Vis enkel innførsel

dc.contributor.authorKleiven, Øyunn
dc.contributor.authorOmland, Torbjørn
dc.contributor.authorSkadberg, Øyvind
dc.contributor.authorMelberg, Tor Harald
dc.contributor.authorBjørkavoll-Bergseth, Magnus
dc.contributor.authorAuestad, Bjørn Henrik
dc.contributor.authorBergseth, Rolf
dc.contributor.authorGreve, Ole Jacob
dc.contributor.authorAakre, Kristin Moberg
dc.contributor.authorØrn, Stein
dc.date.accessioned2020-01-08T11:47:35Z
dc.date.available2020-01-08T11:47:35Z
dc.date.created2019-08-02T12:39:17Z
dc.date.issued2019-06
dc.identifier.citationKleiven, Ø., Omland, T., Skadberg, Ø. et al. (2019) Occult obstructive coronary artery disease is associated with prolonged cardiac troponin elevation following strenuous exercise. European Journal of Preventive Cardiology, 1-10.nb_NO
dc.identifier.issn2047-4873
dc.identifier.urihttp://hdl.handle.net/11250/2635313
dc.description.abstractBackground Sudden cardiac death among middle-aged recreational athletes is predominantly due to myocardial ischaemia. This study examined whether measuring cardiac troponin I and T (cTnI and cTnT) after strenuous exercise could identify occult obstructive coronary artery disease. Design Prospective observational study. Methods Subjects were recruited from 1002 asymptomatic recreational cyclists completing a 91-km mountain bike race (North Sea Race Endurance Exercise Study). No subject had known cardiovascular disease or took cardiovascular medication. Blood samples were collected within 24 h before and 3 h and 24 h after the race. Coronary computed tomography angiography was performed in 80 participants with the highest post-exercise cTnI and in 40 reference subjects with moderately elevated cTnI values. Results Study subjects (N = 120) were 45 (36–52) years old and 74% were male. There were similar demographics in the High-cTnI group and the Reference group. The cTn concentrations were highest at 3 h post-race: cTnI, 224 (125–304) ng/L; cTnT, 89 (55–124) ng/L. Nine subjects had obstructive coronary artery disease on coronary computed tomography angiography, eight of whom were High-cTnI responders. Two subjects had myocardial bridging, both High-cTnI responders. Troponin concentrations at 24 h post-race were higher in subjects with obstructive coronary artery disease than in the rest of the cohort (n = 109): cTnI, 151 (72–233) ng/L vs. 24 (19–82) ng/L, p = 0.005; cTnT, 39 (25–55) ng/L vs. 20 (14–31) ng/L, p = 0.002. The areas under the receiver operating characteristic curves for predicting obstructive coronary artery disease were 0.79, p = 0.005 (cTnI) and 0.82, p = 0.002 (cTnT). Conclusion In subjects with occult obstructive coronary artery disease there was a prolonged elevation of cTn following strenuous exercise.nb_NO
dc.language.isoengnb_NO
dc.publisherSAGE Publishingnb_NO
dc.subjectkardiologinb_NO
dc.subjectsportnb_NO
dc.subjectidrettnb_NO
dc.subjectcoronary artery diseasenb_NO
dc.subjecthjertesykdommernb_NO
dc.subjecthjerteinfarktnb_NO
dc.titleOccult obstructive coronary artery disease is associated with prolonged cardiac troponin elevation following strenuous exercisenb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.rights.holder© The European Society of Cardiology 2019nb_NO
dc.subject.nsiVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771nb_NO
dc.source.pagenumber1-10nb_NO
dc.source.journalEuropean Journal of Preventive Cardiologynb_NO
dc.identifier.doi10.1177/2047487319852808
dc.identifier.cristin1713798
cristin.unitcode217,8,2,0
cristin.unitcode217,8,4,0
cristin.unitnameInstitutt for matematikk og fysikk
cristin.unitnameInstitutt for data- og elektroteknologi
cristin.ispublishedtrue
cristin.qualitycode2


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel