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dc.contributor.authorJaramillo-Jiménez, Alberto
dc.contributor.authorMelvær, Giil Lasse
dc.contributor.authorTovar-Rios, Diego Alejandro
dc.contributor.authorBorda, Miguel Germán
dc.contributor.authorFerreira, Daniel
dc.contributor.authorBrønnick, Kolbjørn Kallesten
dc.contributor.authorOppedal, Ketil
dc.contributor.authorAarsland, Dag
dc.date.accessioned2021-08-09T11:07:27Z
dc.date.available2021-08-09T11:07:27Z
dc.date.created2021-07-07T09:56:15Z
dc.date.issued2021-07
dc.identifier.citationJaramillo-Jimenez, A., Giil, L.M., Tovar-Rios, D.A. et al. (2021) Association Between Amygdala Volume and Trajectories of Neuropsychiatric Symptoms in Alzheimer’s Disease and Dementia With Lewy Bodies. Frontiers in Neurology, 12:679984..en_US
dc.identifier.issn1664-2295
dc.identifier.urihttps://hdl.handle.net/11250/2766990
dc.description.abstractIntroduction: The amygdala is implicated in psychiatric illness. Even as the amygdala undergoes significant atrophy in mild dementia, amygdala volume is underexplored as a risk factor for neuropsychiatric symptoms (NPS). Objective: To analyze the association between baseline amygdala volume and the longitudinal trajectories of NPS and cognitive decline in Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) over 5 years. Methods: Eighty-nine patients with mild dementia were included (AD = 55; DLB = 34). Amygdala volume was segmented from structural magnetic resonance images (sMRI) using a semi-automatic method (Freesurfer 6.0) and normalized by intracranial volumes. The intracranial volume-normalized amygdala was used as a predictor of the Neuropsychiatric Inventory (NPI) total score, ordinal NPI item scores (0 = absence of symptoms, 1–3 = mild symptoms, ≥4 = clinically relevant symptoms), and Mini-Mental State Examination (MMSE) as measured annually over 5 years using gamma, ordinal, and linear mixed-effects models, respectively. The models were adjusted for demographic variables, diagnosis, center of sMRI acquisition, and cognitive performance. Multiple testing-corrected p-values (q-values) are reported. Results: Larger intracranial volume-normalized amygdala was associated with less agitation/aggression (odds ratio (OR) = 0.62 [0.43, 0.90], p = 0.011, q = 0.038) and less MMSE decline per year (fixed effect = 0.70, [0.29, 1.03], p = 0.001, q = 0.010) but more depression (OR = 1.49 [1.09, 2.04], p = 0.013, q = 0.040). Conclusions: Greater amygdala volume in mild dementia is associated with lower odds of developing agitation/aggression, but higher odds of developing depression symptoms during the 5-year study period.en_US
dc.language.isoengen_US
dc.publisherFrontiers Media S.Aen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.subjectamygdalaen_US
dc.subjectAlzheimersen_US
dc.subjectdemensen_US
dc.subjectdemens med Lewy-legemeren_US
dc.titleAssociation Between Amygdala Volume and Trajectories of Neuropsychiatric Symptoms in Alzheimer’s Disease and Dementia With Lewy Bodiesen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© 2021 Jaramillo-Jimenez, Giil, Tovar-Rios, Borda, Ferreira, Brønnick, Oppedal and Aarsland.en_US
dc.subject.nsiVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Psykiatri, barnepsykiatri: 757en_US
dc.source.pagenumber13en_US
dc.source.volume12en_US
dc.source.journalFrontiers in Neurologyen_US
dc.identifier.doi10.3389/fneur.2021.679984
dc.identifier.cristin1920613
dc.source.articlenumber679984en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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