Blar i UiS Brage på forfatter "Hagland, Hanne Røland"
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Cyclic production of biocompatible few-layer graphene ink with in-line shear-mixing for inkjet-printed electrodes and Li-ion energy storage
Carey, Tian; Alhourani, Abdelnour; Tian, Ruiyuan; Seyedin, Shayan; Arbab, Adrees; Maughan, Jack; Šiller, Lidija; Horvath, Dominik; Kelly, Adam; Kaur, Harneet; Caffrey, Eoin; Kim, Jong M.; Hagland, Hanne Røland; Coleman, Jonathan (Peer reviewed; Journal article, 2022)The scalable production of two-dimensional (2D) materials is needed to accelerate their adoption to industry. In this work, we present a low-cost in-line and enclosed process of exfoliation based on high-shear mixing to ... -
Delivery of dichloroacetic acid to colorectal carcinoma cells using non-toxic metal-organic frameworks
Mogstad, Emily Rose (Master thesis, 2024)Cancer is one of the leading causes of death worldwide, and our battle with it is ongoing due to the sheer number of documented cancers and the difficulty of treating them as a whole. Dichloroacetic acid (DCA) has been ... -
Effects of Short Chain Fatty Acids Butyrate and Propionate on Colorectal Cancer Cell Lines in Combination with 5-FU Treatment and Glucose Starvation
Halvorsen, Camilla (Master thesis, 2024)Colorectal cancer (CRC) is an increasing global health concern, ranking as the third most common cancer worldwide and the second leading cause of cancer related mortality. One of the main risk factors for the development ... -
Elevated microsatellite alterations at selected tetranucleotides (EMAST) is not attributed to MSH3 loss in stage I-III colon cancer: An automated, digitalized assessment by immunohistochemistry of whole slides and hot spots
Watson, Martin; Lea, Dordi; Hagland, Hanne Røland; Søreide, Kjetil (Journal article; Peer reviewed, 2019-12)INTRODUCTION: EMAST is a poorly understood form of microsatellite instability (MSI) in colorectal cancer (CRC) for which loss of MSH3 has been proposed as the underlying mechanism, based on experimental studies. We aimed ... -
Elevated microsatellite alterations at selected tetranucleotides in early-stage colorectal cancers with and without high-frequency microsatellite instability: same, same but different?
Watson, Martin Matthew Christian; Lea, Dordi; Rewcastle, Emma; Hagland, Hanne Røland; Søreide, Kjetil (Journal article; Peer reviewed, 2016-02)Microsatellite instability (MSI) is associated with better prognosis in colorectal cancer (CRC). Elevated microsatellite alterations at selected tetranucleotides (EMAST) is a less-understood form of MSI. Here, we aim to ... -
Graphene-based phenformin carriers for cancer cell treatment: a comparative study between oxidized and pegylated pristine graphene in human cells and zebrafish.
Alhourani, Abdelnour; Førde, Jan-Lukas; Nasrollahzadeh, Mojdeh; Eichacker, Lutz Andreas; Herfindal, Lars; Hagland, Hanne Røland (Peer reviewed; Journal article, 2022)Graphene is an attractive choice for the development of an effective drug carrier in cancer treatment due to its high adsorption area and pH-responsive drug affinity. In combination with the highly potent metabolic drug ... -
Graphene-based phenformin carriers for cancer cell treatment: a comparative study between oxidized and pegylated pristine graphene in human cells and zebrafish†
Alhourani, Abdelnour; Førde, Jan-Lukas; Nasrollahzadeh, Mojdeh; Eichacker, Lutz Andreas; Herfindal, Lars; Hagland, Hanne Røland (Peer reviewed; Journal article, 2022)Graphene is an attractive choice for the development of an effective drug carrier in cancer treatment due to its high adsorption area and pH-responsive drug affinity. In combination with the highly potent metabolic drug ... -
Improved pH-Responsive Release of Phenformin from Low-Defect Graphene Compared to Graphene Oxide
Alhourani, Abdelnour; Førde, Jan-Lukas; Eichacker, Lutz Andreas; Herfindal, Lars; Hagland, Hanne Røland (Peer reviewed; Journal article, 2021-09)Graphene-based drug carriers provide a promising addition to current cancer drug delivery options. Increased accessibility of high-quality graphene made by plasma-enhanced chemical vapor deposition (PE-CVD) makes it an ... -
Lifestyle, Immune System and Their Role in Gut Microbiota and Colorectal Cancer
Furnée, Marte Bjerkreim (Bachelor thesis, 2024)Colorectal cancer (CRC) is a disease with a substantial public health challenge, originating in the colon or rectum, both crucial components of the digestive system. The development of CRC is influenced by a range of ... -
Metabolic Assessment of Metformin Treatment in Colon Cancer Cells
Alhourani, Abdelnour (Masteroppgave/UIS-TN-IMN/2017;, Master thesis, 2017-06-01)Resistance against traditional chemotherapy is a challenge in the treatment of colorectal cancer (CRC). The use of metformin, a commonly prescribed biguanide anti-diabetic drug, has shown to correlate with cancer preventive ... -
Metabolic flux analysis of 3D spheroids reveals significant differences in glucose metabolism from matched 2D cultures of colorectal cancer and pancreatic ductal adenocarcinoma cell lines
Tidwell, Tia R.; Røsland, Gro Vatne; Tronstad, Karl Johan; Søreide, Kjetil; Hagland, Hanne Røland (Peer reviewed; Journal article, 2022-05)Background Most in vitro cancer cell experiments have been performed using 2D models. However, 3D spheroid cultures are increasingly favored for being more representative of in vivo tumor conditions. To overcome the ... -
Mitochondrial Inhibitors CCCP, Rotenone and Oligomycin’s Effect on Pancreatic Cancer Cell Lines BxPC-3 and PANC-1.
Helgesen, Katrine; Bamerni, Sisen (Bachelor thesis, 2023)This bachelor thesis focuses on the effect of mitochondrial inhibitors CCCP, rotenone and oligomycin on the two different pancreatic cancer cell lines PANC-1 and BxPC-3. Cell viability was tested after the cells were exposed ... -
Mitochondrial Inhibitors CCCP, Rotenone and Oligomycin’s Effect on Pancreatic Cancer Cell Lines BxPC-3 and PANC-1.
Bamerni, Sisen; Helgesen, Katrine (Bachelor thesis, 2023)This bachelor thesis focuses on the effect of mitochondrial inhibitors CCCP, rotenone and oligomycin on the two different pancreatic cancer cell lines PANC-1 and BxPC-3. Cell viability was tested after the cells were exposed ... -
OCT1 expression in pancreatic cancer cell lines MIA PaCa-2 and Panc-1 after metformin and phenformin treatment
Vijayaratnam, Priya (Master thesis, 2021)Pancreatic cancer is the 13th most common types of cancer and has a poor prognosis of survival. Therefore, it is important further investigate different drugs, especially already well- establish medicaments response in ... -
Prevalence of PD‑L1 expression is associated with EMAST, density of peritumoral T‑cells and recurrence‑free survival in operable non‑metastatic colorectal cancer
Watson, Martin Matthew Christian; Lea, Dordi; Gudlaugsson, Einar; Skaland, Ivar; Hagland, Hanne Røland; Søreide, Kjetil (Peer reviewed; Journal article, 2020-08)Introduction Microsatellite instability (MSI) predict response to anti-PD1 immunotherapy in colorectal cancer (CRC). CRCs with MSI have higher infiltration of immune cells related to a better survival. Elevated Microsatellite ... -
A template to quantify the location and density of CD3 + and CD8 + tumor-infiltrating lymphocytes in colon cancer by digital pathology on whole slides for an objective, standardized immune score assessment
Lea, Dordi; Watson, Martin Matthew Christian; Skaland, Ivar; Hagland, Hanne Røland; Lillesand, Melinda; Gudlaugsson, Einar; Søreide, Kjetil (Peer reviewed; Journal article, 2021)Background In colon cancer, the location and density of tumor-infiltrating lymphocytes (TILs) can classify patients into low and high-risk groups for prognostication. While a commercially available ‘Immunoscore®’ exists, ... -
Triply periodic minimal surfaces based functionally graded biomimetic scaffold fabrication via stereolithography
Adugna, Yosef Wakjira; Lemu, Hirpa G.; Hagland, Hanne Røland (Peer reviewed; Journal article, 2023)Triply Periodic Minimal Surfaces (TPMS), a class of intricate mathematical surfaces, have emerged as a promising framework for scaffold design due to their ability to replicate the complex geometries found in biological ...