Blar i UiS Brage på forfatter "Macleod, Angus D."

Viser treff 1-9 av 9

    • Association of GBA Genotype With Motor and Functional Decline in Patients With Newly Diagnosed Parkinson Disease. 

      Grødem, Jodi Maple; Dalen, Ingvild; Tysnes, Ole-Bjørn; Macleod, Angus D.; Forsgren, Lars; Counsell, Carl E.; Alves, Guido Werner (Peer reviewed; Journal article, 2020-12)
      Objective To establish the significance of glucocerebrosidase gene (GBA) carrier status on motor impairment in a large cohort of patients with incident Parkinson disease (PD). Methods Three European population-based ...

    • Association of SNCA Parkinson's Disease Risk Polymorphisms With Disease Progression in Newly Diagnosed Patients 

      Szwedo, Aleksandra A; Pedersen, Camilla C; Ushakova, Anastasia; Forsgren, Lars; Tysnes, Ole-Bjørn; Counsell, Carl E.; Alves, Guido Werner; Lange, Johannes; Macleod, Angus D.; Maple-Grødem, Jodi (Peer reviewed; Journal article, 2021-02)
      Objectives: To evaluate the impact of SNCA polymorphisms originally identified as risk factors for Parkinson's disease (PD) on the clinical presentation and progression of the disease in a large cohort of population-based ...

    • Cognitive and Motor Decline in Dementia with Lewy Bodies and Parkinson's Disease Dementia 

      Gonzalez Velez, Maria Camila; Tovar-Rios, Diego Alejandro; Alves, Guido Werner; Dalen, Ingvild; Williams-Gray, Caroline H.; Camacho, Marta; Forsgren, Lars; Bäckström, David; Lawson, Rachael A.; Macleod, Angus D.; Counsell, Carl E.; Paquet, Claire; DeLena, Carlo; D'Antonio, Fabrizia; Pilotto, Andrea; Padovani, Alessandro; Blanc, Frédéric; Falup-Pecurariu, Cristian; Lewis, Simon J.G.; Rejdak, Konrad; Papuc, Ewa; Hort, Jakub; Nedelska, Zuzana; O'Brien, John; Bonanni, Laura; Marquié, Marta; Boada, Mercè; Pytel, Vanesa; Abdelnour, Carla; Alcolea, Daniel; Beyer, Katrin; Tysnes, Ole-Bjørn; Aarsland, Dag; Maple-Grødem, Jodi (Peer reviewed; Journal article, 2023)
      Background There is a need to better understand the rate of cognitive and motor decline of Dementia with Lewy bodies (DLB) and Parkinson's disease Dementia (PDD). Objectives To compare the rate of cognitive and motor ...

    • Early constipation predicts faster dementia onset in Parkinson's disease 

      Camacho, Marta; Macleod, Angus D.; Grødem, Jodi Maple; Evans, Jonathan R.; Breen, David P.; Cummins, G; Wijeyekoon, Ruwani; Greenland, Julia; Alves, Guido Werner; Tysnes, Ole-Bjørn; Lawson, Rachel A.; Barker, Roger A.; Williams-Gray, Caroline H. (Peer reviewed; Journal article, 2021-05)
      Constipation is a common but not a universal feature in early PD, suggesting that gut involvement is heterogeneous and may be part of a distinct PD subtype with prognostic implications. We analysed data from the Parkinson’s ...

    • First delirium episode in Parkinson’s disease and parkinsonism: incidence, predictors, and outcomes 

      Green, Samantha; Perrott, Sarah L.; McCleary, Andrew; Sleeman, Isobel; Maple-Grødem, Jodi; Counsell, Carl E.; Macleod, Angus D. (Peer reviewed; Journal article, 2021-10)
      To define the incidence, predictors and prognosis of the first hospital delirium episode in Parkinson’s disease (PD) and atypical parkinsonism (AP), we identified the first hospital episode of delirium after diagnosis in ...

    • GBA and APOE Impact Cognitive Decline in Parkinson's Disease: A 10-Year Population-Based Study 

      Szwedo, Aleksandra Anna; Dalen, Ingvild; Pedersen, Kenn Freddy; Camacho, Marta; Bäckström, David; Forsgren, Lars; Tzoulis, Charalampos; Winder-Rhodes, Sophie; Hudson, Gavin; Liu, Ganqiang; Scherzer, Clemens R.; Lawson, Rachael A.; Yarnall, Alison J.; Williams-Gray, Caroline H.; Macleod, Angus D.; Counsell, Carl E.; Tysnes, Ole-Bjørn; Alves, Guido Werner; Maple-Grødem, Jodi (Peer reviewed; Journal article, 2022)
      Background Common genetic variance in apolipoprotein E (APOE), β-glucocerebrosidase (GBA), microtubule-associated protein tau (MAPT), and α-synuclein (SNCA) has been linked to cognitive decline in Parkinson's disease (PD), ...

    • The incidence, baseline predictors, and outcomes of dementia in an incident cohort of Parkinson’s disease and controls 

      Counsell, Carl; Giuntoli, Cinzia; Khan, Qaisar Imran; Maple-Grødem, Jodi; Macleod, Angus D. (Peer reviewed; Journal article, 2022)
      Background There are few long-term data on the incidence, baseline predictors, and outcomes of dementia in Parkinson’s disease (PD) from prospective community-based incident cohorts. Methods The PINE study prospectively ...

    • Lack of Association Between GBA Mutations and Motor Complications in European and American Parkinson's Disease Cohorts 

      Grødem, Jodi Maple; Paul, Kimberly C.; Dalen, Ingvild; Ngo, Kathie J.; Wong, Darice; Macleod, Angus D.; Counsell, Carl E.; Bäckström, David; Forsgren, Lars; Tysnes, Ole-Bjørn; Kusters, Cynthia D.J.; Fogel, Brent L.; Bronstein, Jeff M.; Ritz, Beate; Alves, Guido Werner (Peer reviewed; Journal article, 2021)
      Background: Motor complications are a consequence of the chronic dopaminergic treatment of Parkinson’s disease (PD) and include levodopa-induced dyskinesia (LIDs) and motor fluctuations (MF). Currently, evidence is on ...

    • A systematic review of associations between common SNCA variants and clinical heterogeneity in Parkinson's disease 

      Pedersen, Camilla C; Lange, Johannes; Førland, Marthe Gurine; Macleod, Angus D.; Alves, Guido Werner; Maple-Grødem, Jodi (Peer reviewed; Journal article, 2021-07)
      There is great heterogeneity in both the clinical presentation and rate of disease progression among patients with Parkinson’s disease (PD). This can pose prognostic difficulties in a clinical setting, and a greater ...