dc.contributor.author | Kleiven, Øyunn | |
dc.contributor.author | Omland, Torbjørn | |
dc.contributor.author | Skadberg, Øyvind | |
dc.contributor.author | Melberg, Tor Harald | |
dc.contributor.author | Bjørkavoll-Bergseth, Magnus | |
dc.contributor.author | Auestad, Bjørn Henrik | |
dc.contributor.author | Bergseth, Rolf | |
dc.contributor.author | Greve, Ole Jacob | |
dc.contributor.author | Aakre, Kristin Moberg | |
dc.contributor.author | Ørn, Stein | |
dc.date.accessioned | 2020-01-08T11:47:35Z | |
dc.date.available | 2020-01-08T11:47:35Z | |
dc.date.created | 2019-08-02T12:39:17Z | |
dc.date.issued | 2019-06 | |
dc.identifier.citation | Kleiven, Ø., Omland, T., Skadberg, Ø. et al. (2019) Occult obstructive coronary artery disease is associated with prolonged cardiac troponin elevation following strenuous exercise. European Journal of Preventive Cardiology, 1-10. | nb_NO |
dc.identifier.issn | 2047-4873 | |
dc.identifier.uri | http://hdl.handle.net/11250/2635313 | |
dc.description.abstract | Background
Sudden cardiac death among middle-aged recreational athletes is predominantly due to myocardial ischaemia. This study examined whether measuring cardiac troponin I and T (cTnI and cTnT) after strenuous exercise could identify occult obstructive coronary artery disease.
Design
Prospective observational study.
Methods
Subjects were recruited from 1002 asymptomatic recreational cyclists completing a 91-km mountain bike race (North Sea Race Endurance Exercise Study). No subject had known cardiovascular disease or took cardiovascular medication. Blood samples were collected within 24 h before and 3 h and 24 h after the race. Coronary computed tomography angiography was performed in 80 participants with the highest post-exercise cTnI and in 40 reference subjects with moderately elevated cTnI values.
Results
Study subjects (N = 120) were 45 (36–52) years old and 74% were male. There were similar demographics in the High-cTnI group and the Reference group. The cTn concentrations were highest at 3 h post-race: cTnI, 224 (125–304) ng/L; cTnT, 89 (55–124) ng/L. Nine subjects had obstructive coronary artery disease on coronary computed tomography angiography, eight of whom were High-cTnI responders. Two subjects had myocardial bridging, both High-cTnI responders. Troponin concentrations at 24 h post-race were higher in subjects with obstructive coronary artery disease than in the rest of the cohort (n = 109): cTnI, 151 (72–233) ng/L vs. 24 (19–82) ng/L, p = 0.005; cTnT, 39 (25–55) ng/L vs. 20 (14–31) ng/L, p = 0.002. The areas under the receiver operating characteristic curves for predicting obstructive coronary artery disease were 0.79, p = 0.005 (cTnI) and 0.82, p = 0.002 (cTnT).
Conclusion
In subjects with occult obstructive coronary artery disease there was a prolonged elevation of cTn following strenuous exercise. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | SAGE Publishing | nb_NO |
dc.subject | kardiologi | nb_NO |
dc.subject | sport | nb_NO |
dc.subject | idrett | nb_NO |
dc.subject | coronary artery disease | nb_NO |
dc.subject | hjertesykdommer | nb_NO |
dc.subject | hjerteinfarkt | nb_NO |
dc.title | Occult obstructive coronary artery disease is associated with prolonged cardiac troponin elevation following strenuous exercise | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | acceptedVersion | nb_NO |
dc.rights.holder | © The European Society of Cardiology 2019 | nb_NO |
dc.subject.nsi | VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 | nb_NO |
dc.source.pagenumber | 1-10 | nb_NO |
dc.source.journal | European Journal of Preventive Cardiology | nb_NO |
dc.identifier.doi | 10.1177/2047487319852808 | |
dc.identifier.cristin | 1713798 | |
cristin.unitcode | 217,8,2,0 | |
cristin.unitcode | 217,8,4,0 | |
cristin.unitname | Institutt for matematikk og fysikk | |
cristin.unitname | Institutt for data- og elektroteknologi | |
cristin.ispublished | true | |
cristin.qualitycode | 2 | |