Blar i UiS Brage på forfatter "Janssen, Emiel"
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MiR-18a and miR-18b are expressed in the stroma of oestrogen receptor alpha negative breast cancers
Egeland, Nina Gran; Jonsdottir, Kristin; Aure, Miriam Ragle; Sahlberg, Kristine Kleivi; Kristensen, Vessela N.; Cronin-Fenton, Deirdre; Skaland, Ivar; Gudlaugsson, Einar; Baak, Jan P.A.; Janssen, Emiel (Peer reviewed; Journal article, 2020-05)Background Previously, we have shown that miR-18a and miR-18b gene expression strongly correlates with high proliferation, oestrogen receptor -negativity (ER−), cytokeratin 5/6 positivity and basal-like features of breast ... -
miRNA normalization enables joint analysis of several datasets to increase sensitivity and to reveal novel miRNAs differentially expressed in breast cancer
Ben-Elazar, Shay; Aure, Miriam Ragle; Jonsdottir, Kristin; Leivonen, Suvi-Katri; Kristensen, Vessela N.; Janssen, Emiel; Sahlberg, Kristine Kleivi; Lingjærde, Ole Christian; Yakhini, Zohar (Peer reviewed; Journal article, 2021-02)Different miRNA profiling protocols and technologies introduce differences in the resulting quantitative expression profiles. These include differences in the presence (and measurability) of certain miRNAs. We present and ... -
Mitotic activity index and CD25+ lymphocytes predict risk of stage progression in non-muscle invasive bladder cancer
Lillesand, Melinda; Kvikstad, Vebjørn; Mangrud, Målfrid Ok; Gudlaugsson, Einar; Van Diermen, Bianca; Skaland, Ivar; Baak, Johannes Peter A; Janssen, Emiel (Peer reviewed; Journal article, 2020-06)In urothelial cell type non-muscle invasive urinary bladder carcinoma, TNM stage and WHO grade are widely used to classify patients into low and high-risk groups for prognostic and therapeutic decision-making. However, ... -
A Multiscale Approach for Whole-Slide Image Segmentation of five Tissue Classes in Urothelial Carcinoma Slides
Wetteland, Rune; Engan, Kjersti; Eftestøl, Trygve Christian; Janssen, Emiel; Kvikstad, Vebjørn (Peer reviewed; Journal article, 2020)In pathology labs worldwide, we see an increasing number of tissue samples that need to be assessed without the same increase in the number of pathologists. Computational pathology, where digital scans of histological ... -
Pitfalls in machine learning-based assessment of tumor-infiltrating lymphocytes in breast cancer: a report of the international immuno-oncology biomarker working group
Thagaard, Jeppe; Broeckx, Glenn; Page, David B; Jahangir, Chowdhury Arif; Verbandt, Sara; Kos, Zuzana; Gupta, Rajarsi; Khiroya, Reena; Abduljabbar, Khalid; Acosta Haab, Gabriela; Acs, Balazs; Akturk, Guray; Almeida, Jonas S; Alvarado-Cabrero, Isabel; Amgad, Mohamed; Azmoudeh-Ardalan, Farid; Badve, Sunil; Baharun, Nurkhairul Bariyah; Balslev, Eva; Bellolio, Enrique R; Bheemaraju, Vydehi; Blenman, Kim RM; Botinelly Mendonça Fujimoto, Luciana; Bouchmaa, Najat; Burgues, Octavio; Chardas, Alexandros; Chon U Cheang, Maggie; Ciompi, Francesco; Cooper, Lee AD; Coosemans, An; Corredor, Germán; Dahl, Anders B; Dantas Portela, Flavio Luis; Deman, Frederik; Demaria, Sandra; Doré Hansen, Johan; Dudgeon, Sarah N; Ebstrup, Thomas; Elghazawy, Mahmoud; Fernandez-Martín, Claudio; Fox, Stephen B; Gallagher, William M; Giltnane, Jennifer M; Gnjatic, Sacha; Gonzalez-Ericsson, Paula I; Grigoriadis, Anita; Halama, Niels; Hanna, Matthew G; Harbhajanka, Aparna; Hart, Steven N; Hartman, Johan; Hauberg, Søren; Hewitt, Stephen; Hida, Akira I; Horlings, Hugo M; Husain, Zaheed; Hytopoulos, Evangelos; Irshad, Sheeba; Janssen, Emiel; Kahila, Mohamed; Kataoka, Tatsuki R; Kawaguchi, Kosuke; Kharidehal, Durga; Khramtsov, Andrey I; Kiraz, Umay; Kirtani, Pawan; Kodach, Liudmila L; Korski, Konstanty; Kovács, Anikó; Laenkholm, Anne-Vibeke; Lang-Schwarz, Corinna; Larsimont, Denis; Lennerz, Jochen K; Lerousseau, Marvin; Li, Xiaoxian; Ly, Amy; Madabhushi, Anant; Maley, Sai K; Manur Narasimhamurthy, Vidya; Marks, Douglas K; McDonald, Elizabeth S; Mehrotra, Ravi; Michiels, Stefan; Minhas, Fayyaz ul Amir Afsar; Mittal, Shachi; Moore, David A; Mushtaq, Shamim; Nighat, Hussain; Papathomas, Thomas; Penault-Llorca, Frederique; Perera, Rashindrie D; Pinard, Christopher J; Pinto-Cardenas, Juan Carlos; Pruneri, Giancarlo; Pusztai, Lajos; Rahman, Arman; Rajpoot, Nasir Mahmood; Rapoport, Bernardo Leon; Rau, Tilman T; Reis-Filho, Jorge S; Ribeiro, Joana M; Rimm, David; Roslind, Anne; Vincent-Salomon, Anne; Salto-Tellez, Manuel; Saltz, Joel; Sayed, Shahin; Scott, Ely; Siziopikou, Kalliopi P; Sotiriou, Christos; Stenzinger, Albrecht; Sughayer, Maher A; Sur, Daniel; Fineberg, Susan; Symmans, Fraser; Tanaka, Sunao; Taxter, Timothy; Tejpar, Sabine; Teuwen, Jonas; Thompson, E Aubrey; Tramm, Trine; Tran, William T; van der Laak, Jeroen; van Diest, Paul J; Verghese, Gregory E; Viale, Giuseppe; Vieth, Michael; Wahab, Noorul; Walter, Thomas; Waumans, Yannick; Wen, Hannah Y; Yang, Wentao; Yuan, Yinyin; Zin, Reena Md; Adams, Sylvia; Bartlett, John; Loibl, Sibylle; Denkert, Carsten; Savas, Peter; Loi, Sherene; Salgado, Roberto; Specht Stovgaard, Elisabeth (Peer reviewed; Journal article, 2023)The clinical significance of the tumor-immune interaction in breast cancer is now established, and tumor-infiltrating lymphocytes (TILs) have emerged as predictive and prognostic biomarkers for patients with triple-negative ... -
Prenatal BRCA1 epimutations contribute significantly to triple-negative breast cancer development
Nikolaienko, Oleksii; Eikesdal, Hans Petter; Berge, Elisabet Ognedal; Gilje, Bjørnar; Lundgren, Steinar; Blix, Egil Støre; Espelid, Helge; Geisler, Jürgen; Geisler, Stephanie; Janssen, Emiel; Yndestad, Synnøve; Minsaas, Laura; Leirvaag, Beryl; Lillestøl, Reidun Kristine; Knappskog, Stian; Lønning, Per Eystein (Peer reviewed; Journal article, 2023)Background Normal cell BRCA1 epimutations have been associated with increased risk of triple-negative breast cancer (TNBC). However, the fraction of TNBCs that may have BRCA1 epimutations as their underlying cause is ... -
Prognostic value and reproducibility of different microscopic characteristics in the WHO grading systems for pTa and pT1 urinary bladder urothelial carcinomas
Kvikstad, Vebjørn; Mangrud, Målfrid Ok; Gudlaugsson, Einar; Dalen, Ingvild; Espeland, Hans; Baak, Jan P.A.; Janssen, Emiel (Peer reviewed; Journal article, 2019-08)Background: European treatment guidelines for pTa and pT1 urinary bladder urothelial carcinoma depend highly on stage and WHO-grade. Both the WHO73 and the WHO04 grading systems show some intra- and interobserver variability. ... -
Relation between prognostic factors and MicroRNAs (miR-18a/miR-18b) in triple negative breast cancer
Raghe, Sadia Hassan (Master thesis, 2022)Breast cancer is the most common type of malignancy found in women. It is a very heterogenous disease and treatments vary accordingly. Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer ... -
Semi-supervised tissue segmentation of histological images
Wetteland, Rune; Dalheim, Ove Nicolai; Kvikstad, Vebjørn; Janssen, Emiel; Engan, Kjersti (Peer reviewed; Journal article, 2020-09)Supervised learning of convolutional neural networks (CNN) used for image classification and segmentation has produced state-of-the art results, including in many medical image applications. In the medical field, making ... -
Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients
Helland, Thomas; Henne, Nina; Bifulco, Ersilia; Naume, Bjørn; Borgen, Elin; Kristensen, Vessela N.; Kvaløy, Jan Terje; Lash, Timothy L; Grenaker, Grethe Irene; van Schaik, RHN; Janssen, Emiel; Hustad, Steinar; Lien, Ernst Asbjørn; Mellgren, Gunnar; Søiland, Håvard (Journal article; Peer reviewed, 2017)Background Controversies exist as to whether the genetic polymorphisms of the enzymes responsible for the metabolism of tamoxifen can predict breast cancer outcome in patients using adjuvant tamoxifen. Direct measurement ... -
Spatial analyses of immune cell infiltration in cancer: current methods and future directions. A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer
Page, David B; Broeckx, Glenn; Jahangir, Chowdhury Arif; Verbandt, Sara; Gupta, Rajarsi R; Thagaard, Jeppe; Khiroya, Reena; Kos, Zuzana; Abduljabbar, Khalid; Acosta Haab, Gabriela; Acs, Balazs; Akturk, Guray; Almeida, Jonas S; Alvarado-Cabrero, Isabel; Azmoudeh-Ardalan, Farid; Badve, Sunil; Baharun, Nurkhairul Bariyah; Bellolio, Enrique R; Bheemaraju, Vydehi; Blenman, Kim RM; Botinelly Mendonça Fujimoto, Luciana; Bouchmaa, Najat; Burgues, Octavio; Cheang, Maggie Chon U; Ciompi, Francesco; Cooper, Lee AD; Coosemans, An; Corredor, Germán; Dantas Portela, Flavio Luis; Deman, Frederik; Demaria, Sandra; Dudgeon, Sarah N; Elghazawy, Mahmoud; Ely, Scott; Fernandez-Martín, Claudio; Fineberg, Susan; Fox, Stephen B; Gallagher, William M; Giltnane, Jennifer M; Gnjatic, Sacha; Gonzalez-Ericsson, Paula I; Grigoriadis, Anita; Halama, Niels; Hanna, Matthew G; Harbhajanka, Aparna; Hardas, Alexandros; Hart, Steven N; Hartman, Johan; Hewitt, Stephen; Hida, Akira I; Horlings, Hugo M; Husain, Zaheed; Hytopoulos, Evangelos; Irshad, Sheeba; Janssen, Emiel; Kahila, Mohamed; Kataoka, Tatsuki R; Kawaguchi, Kosuke; Kharidehal, Durga; Khramtsov, Andrey I; Kiraz, Umay; Kirtani, Pawan; Kodach, Liudmila L; Korski, Konstanty; Kovács, Anikó; Laenkholm, Anne-Vibeke; Lang-Schwarz, Corinna; Larsimont, Denis; Lennerz, Jochen K; Lerousseau, Marvin; Li, Xiaoxian; Ly, Amy; Madabhushi, Anant; Maley, Sai K; Manur Narasimhamurthy, Vidya; Marks, Douglas K; McDonald, Elizabeth S; Mehrotra, Ravi; Michiels, Stefan; Minhas, Fayyaz ul Amir Afsar; Mittal, Shachi; Moore, David A; Mushtaq, Shamim; Nighat, Hussain; Papathomas, Thomas; Penault-Llorca, Frederique; Perera, Rashindrie D; Pinard, Christopher J; Pinto-Cardenas, Juan Carlos; Pruneri, Giancarlo; Pusztai, Lajos; Rahman, Arman; Rajpoot, Nasir Mahmood; Rapoport, Bernardo Leon; Rau, Tilman T; Reis-Filho, Jorge S; Ribeiro, Joana M; Rimm, David; Vincent-Salomon, Anne; Salto-Tellez, Manuel; Saltz, Joel; Sayed, Shahin; Siziopikou, Kalliopi P; Sotiriou, Christos; Stenzinger, Albrecht; Sughayer, Maher A; Sur, Daniel; Symmans, Fraser; Tanaka, Sunao; Taxter, Timothy; Tejpar, Sabine; Teuwen, Jonas; Thompson, E Aubrey; Tramm, Trine; Tran, William T; van der Laak, Jeroen; van Diest, Paul J; Verghese, Gregory E; Viale, Giuseppe; Vieth, Michael; Wahab, Noorul; Walter, Thomas; Waumans, Yannick; Wen, Hannah Y; Yang, Wentao; Yuan, Yinyin; Adams, Sylvia; Bartlett, John Mark Seaverns; Loibl, Sibylle; Denkert, Carsten; Savas, Peter; Loi, Sherene; Salgado, Roberto; Specht Stovgaard, Elisabeth (Peer reviewed; Journal article, 2023)Modern histologic imaging platforms coupled with machine learning methods have provided new opportunities to map the spatial distribution of immune cells in the tumor microenvironment. However, there exists no standardized ... -
Triaging HPV-Positive Cervical Samples with p16 and Ki-67 Dual Stained Cytology within an Organized Screening Program—A Prospective Observational Study from Western Norway
Øvestad, Irene Tveiterås; Dalen, Ingvild; Andersland, Marie Songstad; Vintermyr, Olav Karsten; Moltu, Pia; Berland, Jannicke; Janssen, Emiel; Haugland, Hans Kristian (Peer reviewed; Journal article, 2023)The implementation of high-risk human papillomavirus testing (hrHPV testing) as a screening method in substitute for cytology has evoked the need for more sensitive and less objective tests for the triage of HPV-positive ... -
Unveiling the potential of alterations in urine microbiome, microRNA expression and DNA alterations as noninvasive biomarkers for bladder cancer: a multi-omics study using an innovative filtration method
Lassa, Elisabeth (Master thesis, 2023)Bladder cancer (BC) carries a large societal burden, in 2018 it was the 10th most common malignancy worldwide with 550,000 new cases and an estimated death rate of 200,000 (1). Patients diagnosed with low-grade tumors are ... -
A U‑net based approach to epidermal tissue segmentation in whole slide histopathological images
Oskal, Kay Raymond; Risdal, Martin; Janssen, Emiel; Undersrud, Erling Sandøy; Gulsrud, Thor Ole (Peer reviewed; Journal article, 2019-06)Malignant melanoma is a severe and aggressive type of skin cancer, with a rapid decrease in survival rate if not diagnosed and treated at an early stage. Histopathological examination of hematoxylin and eosin stained tissue ... -
Validation study of MARCKSL1 as a prognostic factor in lymph node-negative breast cancer patients
Egeland, Nina Gran; Austdal, Marie; Van Diermen, Bianca; Rewcastle, Emma; Gudlaugsson, Einar; Baak, Jan P.A.; Skaland, Ivar; Janssen, Emiel; Jonsdottir, Kristin (Peer reviewed; Journal article, 2019)Protein expression of Myristoylated alanine-rich C kinase substrate like-1 (MARCKSL1) has been identified as a prognostic factor in lymph-node negative (LN-) breast cancer patients. We aim to validate MARCKSL1 protein ...