Blar i UiS Brage på forfatter "Sydnes, Magne Olav"
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1,4-Dideoxy-1,4-imino‑D‑arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α‑Mannosidase Inhibitors
Haarr, Marianne Bore; Lopez, Oscar; Pejov, Ljupcho; Fernandez-Bolanos, Jose G.; Lindback, Emil; Sydnes, Magne Olav (Peer reviewed; Journal article, 2020-07)The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-D-arabinitol (DAB) analogues bearing a hydrazide moiety is described. The DAB analogues act as selective and potent inhibitors of α-mannosidase ... -
Bioaccumulation potential of the tricyclic antidepressant amitriptyline in a marine Polychaete, Nereis virens
Magnuson, Jason Tyler; Longenecker-Wright, Zoe; Havranek, Ivo; Monticelli, Giovanna; Brekken, Hans Kristian; Kallenborn, Roland; Schlenk, Daniel; Sydnes, Magne Olav; Pampanin, Daniela Maria (Peer reviewed; Journal article, 2022)The continual discharge of pharmaceuticals from wastewater treatment plants (WWTPs) into the marine environment, even at concentrations as low as ng/L, can exceed levels that induce sublethal effects to aquatic organisms. ... -
The burden of emerging contaminants upon an Atlantic Ocean marine protected reserve adjacent to Camps Bay, Cape Town, South Africa
Ojemaye, Cecilia Y.; Pampanin, Daniela Maria; Sydnes, Magne Olav; Green, Lesley; Petrik, Leslie (Peer reviewed; Journal article, 2022)The presence and levels of fifteen chemicals of emerging concerns, including five perfluorinated compounds (PFCs), two industrial chemicals, seven pharmaceuticals and one personal care product, were evaluated in biota, ... -
Changes in Plasma Pyruvate and TCA Cycle Metabolites upon Increased Hepatic Fatty Acid Oxidation and Ketogenesis in Male Wistar Rats
Dankel, Simon Nitter; Kalleklev, Tine-Lise; Tungland, siri Lunde; Stafsnes, Marit Hallvardsdotter; Bruheim, Per; Aloysius, Thomas Aquinas; Lindquist, Carine; SKORVE, JON; Nygård, Ottar Kjell; Madsen, Lise; Bjørndal, Bodil; Sydnes, Magne Olav; Berge, Rolf Kristian (Peer reviewed; Journal article, 2023)Altered hepatic mitochondrial fatty acid β-oxidation and associated tricarboxylic acid (TCA) cycle activity contributes to lifestyle-related diseases, and circulating biomarkers reflecting these changes could have disease ... -
Current wastewater treatment methods and emerging technologies with a focus on removal of pharmaceuticals.
Søyland, Andreas (Masteroppgave/UIS-TN-IKBM/2020;, Master thesis, 2020-06)The global consumption of pharmaceuticals is increasing, and in recent years there has been a growing concern surrounding the release of pharmaceuticals to the environment. Wastewater treatment plants (WWTP) have been ... -
Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase
Evangelista, Tereza Cristina Santos; Lopez, Oscar; Ferreira, Sabrina Baptista; Fernandez-Bolanos, Jose G.; Sydnes, Magne Olav; Lindback, Emil (Peer reviewed; Journal article, 2021-07)The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers of variable lengths is described. The multivalent inhibition potencies for the tacrine clusters ... -
Divergent Synthesis of Indolo[3,2- c]quinolines, Neocryptolepines and Related Tetracyclic Ring-Systems Containing Promising Biological Activities
Håheim, Katja S. (PhD thesis UiS;, Doctoral thesis, 2022)Malaria is a devastating tropical disease, claiming approximately 627 000 lives in 2020. Due to the appearance of resistance towards artemisinin-based therapies, the discovery of novel treatments are of paramount ... -
Enantioselective synthesis of (-)-(1R,2R)-1,2-dihydrochrysene-1,2-diol
Lorentzen, Marianne; Sydnes, Magne Olav; Jørgensen, Kåre Bredeli (Peer reviewed; Journal article, 2014)A general chiral building block containing the 1R,2R-trans-diol moiety was constructed utilizing the stereoselective Shi-epoxidation reaction on a tetralone scaffold assembled by a Negishi cross-coupling on N,N-diethylbenzamide. ... -
Evaluation of photodegradable chitin synthetase inhibitors for the treatment of salmon lice (Lepeophtheirus salmonis)
Sydnes, Magne Olav; Eikemo, Vebjørn; Espedal, Per Gunnar; Sydnes, Leiv K.; Nilsen, Frank (Peer reviewed; Journal article, 2023)Some photolabile ethanolamine analogues of the chitin synthetase inhibitors diflubenzuron, teflubenzuron, and lufenuron were tested for activity as anti-lice compounds towards salmon lice (Lepeophtheirus salmonis). Two ... -
Gastrointestinal microbial community changes in Atlantic cod (Gadus morhua) exposed to crude oil
Bagi, Andrea; Riiser, Even Sannes; Molland, Hilde Steine; Star, Bastiaan; Haverkamp, Thomas Hendricus Augustus; Sydnes, Magne Olav; Pampanin, Daniela Maria (Journal article; Peer reviewed, 2018-04)Background The expansion of offshore oil exploration increases the risk of marine species being exposed to oil pollution in currently pristine areas. The adverse effects of oil exposure through toxic properties of polycyclic ... -
A hybrid of 1-deoxynojirimycin and benzotriazole induces preferential inhibition of butyrylcholinesterase (BuChE) over acetylcholinesterase (AChE)
Evangelista, Tereza Cristina Santos; Lopez, Oscar; Puerta, Adrian; Fernandes, Miguel X.; Ferreira, Sabrina Baptista; Padron, Jose M.; Fernandez-Bolanos, Jose G.; Sydnes, Magne Olav; Lindback, Emil (Peer reviewed; Journal article, 2022)The synthesis of four heterodimers in which the copper(I)-catalysed azide-alkyne cycloaddition was employed to connect a 1-deoxynojirimycin moiety with a benzotriazole scaffold is reported. The heterodimers were investigated ... -
Investigation of the enantioselectivity of acetylcholinesterase and butyrylcholinesterase upon inhibition by tacrine-iminosugar heterodimers
Vaaland, Ingrid Caroline; Lopez, Oscar; Puerta, Adrian; Fernandes, Miguel X.; Padron, Jose M.; Fernandez-Bolanos, Jose G.; Sydnes, Magne Olav; Lindback, Emil (Peer reviewed; Journal article, 2023-09)The copper-catalysed azide-alkyne cycloaddition was applied to prepare three enantiomeric pairs of heterodimers containing a tacrine residue and a 1,4-dideoxy-1,4-imino-D-arabinitol (DAB) or 1,4-dideoxy-1,4-imino-L-arabinitol ... -
Kinase chemodiversity from the Arctic: the breitfussins
Østnes Hansen, Kine; Andersen, Jeanette hammer; Bayer, Annette; Pandey, Sunil Kumar; Lorentzen, Marianne; Jørgensen, Kåre Bredeli; Sydnes, Magne Olav; Guttormsen, Yngve; Baumann, Matthias; Koch, Uwe; Klebl, Bert; Eickhoff, Jan; Haug, Bengt Erik; Isaksson, Johan; Hansen, Espen (Journal article; Peer reviewed, 2019-10)In this work, we demonstrate that the indole-oxazole-pyrrole framework of the breitfussin family of natural products is a promising scaffold for kinase inhibition. Six new halogenated natural products, breitfussin C–H (3 ... -
Mapping the Antimicrobial Activity of Indoloquinoline and Neocryptolepine Analogues
Håheim, Katja Stangeland; Albrigtsen, Marte; Helland, Kirsti; Andersen, Jeanette Hammer; Sydnes, Magne Olav (Peer reviewed; Journal article, 2023) -
Naphthalene trans-dihydrodiols
Vaaland, Ingrid Caroline (Masteroppgave/UIS-TN-IKBM/2018;, Master thesis, 2018-09)The currently used GC-MS method for analysis of PAH metabolites in fish bile only focus on phenols; 1-naphthol, 2-naphthol, 1-hydroxyphenanthrene, and alkylated derivatives. 1- Hydroxypyrene is also included, but not ... -
Natural peptides with antioxidant activity from Atlantic cod and Atlantic salmon residual material
Pampanin, Daniela M.; Haar, Marianne Bore; Sydnes, Magne Olav (Journal article; Peer reviewed, 2016-03)Summary. Water-soluble peptides/proteins with molecular weight below 10 kDa were isolated from residual material of cod (liver, skin, and cod mix i.e. skin, frames, and viscera), and salmon (skin, and salmon mix i.e. skin, ... -
Photodegradable antimicrobial agents - synthesis, photodegradation, and biological evaluation
Eikemo, Vebjørn; Sydnes, Leiv K.; Sydnes, Magne Olav (Peer reviewed; Journal article, 2021-09)Multi-drug resistant (MDR) bacteria are already a significant health-care problem and are making the combat of infections quite challenging. Here we report the synthesis of several new compounds containing an ethanolamine ... -
Photodegradable Antimicrobial Agents: Synthesis and Mechanism of Degradation
Eikemo, Vebjørn; Holmelid, Bjarte; Sydnes, Leiv K.; Sydnes, Magne Olav (Peer reviewed; Journal article, 2022)As a strategy to inactivate antimicrobial agents after use, we designed a range of ethanolamine derivatives where four of them possessed interesting activity. The ethanolamine moiety facilitates photodecomposition, which ... -
Photodegradable Antimicrobial Agents: Towards Structure Optimization
Alves Souto de Aquino, Gabriel; Nguyen van Sang, Liza Maëva; Valery, Romane; Lanave, Maelys; Estopiñá-Durán, Susana; Håheim, Katja Stangeland; Baptista Ferreira, Sabrina; Sydnes, Magne Olav (Peer reviewed; Journal article, 2023)Antibiotic resistance continues to be an ominous threat facing human health globally and urgent action is required to limit the loss of human life. The pollution of antibiotics into the environment is one of the drivers ... -
Regiodivergent Synthesis and Biological Activities of Indoloquinoline Based Compounds
Håheim, Katja Stangeland; Sydnes, Magne Olav (Peer reviewed; Journal article, 2024)Cryptolepine, neocryptolepine, and isocryptolepine have remained popular synthetic targets ever since their isolation from the aqueous extracts of the West African climbing shrub Cryptolepis sanguinolenta. These natural ...