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dc.contributor.authorSørensen, Karen Galta
dc.contributor.authorØymar, Knut
dc.contributor.authorDalen, Ingvild
dc.contributor.authorHalvorsen, Thomas
dc.contributor.authorMikalsen, Ingvild Bruun
dc.date.accessioned2020-01-31T14:45:29Z
dc.date.available2020-01-31T14:45:29Z
dc.date.created2020-01-30T12:37:41Z
dc.date.issued2019-10
dc.identifier.citationSørensen, K.G., Øymar, K., Dalen, I. et al. (2020) Pediatric Allergy and Immunology, 31(1), pp. 57-65.nb_NO
dc.identifier.issn0905-6157
dc.identifier.urihttp://hdl.handle.net/11250/2639131
dc.description.abstractBackground Various trajectories for lung function and bronchial hyper‐reactivity (BHR) from early childhood to adulthood are described, including puberty as a period with excessive lung growth. Bronchiolitis in infancy may be associated with increased risk of developing chronic obstructive pulmonary disease, but the development of respiratory patterns during puberty is poorly characterized for these children. We aimed to study the development and trajectories of lung function and BHR from 11 to 18 years of age in children hospitalized for bronchiolitis in infancy. Methods Infants hospitalized for bronchiolitis at the University Hospitals in Stavanger and Bergen, Norway, during 1997‐1998, and an age‐matched control group, were included in a longitudinal follow‐up study and examined at 11 and 18 years of age with spirometry and methacholine provocation test (MPT). The MPT data were managed as dose‐response slope (DRS) in the statistical analyses. Changes in lung function and DRS from 11 to 18 years of age were analyzed by generalized estimating equations, including interaction terms. Results z‐scores for forced vital capacity (FVC), forced expiratory volume in first second (FEV1), FEV1/FVC ratio, and DRS were not different from 11 to 18 years of age in both the post‐bronchiolitis and the control group. The trajectories from 11 to 18 years did not differ between the two groups. BHR at age 11 was independently associated with asthma at age 18. Conclusion Children hospitalized for bronchiolitis had stable predicted lung function and BHR from 11 to 18 years of age. The lung function trajectories were not different from controls.nb_NO
dc.language.isoengnb_NO
dc.publisherJohn Wiley & Sons Ltd.nb_NO
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.no*
dc.subjectlungefunksjonnb_NO
dc.subjectastmanb_NO
dc.subjectbarneastmanb_NO
dc.subjectbronkiolittnb_NO
dc.subjectluftveisinfeksjonnb_NO
dc.titleLung function and bronchial hyperreactivity from 11 to 18 years in children with bronchiolitis in infancy.nb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.rights.holder© 2019 The Authors.nb_NO
dc.subject.nsiVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Lung diseases: 777nb_NO
dc.source.pagenumber57-65nb_NO
dc.source.volume31nb_NO
dc.source.journalPediatric Allergy and Immunologynb_NO
dc.source.issue1nb_NO
dc.identifier.doi10.1111/pai.13137
dc.identifier.cristin1786291
cristin.unitcode217,13,2,0
cristin.unitnameAvdeling for kvalitet og helseteknologi
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
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