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dc.contributor.authorJoa, Inge
dc.contributor.authorBjørnestad, Jone Ravndal
dc.contributor.authorJohannessen, Jan Olav
dc.contributor.authorLangeveld, Johannes Hendrik
dc.contributor.authorStain, Helen J.
dc.contributor.authorWeibell, Melissa Anne Elin Authen
dc.contributor.authorHegelstad, Wenche
dc.identifier.citationJoa, I., Bjørnestad, J., Johannessen, J.O. et al. (2021) Early detection of ultra high risk for psychosis in a Norwegian catchment area: The two year follow-up of the Prevention of Psychosis study. Frontiers in Psychiatry, DOI: 10.3389/fpsyt.2021.573905en_US
dc.description.abstractObjectives: Most individuals experience a relatively long period of sub-clinical psychotic like symptoms, known as the ultra high risk (UHR) or at risk mental states (ARMS), prior to a first episode of psychosis. Approximately 95% of individuals who will later develop psychosis are not referred to specialized clinical services and assessed during the UHR phase. The study aimed to investigate whether a systematic early detection program, modeled after the successful early detection of psychosis program TIPS, would improve the detection of help-seeking UHR individuals. The secondary aim was to examine the rates and predictors of conversion to psychosis after 2 years. Method: The overall study design was a prospective (2012–2018), follow- up study of individuals fulfilling UHR inclusion criteria as assessed by the structural interview for prodromal syndromes (SIPS). Help-seeking UHR individuals were recruited through systematic early detection strategies in a Norwegian catchment area and treated in the public mental health services. Results: In the study period 141 UHR help-seeking individuals were identified. This averages an incidence of 7 per 100,000 people per year. The baseline assessment was completed by 99 of these and the 2 year psychosis conversion rate was 20%. A linear mixed-model regression analysis found that the significant predictors of conversion were the course of positive (0.038) and negative symptoms (0.017). Age was also a significant predictor and showed an interaction with female gender (<0.000). Conclusion: We managed to detect a proportion of UHR individuals in the upper range of the expected prediction by the population statistics and further case enrichment would improve this rate. Negative symptoms were significant predictors. As a risk factor for adverse functional outcomes and social marginalization, this could offer opportunities for earlier psychosocial intervention.en_US
dc.publisherFrontiers Media S.Aen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleEarly detection of ultra high risk for psychosis in a Norwegian catchment area: The two year follow-up of the Prevention of Psychosis studyen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.rights.holder© 2021 Joa, Bjornestad, Johannessen, Langeveld, Stain, Weibell and Hegelstad.en_US
dc.subject.nsiVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Psykiatri, barnepsykiatri: 757en_US
dc.source.journalFrontiers in Psychiatryen_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal