Blar i UiS Brage på forfatter "Ruoff, Peter"
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Alexeeva, M., Moen, M.N., Grøsvik, K. et al (2018) Excision of uracil from DNA by hSMUG1 includes strand incision and processing.
Moen, Marivi Nabong; Grøsvik, Kristin; Kirpekar, Finn; Tesfahun, Almaz Nigatu; Ruoff, Peter; Klungland, Arne; Bjelland, Svein (Journal article; Peer reviewed, 2018-11)Uracil arises in DNA by hydrolytic deamination of cytosine (C) and by erroneous incorporation of deoxyuridine monophosphate opposite adenine, where the former event is devastating by generation of C → thymine transitions. ... -
Alleviation of C⋅C Mismatches in DNA by the Escherichia coli Fpg Protein
Tesfahun, Almaz Nigatu; Alexeeva, Marina; Tomkuvienė, Miglė; Arshad, Aysha; Guragain, Prashanna; Klungland, Arne; Klimašauskas, Saulius; Ruoff, Peter; Bjelland, Svein (Peer reviewed; Journal article, 2021-06)DNA polymerase III mis-insertion may, where not corrected by its 3′→ 5′ exonuclease or the mismatch repair (MMR) function, result in all possible non-cognate base pairs in DNA generating base substitutions. The most ... -
An amplified derepression controller with multisite inhibition and positive feedback
Drobac, Gorana; Waheed, Qaiser; Heidari, Behzad; Ruoff, Peter (Peer reviewed; Journal article, 2021-03)How organisms are able to maintain robust homeostasis has in recent years received increased attention by the use of combined control engineering and kinetic concepts, which led to the discovery of robust controller motifs. ... -
Antibacterial effect of chitosan in relation to active food packaging
Høie, Miriam (Masteroppgave/UIS-TN-IMN/2017;, Master thesis, 2017-06)Food safety has a high priority in the food industry. In order to be able to give the consumers safe products, the producers continuously work with methods to inhibit growth of bacteria in the foods during storage. Recently, ... -
Bioeconomic evaluation of extended season and year-round tomato production in Norway using supplemental light
Naseer, Muhammad; Persson, Tomas; Righini, Isabela; Stanghellini, Cecilia; Maessen, Hendricus; Ruoff, Peter; Verheul, Michel (Peer reviewed; Journal article, 2022)CONTEXT For high latitude countries like Norway, one of the biggest challenges associated with greenhouse production is the limited availability of natural light and heat, particularly in winters. This can be addressed ... -
Coherent feedback leads to robust background compensation in oscillatory and non-oscillatory homeostats
Nygård, Melissa; Ruoff, Peter (Peer reviewed; Journal article, 2023-08)When in a reaction kinetic integral controller a step perturbation is applied besides a constant background, the concentration of a controlled variable (described as A) will generally respond with decreased response ... -
Computational evaluation of different arrangements for the circadian clock in Arabidopsis thaliana.
Khan, Shanawar Ali (Masteroppgave/UIS-TN-IKBM/2019;, Master thesis, 2019-08)The circadian clock is an endogenous timekeeper that enables individuals to predict and adjust to their environment's regular differences between light and dark and high and low temperatures. This biological timing mechanism ... -
Detection and Characterization of Circulating Tumor Cells in Early Breast Cancer
Tidwell, Tia (Masteroppgave/UIS-TN-IMN/2016;, Master thesis, 2016-06)Background: Detection of circulating tumor cells (CTCs) has demonstrated prognostic significance in metastatic breast cancer. This is less studied in early breast cancer due to the rarity of such cells in early disease and ... -
Determination of porin channel activity and evolution of targeting signals in plant peroxisomes
Soni, Pradeep (University of Stavanger, Norway;, Doctoral thesis, 2013)Peroxisomes are eukaryotic organelles traditionally known for their roles in fatty acid metabolism and generation and removal of hydrogen peroxide. Several new functions are being ascribed to these organelles with the help ... -
DOPA Homeostasis by Dopamine: A Control-Theoretic View
Kleppe, Rune; Waheed, Qaiser; Ruoff, Peter (Peer reviewed; Journal article, 2021-11)Dopamine (DA) is an important signal mediator in the brain as well as in the periphery. The term “dopamine homeostasis” occasionally found in the literature refers to the fact that abnormal DA levels can be associated with ... -
Dopamine as a Homeostatic Regulator of Levodopa and its contribution to Neurological Disorders
Afradi, Olga (Bachelor thesis, 2021)Homeostasis is the tendency to maintain a relatively constant internal environment. The concept of homeostasis is essential when it comes to understanding organisms and their ability to adapt when faced with external ... -
Dopaminregulert DOPA homeostase og nevrodegenerative forstyrrelser
Bø, Lene Victoria (Bachelor thesis, 2021)Velfungerende mekanismer for homeostase leder til et robust homeostatisk dopaminerg system. Ett ikke-funksjonelt homeostatisk dopaminerg system er kjent for å være assosiert med nevrodegenerative lidelser som Parkinsons ... -
An economic and environmental analysis of greenhouse tomato production in Norway using a model-based technique
Naseer, Muhammad (PhD thesis UiS;, Doctoral thesis, 2022-12)The growing global population levels and the resulting increasing demands for food has put a lot of pressure on the food production systems and made the agricultural sector highly energy-intensive. The intensification in ... -
The effect of integral control in oscillatory and chaotic reaction kinetic networks
Thorsen, Kristian; Drengstig, Tormod; Ruoff, Peter (Peer reviewed; Journal article, 2019)Integral control is ubiquitously used in industrial processes to keep variables robustly regulated at a given setpoint. Integral control is also present in many biological systems where it, implemented through reaction ... -
The escherichia coli alkA gene is activated to alleviate mutagenesis by an oxidized deoxynucleoside
Grøsvik, Kristin; Tesfahun, Almaz Nigatu; Muruzábal-Lecumberri, Izaskun; Haugland, Gyri Teien; Leiros, Ingar; Ruoff, Peter; Kvaløy, Jan Terje; Knævelsrud, Ingeborg; Ånensen, Hilde; Alexeeva, Marina; Sato, Kousuke; Matsuda, Akira; Alseth, Ingrun; Klungland, Arne; Bjelland, Svein (Peer reviewed; Journal article, 2020)The cellular methyl donor S-adenosylmethionine (SAM) and other endo/exogenous agents methylate DNA bases non-enzymatically into products interfering with replication and transcription. An important product is 3-methyladenine ... -
Excision of 5-hydroxymethyluracil in single-stranded DNA by hSMUG1 requires Ser26 and/or Glu35 and Pro240
Bærheim, Trond (Master thesis, 2021)The integrity of the genetic material of all organisms is assaulted continuously by a multitude of endogenous and exogenous agents throughout its lifetime, where the DNA bases of the genetic code may be altered if not ... -
Fatigue in primary Sjögren's syndrome: A proteomic pilot study of cerebrospinal fluid
Larssen, Eivind; Brede, Cato; Hjelle, Anne; Tjensvoll, Anne Bolette; Norheim, Katrine Brække; Bårdsen, Kjetil; Jonsdottir, Kristin; Ruoff, Peter; Omdal, Roald; Nilsen, Mari Mæland (Peer reviewed; Journal article, 2019-05)Objectives: Fatigue is a frequent and often disabling phenomenon that occurs in patients with chronic inflammatory and immunological diseases, and the underlying biological mechanisms are largely unknown. Because fatigue ... -
Frequency switching between oscillatory homeostats and the regulation of p53
Ruoff, Peter; Nishiyama, Nobuaki (Peer reviewed; Journal article, 2020-05)Homeostasis is an essential concept to understand the stability of organisms and their adaptive behaviors when coping with external and internal assaults. Many hormones that take part in homeostatic control come in ... -
Homeostasis at different backgrounds: The roles of overlayed feedback structures in vertebrate photoadaptation
Grini, Jonas V.; Nygård, Melissa; Ruoff, Peter (Peer reviewed; Journal article, 2023)We have studied the resetting behavior of eight basic integral controller motifs with respect to different but constant backgrounds. We found that the controllers split symmetrically into two classes: one class, based on ... -
Homeostasis by depression kinetics with multisite inhibition and positive feedback
Drobac, Gorana (Masteroppgave/UIS-TN-IKBM/2020;, Master thesis, 2020)In order to survive all living organisms must, to some extent, be able to adapt to the changes in environment.In recent years there have been proposed different controller motifs that are used to explain how does the ...