Browsing UiS Brage by Author "Skaland, Ivar"
Now showing items 1-10 of 10
-
Digital Image Analysis of Ki-67 Stained Tissue Microarrays and Recurrence in Tamoxifen-Treated Breast Cancer Patients
Egeland, Nina Gran; Jonsdottir, Kristin; Lauridsen, Kristina Lystlund; Skaland, Ivar; Hjorth, Cathrine F.; Gudlaugsson, Einar; Hamilton-Dutoit, Stephen Jacques; Lash, Timothy L.; Cronin-Fenton, Deidre; Janssen, Emiel (Peer reviewed; Journal article, 2020-07)Purpose: The proliferation marker Ki-67 has been used as a prognostic marker to separate low- and high-risk breast cancer subtypes and guide treatment decisions for adjuvant chemotherapy. The association of Ki-67 with ... -
Influence of pre-operative oral carbohydrate loading vs. standard fasting on tumor proliferation and clinical outcome in breast cancer patients - a randomized trial
Lende, Tone Hoel; Austdal, Marie; Varhaugvik, Anne Elin; Skaland, Ivar; Gudlaugsson, Einar; Kvaløy, Jan Terje; Akslen, Lars A.; Søiland, Håvard; Janssen, Emiel; Baak, Jan P.A. (Journal article; Peer reviewed, 2019-11)Background Conflicting results have been reported on the influence of carbohydrates in breast cancer. Objective To determine the influence of pre-operative per-oral carbohydrate load on proliferation in breast ... -
Integrating Genetic Alterations and Histopathological Features for Enhanced Risk Stratification in Non-Muscle-Invasive Bladder Cancer
Lillesand, Melinda; Kvikstad, Vebjørn; Gudlaugsson, Einar; Skaland, Ivar; Slewa Johannessen, Aida; Tesfahun, Almaz Nigatu; Sperstad, Sigmund; Janssen, Emiel; Austdal, Marie (Peer reviewed; Journal article, 2024)Background: Urothelial carcinoma presents as non-muscle-invasive bladder cancer (NMIBC) in ~75% of primary cases. Addressing the limitations of the TNM and WHO04/16 classification systems, this study investigates genetic ... -
Metabolic consequences of perioperative oral carbohydrates in breast cancer patients - an explorative study
Lende, Tone Hoel; Austdal, Marie; Bathen, Tone Frost; Varhaugvik, Anne Elin; Skaland, Ivar; Gudlaugsson, Einar; Egeland, Nina Gran; Lunde, Siri; Akslen, Lars A.; Jonsdottir, Kristin; Janssen, Emiel; Søiland, Håvard; Baak, Jan P.A. (Journal article; Peer reviewed, 2019-12)Background The metabolic consequences of preoperative carbohydrate load in breast cancer patients are not known. The present explorative study investigated the systemic and tumor metabolic changes after preoperative ... -
MiR-18a and miR-18b are expressed in the stroma of oestrogen receptor alpha negative breast cancers
Egeland, Nina Gran; Jonsdottir, Kristin; Aure, Miriam Ragle; Sahlberg, Kristine Kleivi; Kristensen, Vessela N.; Cronin-Fenton, Deirdre; Skaland, Ivar; Gudlaugsson, Einar; Baak, Jan P.A.; Janssen, Emiel (Peer reviewed; Journal article, 2020-05)Background Previously, we have shown that miR-18a and miR-18b gene expression strongly correlates with high proliferation, oestrogen receptor -negativity (ER−), cytokeratin 5/6 positivity and basal-like features of breast ... -
Mitotic activity index and CD25+ lymphocytes predict risk of stage progression in non-muscle invasive bladder cancer
Lillesand, Melinda; Kvikstad, Vebjørn; Mangrud, Målfrid Ok; Gudlaugsson, Einar; Van Diermen, Bianca; Skaland, Ivar; Baak, Johannes Peter A; Janssen, Emiel (Peer reviewed; Journal article, 2020-06)In urothelial cell type non-muscle invasive urinary bladder carcinoma, TNM stage and WHO grade are widely used to classify patients into low and high-risk groups for prognostic and therapeutic decision-making. However, ... -
Prevalence of PD‑L1 expression is associated with EMAST, density of peritumoral T‑cells and recurrence‑free survival in operable non‑metastatic colorectal cancer
Watson, Martin Matthew Christian; Lea, Dordi; Gudlaugsson, Einar; Skaland, Ivar; Hagland, Hanne Røland; Søreide, Kjetil (Peer reviewed; Journal article, 2020-08)Introduction Microsatellite instability (MSI) predict response to anti-PD1 immunotherapy in colorectal cancer (CRC). CRCs with MSI have higher infiltration of immune cells related to a better survival. Elevated Microsatellite ... -
Proliferation and immunohistochemistry for p53, CD25 and CK20 in predicting prognosis of non-muscle invasive papillary urothelial carcinomas
Kvikstad, Vebjørn; Lillesand, Melinda; Gudlaugsson, Einar; Mangrud, Ok Målfrid; Rewcastle, Emma; Skaland, Ivar; Baak, Jan P.A.; Janssen, Emiel (Peer reviewed; Journal article, 2024)Non-muscle invasive papillary urothelial carcinoma is a prevalent disease with a high recurrence tendency. Good prognostic and reproducible biomarkers for tumor recurrence and disease progression are lacking. Currently, ... -
A template to quantify the location and density of CD3 + and CD8 + tumor-infiltrating lymphocytes in colon cancer by digital pathology on whole slides for an objective, standardized immune score assessment
Lea, Dordi; Watson, Martin Matthew Christian; Skaland, Ivar; Hagland, Hanne Røland; Lillesand, Melinda; Gudlaugsson, Einar; Søreide, Kjetil (Peer reviewed; Journal article, 2021)Background In colon cancer, the location and density of tumor-infiltrating lymphocytes (TILs) can classify patients into low and high-risk groups for prognostication. While a commercially available ‘Immunoscore®’ exists, ... -
Validation study of MARCKSL1 as a prognostic factor in lymph node-negative breast cancer patients
Egeland, Nina Gran; Austdal, Marie; Van Diermen, Bianca; Rewcastle, Emma; Gudlaugsson, Einar; Baak, Jan P.A.; Skaland, Ivar; Janssen, Emiel; Jonsdottir, Kristin (Peer reviewed; Journal article, 2019)Protein expression of Myristoylated alanine-rich C kinase substrate like-1 (MARCKSL1) has been identified as a prognostic factor in lymph-node negative (LN-) breast cancer patients. We aim to validate MARCKSL1 protein ...