Blar i UiS Brage på forfatter "Nordgård, Oddmund"
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Clinical relevance of disseminated tumor cells in advanced pancreatic cancer
Bore Neverdahl, Nicolay (Bachelor thesis, 2021)Introduction Pancreatic ductal adenocarcinoma (PDAC), a particularly deadly form of pancreatic cancer (PC), continues to challenge modern medical science regarding diagnosis and treatment of the disease. The poor prognosis ... -
Comprehensive ctDNA Measurements Improve Prediction of Clinical Outcomes and Enable Dynamic Tracking of Disease Progression in Advanced Pancreatic Cancer
Lapin, Morten; Edland, Karin Hestnes; Tjensvoll, Kjersti; Oltedal, Satu; Austdal, Marie; Garresori, Herish; Rozenholc, Yves; Gilje, Bjørnar; Nordgård, Oddmund (Peer reviewed; Journal article, 2023)Purpose: Circulating tumor DNA (ctDNA) has emerged as a promising tumor-specific biomarker in pancreatic cancer, but current evidence of the clinical potential of ctDNA is limited. In this study, we used comprehensive ... -
Detection and Characterization of Circulating Tumor Cells in Early Breast Cancer
Tidwell, Tia (Masteroppgave/UIS-TN-IMN/2016;, Master thesis, 2016-06)Background: Detection of circulating tumor cells (CTCs) has demonstrated prognostic significance in metastatic breast cancer. This is less studied in early breast cancer due to the rarity of such cells in early disease and ... -
Extracellular vesicles as a potential source of tumor-derived DNA in advanced pancreatic cancer
Lapin, Morten; Tjensvoll, Kjersti; Nedrebø, Karoline; Taksdal, Eline; Janssen, Hans; Gilje, Bjørnar; Nordgård, Oddmund (Peer reviewed; Journal article, 2023)Tumor-derived extracellular vesicles (EVs) are reported to contain nucleic acids, including DNA. Several studies have highlighted the potential of EV-derived DNA (evDNA) as a circulating biomarker, even demonstrating that ... -
Interactions between platelets and hematopoietic cells
Cacic, Daniel Limi (PhD thesis UiS;, Doctoral thesis, 2022-04)In addition to their primary role in hemostasis, platelets are increasingly recognized as important participants in numerous biological processes. Their ability to adhere to and communicate with different immune cells, ... -
Isolation and Characterization of Exosomes from Cell Culture Medium and Human Plasma in Relation to Cancer Diagnostics
Ørnholt, Bjørn-Christian (Masteroppgave/UIS-TN-IKBM/2018;, Master thesis, 2018-06-15)The interest in exosomes and other extracellular vesicles (EVs) has been steadily increasing for the past several years, as a growing body of evidence for their potential use as non-invasive biomarkers for disease such as ... -
Liquid Biopsies in Solid Cancers: Implementation in a Nordic Healthcare System
Nordgård, Oddmund; Forthun, Rakel Brendsdal; Lapin, Morten; Grønberg, Bjørn Henning; Kalland, Karl Henning; Kopperud, Reidun Kristin; Thomsen, Liv Cecilie Vestrheim; Tjensvoll, Kjersti; Gilje, Bjørnar; Gjertsen, Bjørn Tore; Hovland, Randi (Peer reviewed; Journal article, 2021-04)Liquid biopsies have emerged as a potential new diagnostic tool, providing detailed information relevant for characterization and treatment of solid cancers. We here present an overview of current evidence supporting the ... -
Molecular subtypes in stage II-III colon cancer defined by genomic instability: Early recurrence-risk associated with a high copy-number variation and loss of RUNX3 and CDKN2A
Berg, Marianne; Nordgård, Oddmund; Kørner, Hartwig; Oltedal, Satu; Smaaland, Rune; Søreide, Jon Arne; Søreide, Kjetil (Journal article; Peer reviewed, 2015)Abstract Objective We sought to investigate various molecular subtypes defined by genomic instability that may be related to early death and recurrence in colon cancer. Methods We sought to investigate various ... -
Optimalisering av en størrelsesbasert anrikningsmetode for forbedret deteksjon av sirkulerende kreftceller i pasienter med metastatisk brystkreft
Anda, Sol Emilie (Bachelor thesis, 2023)Circulating tumour cells (CTCs) are tumour cells that have separated from the primary tumour or metastasis and entered the bloodstream. CTCs have shown to be promising diagnostic and prognostic biomarkers for several ... -
Platelet microparticles protect acute myelogenous leukemia cells against daunorubicin-induced apoptosis
Cacic, Daniel; Reikvam, Håkon; Nordgård, Oddmund; Meyer, Peter; Hervig, Tor (Peer reviewed; Journal article, 2021-04)The role of platelets in cancer development and progression is increasingly evident, and several platelet–cancer interactions have been discovered, including the uptake of platelet microparticles (PMPs) by cancer cells. ...