• Anaerobic Fungi: Past, Present, and Future 

      Hess, Matthias; Paul, Shyam S.; Puniya, Anil K.; van der Giezen, Mark; Shaw, Claire; Edwards, Joan E.; Fliegerova, Katerina (Peer reviewed; Journal article, 2020-10)
      Anaerobic fungi (AF) play an essential role in feed conversion due to their potent fiber degrading enzymes and invasive growth. Much has been learned about this unusual fungal phylum since the paradigm shifting work of ...
    • The Asgard Archaeal-Unique Contribution to Protein Families of the Eukaryotic Common Ancestor Was 0.3% 

      Knopp, Michael; Stockhorst, Simon; van der Giezen, Mark; Garg, Sriram G; Gould, Sven B (Peer reviewed; Journal article, 2021-04)
      The identification of the asgard archaea has fueled speculations regarding the nature of the archaeal host in eukaryogenesis and its level of complexity prior to endosymbiosis. Here, we analyzed the coding capacity of 150 ...
    • Bacterial investigation of the microbiome in the upper respiratory tract of healthy male sheep (Ovis aries) from Western Norway 

      Viste, Fredrik (Bachelor thesis, 2021)
      With sheep being one of the most important livestock in Norway the health and well-being of the animals is important. Working towards a better understanding of what bacterial finds one might expect in healthy sheep could ...
    • Entamoeba invadens; a study about the role of PLD1 and PLD2 in encystation 

      Kaneez, Fatima (Masteroppgave/UIS-TN-IKBM/2020;, Master thesis, 2020-12)
      One of the most common problem in the developing world is infectious diseases caused by poor living conditions and one such condition is called amoebiasis. The causative agent of which is Entamoeba histolytica; a ...
    • Evolutionary analysis of cellular reduction and anaerobicity in the hyper-prevalent gut microbe Blastocystis 

      Záhonová, Kristína; Low, Ross S.; Warren, Christopher J.; Cantoni, Diego; Herman, Emily K.; Yiangou, Lyto; Ribeiro, Cláudia A.; Phanprasert, Yasinee; Brown, Ian R.; Rueckert, Sonja; Baker, Nicola L.; Tachezy, Jan; Betts, Emma L.; Gentekaki, Eleni; van der Giezen, Mark; Clark, C. Graham; Jackson, Andrew P.; Dacks, Joel B.; Tsaousis, Anastasios D. (Peer reviewed; Journal article, 2023)
      Blastocystis is the most prevalent microbial eukaryote in the human and animal gut, yet its role as commensal or parasite is still under debate. Blastocystis has clearly undergone evolutionary adaptation to the gut environment ...
    • Further insight into the genetic diversity of Entamoeba coli and Entamoeba hartmanni 

      Stensvold, Christen Rune; Ascuña-Durand, Kasandra; Chihi, Amal; Belkessa, Salem; Kurt, Özgür; El-Badry, Ayman; van der Giezen, Mark; Clark, C. Graham (Peer reviewed; Journal article, 2022)
      Despite the species' wide distribution, studies of the genetic diversity within Entamoeba coli and Entamoeba hartmanni remain limited. In the present study, we provide further insight into the genetic diversity of both ...
    • Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri 

      Herman, Emily K.; Greninger, Alex; van der Giezen, Mark; Ginger, Michael L.; Ramirez-Macias, Inmaculada; Miller, Haylea C.; Morgan, Matthew J.; Tsaousis, Anastasios D.; Velle, Katrina; Vargova, Romana; Zahonova, Kristina; Najle, Sebastian Rodrigo; MacIntyre, Georgina; Muller, Norbert; Wittwer, Mattias; Zysset-Burri, Denise C.; Elias, Marek; Slamovits, Claudio H.; Weirauch, Matthew T.; Fritz-Laylin, Lilian; Marciano-Cabral, Francine; Puzon, Geoffrey J.; Walsh, Tom; Chiu, Charles; Dacks, Joel B. (Peer reviewed; Journal article, 2021)
      Background The opportunistic pathogen Naegleria fowleri establishes infection in the human brain, killing almost invariably within 2 weeks. The amoeba performs piece-meal ingestion, or trogocytosis, of brain material ...
    • Highly thermostable carboxylic acid reductases generated by ancestral sequence reconstruction 

      Thomas, Adam; Cutlan, Rhys; Finnigan, William; van der Giezen, Mark; Harmer, Nicholas (Peer reviewed; Journal article, 2019)
      Carboxylic acid reductases (CARs) are biocatalysts of industrial importance. Their properties, especially their poor stability, render them sub-optimal for use in a bioindustrial pipeline. Here, we employed ancestral ...
    • Inflammatorisk tarmsykdom og vurdering av tarmmikrobiota. 

      Vedvik, Victoria (Bachelor thesis, 2023)
      Inflammatorisk tarmsykdom (IBD) er en utbredt sykdom, spesielt i den vestlige verden. IBD klassifiseres normalt under to sykdommer; ulcerøs kolitt (UC) og Crohns sykdom (CD). Årsaken til IBD er ennå ikke kjent, men det er ...
    • Metagenomic analysis of 16S rRNA genes for bacteria in the course of treatment of IBD patients at SUS 

      Holtmon, Kristine Wighus (Bachelor thesis, 2022)
      Keywords: Oxford Nanopore sequencing, 16S rRNA gene sequencing, IBD Since IBD is an increasing disease globally, it is vital to find out more about it. IBD causes many symptoms for the patient, including somatic symptoms ...
    • Mycoplasma ovipneumoniae - a rare pathogen in Norwegian sheep or a missed diagnosis? 

      Haugland, Regine (Master thesis, 2021)
      The production and performance of an animal will be affected by an infection or disease that involves vital organs. Pneumonia is such a disease and is common to find in sheep, not only in Norway but in the whole world. ...
    • Network analysis of nitrate-sensitive oral microbiome reveals interactions with cognitive function and cardiovascular health across dietary interventions 

      Vanhatalo, Anni; L’Heureux, Johanna E.; Kelly, James; Blackwell, Jamie; Wylie, Lee; Fulford, Jonathan; Winyard, Paul; Williams, David; van der Giezen, Mark; Jones, Andrew (Peer reviewed; Journal article, 2021)
      Many oral bacteria reduce inorganic nitrate, a natural part of a vegetable-rich diet, into nitrite that acts as a precursor to nitric oxide, a regulator of vascular tone and neurotransmission. Aging is hallmarked by reduced ...
    • Rask diagnostikk for Salmonid alphavirus 2 og 3 i atlantisk laks. 

      Svendsen, Hanna Elisabeth (Bachelor thesis, 2022)
      Laks er en viktig eksportvare for Norge i tillegg til at den selges i store mengder innad i landet. Laksesykdommer som Infeksiøs lakseanemi (ILA) og Salmonid alphavirus (SAV), som fører til pankreassykdom (PD), fører til ...
    • Ricin B proteins from Saprolegnia parasitica translocate into fish cells 

      Juliussen, Helene Elise (Bachelor thesis, 2022)
      Saprolegnia parasitica is a pathogenic oomycete within the phylum of stramenopiles that mainly infects salmon and trout. It is found all over the world and causes a disease called saprolegniosis that often results in death ...
    • Stool Microbiota Diversity Analysis of Blastocystis-Positive and Blastocystis-Negative Individuals 

      Stensvold, Christen Rune; Sørland, Brede Aksdal; Berg, Rebecca P. K. D.; Andersen, Lee O’Brien; van der Giezen, Mark; Bowtell, Joanna L.; El-Badry, Ayman A.; Belkessa, Salem; Kurt, Özgür; Nielsen, Henrik Vedel (Peer reviewed; Journal article, 2022)
      Blastocystis is a unicellular eukaryote found in the gastrointestinal tract of both human and other animal hosts. The clinical significance of colonic Blastocystis colonization remains obscure. In this study, we used ...
    • The infectious diseases that pose a threat to the Norwegian farmed salmon industry in the coming years due to climate changes. 

      Tungland, Angelica Thorsen (Bachelor thesis, 2022)
      What emerging diseases can we expect as a threat to the rapidly growing and important farmed salmon industry in Norway due to anthropogenic environmental changes? This question will be answered as best as possible based ...
    • Third-generation sequencing of IBD patients’ gut microbiome 

      Tofthagen, Marthe (Master thesis, 2022)
      The current opportunities for thorough gut microbiota profiling using next-generation sequencing (NGS) have opened up for a wide range of metagenomic studies. IBD prevalence is increasing in developed and developing countries ...
    • Understanding the role of the shrimp gut microbiome in health and disease 

      Holt, Corey; Bass, David; Stentiford, Grant D.; van der Giezen, Mark (Peer reviewed; Journal article, 2020-04)
      With rapid increases in the global shrimp aquaculture sector, a focus on animal health during production becomes ever more important. Animal productivity is intimately linked to health, and the gut microbiome is becoming ...