Blar i PhD-avhandlinger (TN-IKBM) på emneord "VDP::Matematikk og Naturvitenskap: 400::Kjemi: 440"
Viser treff 1-10 av 10
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3D in vitro cancer models for drug screening: A study of glucose metabolism and drug response in 2D and 3D culture models
(PhD thesis UiS;, Doctoral thesis, 2022-03)Current drug screening protocols use in vitro cancer cell panels grown in 2D to evaluate drug response and select the most promising candidates for further in vivo testing. Most drug candidates fail at this stage, not ... -
Diastereoselectivity in Anomeric O-alkylation Glycosylation
(PhD thesis UiS;, Doctoral thesis, 2021-02)Biosynth AS used anomeric O-alkylation of α-haloacetophenones in their patented total synthesis of anthocyanins from 2006. There were, however, several challenges with stereoselectivity and yields when performing this ... -
Divergent Synthesis of Indolo[3,2- c]quinolines, Neocryptolepines and Related Tetracyclic Ring-Systems Containing Promising Biological Activities
(PhD thesis UiS;, Doctoral thesis, 2022)Malaria is a devastating tropical disease, claiming approximately 627 000 lives in 2020. Due to the appearance of resistance towards artemisinin-based therapies, the discovery of novel treatments are of paramount ... -
An economic and environmental analysis of greenhouse tomato production in Norway using a model-based technique
(PhD thesis UiS;, Doctoral thesis, 2022-12)The growing global population levels and the resulting increasing demands for food has put a lot of pressure on the food production systems and made the agricultural sector highly energy-intensive. The intensification in ... -
Investigation of Lactam- Based Kinetic Hydrate Inhibitors and the Synergetic Effect of Solvents
(PhD thesis UiS;, Doctoral thesis, 2022)Gas hydrate formation in flow lines is of notorious concern for the oil and gas industry, and it only gets bigger because of the never-ending pursuit of oil and gas compels the industry into deeper and colder waters. Gas ... -
Investigation of New Classes of Amide and Non-amide Kinetic Hydrate Inhibitors
(PhD thesis UiS;538, Doctoral thesis, 2020-09)The formation of gas hydrates can cause pipeline blockage during the transportation of gas and oil products, which is one of the main challenges for flow assurance in the petroleum industry. It is uneasy to remove gas ... -
Low-temperature anaerobic wastewater treatment by granulated biomass
(PhD thesis UiS;, Doctoral thesis, 2022-05)In this study, long-term operation of up-flow anaerobic sludge blanket (UASB) system treating real municipal wastewater at decreasing temperatures (25, 16, 12, 8.5, 5.5, and 2.5 °C) and variable organic loading rates from ... -
Metabolic Cancer Therapy Using Graphene Drug Carriers: A study of biguanide drug effects in cellular and zebrafish larvae model systems
(PhD thesis UiS;, Doctoral thesis, 2021-11)Targeting cancer metabolism is an increasingly important strategy in the fight against cancer relapse. Metabolic drugs belonging to the biguanides family have gained attention in cancer treatment due to their ability to ... -
Synthesis and Photodecomposition Studies of Photodegradable Antibiotics and Chitin Synthase Inhibitors
(PhD thesis UiS;, Doctoral thesis, 2022-05)The release of bioactive compounds to the biosphere, such as chitin synthase inhibitors that are causing negative effects in non-target organisms, or antibiotic agents that contribute to increasing antimicrobial resistance, ... -
Synthesis of Biologically Active Iminosugars and Strategies Towards the Preparation of Chiral Quinoline Derivatives
(PhD thesis UiS;, Doctoral thesis, 2021-12)Design and preparation of novel bioactive compounds for development of new drug leads is a challenging task. Chirality plays a key role in all biological systems, including drug targets, and stereoisomeric compounds often ...