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dc.contributor.authorLarssen, Eivind
dc.contributor.authorBrede, Cato
dc.contributor.authorHjelle, Anne
dc.contributor.authorTjensvoll, Anne Bolette
dc.contributor.authorNorheim, Katrine Brække
dc.contributor.authorBårdsen, Kjetil
dc.contributor.authorJonsdottir, Kristin
dc.contributor.authorRuoff, Peter
dc.contributor.authorOmdal, Roald
dc.contributor.authorNilsen, Mari Mæland
dc.date.accessioned2020-06-24T13:15:15Z
dc.date.available2020-06-24T13:15:15Z
dc.date.created2019-12-12T10:48:06Z
dc.date.issued2019-05
dc.identifier.citationLarssen, E., Brede, C., Hjelle, A. et al. (2019) Fatigue in primary Sjögren's syndrome: A proteomic pilot study of cerebrospinal fluid. SAGE Open Medicine, 7, pp. 1-10.en_US
dc.identifier.issn2050-3121
dc.identifier.urihttps://hdl.handle.net/11250/2659353
dc.description.abstractObjectives: Fatigue is a frequent and often disabling phenomenon that occurs in patients with chronic inflammatory and immunological diseases, and the underlying biological mechanisms are largely unknown. Because fatigue is generated in the brain, we aimed to investigate cerebrospinal fluid and search for molecules that participate in the pathophysiology of fatigue processes. Methods: A label-free shotgun proteomics approach was applied to analyze the cerebrospinal fluid proteome of 20 patients with primary Sjögren’s syndrome. Fatigue was measured with the fatigue visual analog scale. Results: A total of 828 proteins were identified and the 15 top discriminatory proteins between patients with high and low fatigue were selected. Among these were apolipoprotein A4, hemopexin, pigment epithelium-derived factor, secretogranin-1, secretogranin-3, selenium-binding protein 1, and complement factor B. Conclusion: Most of the discriminatory proteins have important roles in regulation of innate immunity, cellular stress defense, and/or functions in the central nervous system. These proteins and their interacting protein networks may therefore have central roles in the generation and regulation of fatigue, and the findings contribute with evidence to the concept of fatigue as a biological phenomenon signaled through specific molecular pathways.en_US
dc.language.isoengen_US
dc.publisherSAGE Publishingen_US
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/deed.no*
dc.subjecthelsefagen_US
dc.subjectSjögrens syndromen_US
dc.subjectfatigueen_US
dc.titleFatigue in primary Sjögren's syndrome: A proteomic pilot study of cerebrospinal fluiden_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© The Author(s) 2019en_US
dc.subject.nsiVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750en_US
dc.source.pagenumber1-10en_US
dc.source.volume7en_US
dc.source.journalSAGE Open Medicineen_US
dc.identifier.doi10.1177/2050312119850390
dc.identifier.cristin1759845
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Navngivelse-Ikkekommersiell 4.0 Internasjonal
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