Blar i Studentoppgaver (TN-IKBM) på forfatter "Lindbäck, Emil"
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A complete synthesis of an N-spirofused iminosugar from L-xylose; a potential cholinesterase inhibitor for treatment of Alzheimer’s disease
Ersdal, Nikolai; Sandvik, Mathias (Bachelor thesis, 2022)In this bachelor’s project we present a complete synthesis of an N-spirofused iminosugar II with a stable positive charge on the spirocyclic nitrogen atom that together with the hydroxyl groups are expected to establish ... -
Synthesis of tacrine- and coumarin-isocryptolepine hybrids as potential dual binding site acetylcholinesterase inhibitors
Bringsjord, Geir Magne Risbakken (Masteroppgave/UIS-TN-IKBM/2020;, Master thesis, 2020-08-10)This project presents the synthesis of tacrine and coumarin scaffolds armed with an alkyl-chain of varying length with an azido functionality and isocryptolepine scaffold armed with a terminal alkyne. The synthesis of ... -
Tacrine hybrids as multi-target-directed ligands against Alzheimer’s disease
Lende, Kristin (Masteroppgave/UIS-TN-IKBM/2020;, Master thesis, 2020-07)World health organization estimates that nearly 9.9 million people develop dementia each year. Alzheimer disease (AD) is the most common form of dementia, and contributes to 60-70% of the cases. In addition to affecting ...