Blar i UiS Brage på forfatter "Sydnes, Magne Olav"
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Regiodivergent Synthesis of 11H-Indolo[3,2-c]quinolines and Neocryptolepine from a Common Starting Material
Håheim, Katja Stangeland; Lund, Bjarte Aarmo; Sydnes, Magne Olav (Peer reviewed; Journal article, 2023)A large number of diversely functionalized analogs of the bioactive natural products neocryptolepine and isocryptolepine have been prepared from a series of 3-bromoquinoline derivatives. The neocryptolepines were obtained ... -
Study of the long-finned pilot whale (Globicephala melas) bile content - An indicator of ocean health
Pampanin, Daniela Maria; Arnli, William Bossum; Magnuson, Jason Tyler; Monticelli, Giovanna; Dam, Maria; Mikalsen, Svein-Ole; Sydnes, Magne Olav (Peer reviewed; Journal article, 2023)Globicephala melas has been harvested in the Faroe Islands for centuries. Given the distances travelled by this species, tissue/body fluid samples represent unique matrices to be considered as an integration of environmental ... -
Substituted Two- To Five-Ring Polycyclic Aromatic Compounds Are Potent Agonists of Atlantic Cod (Gadus morhua) Aryl Hydrocarbon Receptors Ahr1a and Ahr2a
Lille-Langøy, Roger; Jørgensen, Kåre Bredeli; Goksøyr, Anders; Pampanin, Daniela Maria; Sydnes, Magne Olav; Karlsen, Odd André (Peer reviewed; Journal article, 2021)Polycyclic aromatic hydrocarbons (PAHs) are among the most toxic and bioavailable components found in petroleum and represent a high risk to aquatic organisms. The aryl hydrocarbon receptor (Ahr) is a ligand-activated ... -
Synthesis and Evaluation of the Tetracyclic Ring-System of Isocryptolepine and Regioiso-Mers for Antimalarial, Antiproliferative and Antimicrobial Activities
Håheim, Katja Stangeland; Lindback, Emil; Tan, Kah Ni; Albrigtsen, Marte; Helgeland, Ida Therese Urdal; Clemence, Lauga; Matringe, Theodora; Kennedy, Emily K.; Andersen, Jeanette Hammer; Avery, Vicky M.; Sydnes, Magne Olav (Peer reviewed; Journal article, 2021-05)A series of novel quinoline-based tetracyclic ring-systems were synthesized and evaluated in vitro for their antiplasmodial, antiproliferative and antimicrobial activities. The novel hydroiodide salts 10 and 21 showed the ... -
Synthesis and Photodecomposition Studies of Photodegradable Antibiotics and Chitin Synthase Inhibitors
Eikemo, Vebjørn (PhD thesis UiS;, Doctoral thesis, 2022-05)The release of bioactive compounds to the biosphere, such as chitin synthase inhibitors that are causing negative effects in non-target organisms, or antibiotic agents that contribute to increasing antimicrobial resistance, ... -
Synthesis of an Alleged Byproduct Precursor in Iodixanol Preparation
Haarr, Marianne Bore; Lindback, Emil; Håland, Torfinn; Sydnes, Magne Olav (Peer reviewed; Journal article, 2018-07)N1,N3-Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(N-(oxiran-2-ylmethyl)acetamido)isophthalamide (1), the alleged precursor of several minor byproducts formed when the X-ray contrast agent iodixanol is synthesized from ... -
Synthesis of Biologically Active Iminosugars and Strategies Towards the Preparation of Chiral Quinoline Derivatives
Haarr, Marianne Bore (PhD thesis UiS;, Doctoral thesis, 2021-12)Design and preparation of novel bioactive compounds for development of new drug leads is a challenging task. Chirality plays a key role in all biological systems, including drug targets, and stereoisomeric compounds often ... -
Synthesis of isocryptolepine and analogues for antimalarial evaluation
Håheim, Katja Stangeland (Masteroppgave/UIS-TN-IKBM/2018;, Master thesis, 2018-07)Malaria is considered a serious global health concern, causing 445 000 deaths annually. With the increasing apperance of drug resistant cases of Plasmodium strains, discovery of new treatments are of paramount importance. ... -
Synthesis of Quinone Metabolites by Electrochemical and Chemical Oxidation
Tiruye, Hiwot Minwuyelet (PhD thesis UiS;, Doctoral thesis, 2024)Electrochemical oxidation of polycyclic aromatic phenols (PAPs) has been developed in a microfluidic flow cell to synthesize polycyclic aromatic quinones. This method applies methanol as a nucleophile source while OH directs ... -
Synthesis of the Hexahydropyrrolo‐[3,2‐c]‐quinoline Core Structure and Strategies for Further Elaboration to Martinelline, Martinellic Acid, Incargranine B, and Seneciobipyrrolidine
Haarr, Marianne Bore; Sydnes, Magne Olav (Peer reviewed; Journal article, 2021-01)Natural products are rich sources of interesting scaffolds possessing a plethora of biological activity. With the isolation of the martinella alkaloids in 1995, namely martinelline and martinellic acid, the pyrrolo[3,2‐c]quinoline ... -
Synthesis of trans-dihydronaphthalene-diol and evaluation of their use as standards for PAH metabolite analysis in fish bile by GC-MS
Vaaland, Ingrid Caroline; Pampanin, Daniela Maria; Sydnes, Magne Olav (Peer reviewed; Journal article, 2020-05)Phenols and trans-1,2-dihydro-1,2-diols are metabolites commonly formed in vivo in fish upon exposure to polycyclic aromatic hydrocarbons (PAHs). These metabolites are excreted via the bile and gas chromatography-mass ... -
The crystal structure of haemoglobin from Atlantic cod
Helland, Ronny; Bjørkeng, Eva Katrin; Rothweiler, Ulli; Sydnes, Magne Olav; Pampanin, Daniela Maria (Journal article; Peer reviewed, 2019-06)The crystal structure of haemoglobin from Atlantic cod has been solved to 2.54 Å resolution. The structure consists of two tetramers in the crystallographic asymmetric unit. The structure of haemoglobin obtained from one ... -
The use of Palladium on Magnetic Support as Catalyst for Suzuki-Miyaura Cross-Coupling Reactions
Sydnes, Magne Olav (Journal article; Peer reviewed, 2017-01-23)The development of new solid supports for palladium has received a lot of interest lately. These catalysts have been tested in a range of cross-coupling reactions, such as Suzuki–Miyaura, Mizoroki-Heck, and Sonogashira ... -
Total synthesis of tubastrine and 3-dehydroxy tubastrine by microwave-assisted cross-coupling reactions
Lorentzen, Marianne; Bayer, Annette; Sydnes, Magne Olav; Jørgensen, Kåre Bredeli (Journal article, 2015-10)The first syntheses of tubastrine and 3-dehydroxy tubastrine are described. The target compounds were prepared in four consecutive steps from commercially available starting materials. The central scaffold was formed by a ...