Browsing UiS Brage by Author "Søreide, Kjetil"
Now showing items 1-20 of 31
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3D in vitro cancer models for drug screening: A study of glucose metabolism and drug response in 2D and 3D culture models
Tidwell, Tia R. (PhD thesis UiS;, Doctoral thesis, 2022-03)Current drug screening protocols use in vitro cancer cell panels grown in 2D to evaluate drug response and select the most promising candidates for further in vivo testing. Most drug candidates fail at this stage, not ... -
Anastomotic leak after surgery for colon cancer and effect on long‐term survival
Stormark, Kjartan; Krarup, Peter-Martin; Sjövall, Annika; Søreide, Kjetil; Kvaløy, Jan Terje; Nordholm-Carstensen, Andreas; Nedrebø, Bjørn Steinar Olden; Kørner, Hartwig (Peer reviewed; Journal article, 2020-02)Aim An anastomotic leak after surgery for colon cancer is a recognized complication but how it may adversely affect long‐term survival is less clear because data are scarce. The aim of the study was to investigate the ... -
Comparison of performance score for female and male residents in general surgery doing supervised real-life laparoscopic appendectomy: Is there a Norse shield-maiden effect?
Skjold-Ødegaard, Benedicte; Ersdal, Hege Langli; Assmus, Jörg; Søreide, Kjetil (Peer reviewed; Journal article, 2021-01)Background Gender bias may represent a threat to resident assessment during surgical training, and there have been concerns that women might be disadvantaged. There is a lack of studies investigating gender differences ... -
Deciphering the inflection points to achieve proficiency for each procedure step during training in laparoscopic appendicectomy
Skjold-Ødegaard, B.; Hamid, S.; Lindeman, Robbert-Jan; Ersdal, H.L.; Søreide, Kjetil (Peer reviewed; Journal article, 2021-09)Background Laparoscopic appendicectomy is a common procedure early in surgical training. A minimum number is usually required for certification in general surgery. However, data on proficiency are scarce. This study aimed ... -
The diagnostic differentiation challenge in acute appendicitis: How to distinguish between uncomplicated and complicated appendicitis in adults
Skjold-Ødegaard, Benedicte; Søreide, Kjetil (Peer reviewed; Journal article, 2022)(1) Background: How to best define, diagnose and differentiate uncomplicated from complicated acute appendicitis remains debated. Hence, the aim of this review was to present an overview of the current knowledge and emerging ... -
Early Diagnosis of Pancreatic Cancer: Clinical Premonitions, Timely Precursor Detection and Increased Curative-Intent Surgery
Søreide, Kjetil; Ismail, Warsan; Roalsø, Marcus Thomas Thor; Ghotbi, Jacob; Zaharia, Claudia (Peer reviewed; Journal article, 2023)Background The overall poor prognosis in pancreatic cancer is related to late clinical detection. Early diagnosis remains a considerable challenge in pancreatic cancer. Unfortunately, the onset of clinical symptoms in ... -
Elevated microsatellite alterations at selected tetranucleotides (EMAST) is not attributed to MSH3 loss in stage I-III colon cancer: An automated, digitalized assessment by immunohistochemistry of whole slides and hot spots
Watson, Martin; Lea, Dordi; Hagland, Hanne Røland; Søreide, Kjetil (Journal article; Peer reviewed, 2019-12)INTRODUCTION: EMAST is a poorly understood form of microsatellite instability (MSI) in colorectal cancer (CRC) for which loss of MSH3 has been proposed as the underlying mechanism, based on experimental studies. We aimed ... -
Elevated microsatellite alterations at selected tetranucleotides in early-stage colorectal cancers with and without high-frequency microsatellite instability: same, same but different?
Watson, Martin Matthew Christian; Lea, Dordi; Rewcastle, Emma; Hagland, Hanne Røland; Søreide, Kjetil (Journal article; Peer reviewed, 2016-02)Microsatellite instability (MSI) is associated with better prognosis in colorectal cancer (CRC). Elevated microsatellite alterations at selected tetranucleotides (EMAST) is a less-understood form of MSI. Here, we aim to ... -
Emerging Role of Epigenetic Alterations as Biomarkers and Novel Targets for Treatments in Pancreatic Ductal Adenocarcinoma
Roalsø, Marcus Thomas Thor; Hald, Øyvind; Alexeeva, Marina; Søreide, Kjetil (Peer reviewed; Journal article, 2022-01)Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with limited treatment options. Emerging evidence shows that epigenetic alterations are present in PDAC. The changes are potentially reversible and therefore ... -
En ung mann med akutte magesmerter og anemi
Roalsø, Marcus Thomas Thor; Karlsen, Lars Normann; Buchmann, Petr; Haukås, Einar; Søreide, Kjetil (Peer reviewed; Journal article, 2023)En mann i midten av 20-årene ble innlagt på gastrokirurgisk avdeling etter ett døgns sykehistorie med måltidsrelaterte kolikksmerter under høyre kostalbue. Lignende smerteanfall var de siste to årene i primærhelsetjenesten ... -
Epidemiology and classification of gastroenteropancreatic neuroendocrine neoplasms using current coding criteria
Sandvik, Oddvar Mathias; Søreide, Kjetil; Gudlaugsson, Einar; Kvaløy, Jan Terje; Søreide, Jon Arne (Journal article; Peer reviewed, 2015-09)Background: The lack of uniform criteria for coding of gastroenteropancreatic neuroendocrine neoplasia (GEP-NEN) has hampered previous epidemiological studies. The epidemiology of GEP-NEN was investigated in this study ... -
Epidemiology of abdominal trauma: An age- and sex-adjusted incidence analysis with mortality patterns
Larsen, Johannes Wiik; Søreide, Kjetil; Søreide, Jon Arne; Tjosevik, Kjell E; Kvaløy, Jan Terje; Thorsen, Kenneth (Peer reviewed; Journal article, 2022)Purpose Abdominal injuries may occur in up to one-third of all patients who suffer severe trauma, but little is known about epidemiological trends and characteristics in a Northern European setting. This study investigated ... -
Fluid-sensitive migration mechanisms predict association between metastasis and high interstitial fluid pressure in pancreatic cancer
Nævdal, Geir; Rofstad, Einar K; Søreide, Kjetil; Evje, Steinar (Peer reviewed; Journal article, 2022)A remarkable feature in pancreatic cancer is the propensity to metastasize early, even for small, early stage cancers. We use a computer-based pancreatic model to simulate tumor progression behavior where fluid-sensitive ... -
Global surgery, obstetric, and anaesthesia indicator definitions and reporting: An Utstein consensus report
Davies, Justine I; Gelb, Adrian W.; Gore-Booth, Julian; Martin, Janet; Mellin-Olsen, Jannicke; Åkerman, Christina; Ameh, Emmanuel A.; Biccard, Bruce M.; Braut, Geir Sverre; Chu, Kathryn M.; Derbew, Miliard; Ersdal, Hege Langli; Guzman, Jose Miguel; Hagander, Lars; Haylock-Loor, Carolina; Holmer, Hampus; Johnson, Walter; Juran, Sabrina; Kassebaum, Nicolas J.; Lærdal, Tore; Leather, Andrew J.M.; Lipnick, Michael S.; Ljungman, David; Makasa, Emmanuel Malabo Mwenda; Meara, John G.; Newton, Mark W.; Østergaard, Doris; Reynolds, Teri; Romanzi, Lauri J.; Santhirapala, Vatshalan; Shrime, Mark G.; Søreide, Kjetil; Steinholt, Margit; Suzuki, Emi; Varallo, John E.; Visser, Gerard H.A.; Watters, David; Weiser, Thomas G. (Peer reviewed; Journal article, 2021)Background Indicators to evaluate progress towards timely access to safe surgical, anaesthesia, and obstetric (SAO) care were proposed in 2015 by the Lancet Commission on Global Surgery. These aimed to capture access to ... -
Health Care Implications of the COVID-19 Pandemic for Patients with Severe Traumatic Brain Injury-A Nationwide, Observational Cohort Study
Weber, Clemens; Werner, David Andreas Thomas; Thorsen, Kenneth; Søreide, Kjetil (Peer reviewed; Journal article, 2022-08)Background Containment measures during the coronavirus disease of 2019 (COVID-19) pandemic have resulted in a substantial reduction in treatment of injury. The effect of the COVID-19 pandemic on the epidemiology and ... -
Incidence, Mechanisms of Injury and Mortality of Severe Traumatic Brain Injury: An Observational Population-Based Cohort Study from New Zealand and Norway
Weber, Clemens; Andreassen, Joakim Stray; Isles, Siobhan; Thorsen, Kenneth; McBride, Paul; Søreide, Kjetil; Civil, Ian (Peer reviewed; Journal article, 2022)Background Comparing trauma registry data from different countries can help to identify possible differences in epidemiology, which may help to improve the care of trauma patients. Methods This study directly compares ... -
Internal and external factors affecting the performance score of surgical trainees doing laparoscopic appendectomy: a prospective, observational cohort study in a structured training programme
Skjold-Ødegaard, Benedicte; Ersdal, Hege Langli; Assmus, Jörg; Søreide, Kjetil (Peer reviewed; Journal article, 2024)Background Laparoscopic appendectomy is a common procedure and introduced early in general surgical training. How internal (i.e. surgeon’s experience) or external (i.e. disease severity) may affect procedure performance ... -
Is There a Trojan Horse to Aggressive Pancreatic Cancer Biology? A Review of the Trypsin-PAR2 Axis to Proliferation, Early Invasion, and Metastasis
Søreide, Kjetil; Roalsø, Marcus Thomas Thor; Aunan, Jan Rune (Peer reviewed; Journal article, 2020-02)Purpose: Pancreatic cancer is one of the most lethal of solid tumors and is associated with aggressive cancer biology. The purpose is to review the role of trypsin and effect on molecular and cellular processes potentially ... -
Is there a weekend effect on mortality rate and outcome for moderate and severe traumatic brain injury? A population-based, observational cohort study
Andreassen, Joakim Stray; Thorsen, Kenneth; Søreide, Kjetil; Werner, David Andreas Thomas; Weber, Clemens (Peer reviewed; Journal article, 2022)Purpose The aim of the study was to analyse patient and injury characteristics and the effects of weekend admissions on mortality rate and outcome after moderate and severe traumatic brain injuries. Methods This is ... -
Learning from experience: a qualitative study of surgeons’ perspectives on reporting and dealing with serious adverse events
Øyri, Sina Furnes; Søreide, Kjetil; Søreide, Eldar; Tjomsland, Ole (Peer reviewed; Journal article, 2023-06)Introduction In surgery, serious adverse events have effects on the patient journey, the patient outcome and may constitute a burden to the surgeon involved. This study aims to investigate facilitators and barriers to ...