Browsing UiS Brage by Author "Lange, Johannes"
Now showing items 1-17 of 17
-
Alpha-synuclein biomarkers of Parkinson's disease risk and heterogeneity
Pedersen, Camilla Christina (Masteroppgave/UIS-TN-IKBM/2020;, Master thesis, 2020-06)Parkinson’s disease (PD) is the second most common neurodegenerative disease and is the world’s fastest growing neurological disorder. PD is a motor disease, but many patients experience a range of non-motor features, ... -
Analysis of ceulluar events in a cell model for neurodegenerative diseases involving mitochondrial damage
Gautam, Sumit (Master thesis, 2017-06-09)Mitochondria are highly dynamic organelles, with an essential role in proper cell function. Increasing evidence points towards a key role of mitochondria and its bioenergetic state for pathogenesis of neurodegenerative ... -
Association of a BACE1 gene polymorphism with Parkinson’s disease in a Norwegian population
Lange, Johannes; Lunde, Kristin Aaser; Sletten, Camilla Johanne; Møller, Simon Geir; Tysnes, Ole-Bjørn; Alves, Guido; Larsen, Jan Petter; Maple-Grødem, Jodi (Journal article; Peer reviewed, 2015-11)Background . Parkinson’s disease (PD) and Alzheimer’s disease (AD) share pathological features, including amyloid-beta pathology. Amyloid-beta peptide is generated by sequential proteolysis of amyloid precursor protein ... -
Association of CSF Glucocerebrosidase Activity With the Risk of Incident Dementia in Patients With Parkinson Disease
Oftedal, Linn Silje Wathne; Maple-Grødem, Jodi; Dalen, Ingvild; Tysnes, Ole-Bjørn; Pedersen, Kenn Freddy; Alves, Guido Werner; Lange, Johannes (Peer reviewed; Journal article, 2022)Background and Objectives Variations in the glucocerebrosidase gene (GBA) are common risk factors for Parkinson disease (PD) and dementia in PD (PDD) and cause a reduction in the activity of the lysosomal enzyme ... -
Association of SNCA Parkinson's Disease Risk Polymorphisms With Disease Progression in Newly Diagnosed Patients
Szwedo, Aleksandra A; Pedersen, Camilla C; Ushakova, Anastasia; Forsgren, Lars; Tysnes, Ole-Bjørn; Counsell, Carl E.; Alves, Guido Werner; Lange, Johannes; Macleod, Angus D.; Maple-Grødem, Jodi (Peer reviewed; Journal article, 2021-02)Objectives: To evaluate the impact of SNCA polymorphisms originally identified as risk factors for Parkinson's disease (PD) on the clinical presentation and progression of the disease in a large cohort of population-based ... -
Cognitive Profile in Parkinson’s Disease Dementia Patients with Low versus Normal Cerebrospinal Fluid Amyloid Beta
Tufekcioglu, Zeynep; Lange, Johannes; Pedersen, Kenn Freddy; Tysnes, Ole-Bjørn; Alves, Guido Werner; Emre, Murat (Peer reviewed; Journal article, 2023)Introduction: In patients with Parkinson’s disease (PD), low cerebrospinal fluid (CSF) amyloid beta 1-42 (Ab42) at baseline is the most consistent CSF biomarker as a risk factor for developing dementia. Low CSF Ab42 is, ... -
Combinatory microRNA serum signatures as classifiers of Parkinson's disease
Patil, Ketan S.; Basak, Indranil; Dalen, Ingvild; Hoedt, Esthelle; Lange, Johannes; Lunde, Kristin Aaser; Liu, Ying; Tysnes, Ole-Bjørn; Forsgren, Lars; Aarsland, Dag; Neubert, Thomas A.; Larsen, Jan Petter; Alves, Guido Werner; Møller, Simon Geir (Journal article; Peer reviewed, 2019-04)As current clinical diagnostic protocols for Parkinson's disease (PD) may be prone to inaccuracies there is a need to identify and validate molecular biomarkers, such as circulating microRNAs, which will complement current ... -
Identification of diagnostic and prognostic biomarkers of PD using a multiplex proteomics approach
Maple-Grødem, Jodi; Ushakova, Anastasia; Pedersen, Kenn Freddy; Tysnes, Ole-Bjørn; Alves, Guido Werner; Lange, Johannes (Peer reviewed; Journal article, 2023-10)Given the complexity of Parkinson's disease (PD), achieving acceptable diagnostic and prognostic accuracy will require the support of a panel of diverse biomarkers. We used Proximity extension assays to measure a panel of ... -
Identification of diagnostic and prognostic biomarkers of PD using a multiplex proteomics approach
Maple-Grødem, Jodi; Ushakova, Anastasia; Pedersen, Kenn Freddy; Tysnes, Ole-Bjørn; Alves, Guido Werner; Lange, Johannes (Peer reviewed; Journal article, 2023-09)Given the complexity of Parkinson's disease (PD), achieving acceptable diagnostic and prognostic accuracy will require the support of a panel of diverse biomarkers. We used Proximity extension assays to measure a panel of ... -
Inflammatory biomarkers in newly diagnosed patients with Parkinson’s disease and related neurodegenerative disorders
Pedersen, Camilla Christina; Ushakova, Anastasia; Skogseth, Ragnhild Eide; Alves, Guido Werner; Tysnes, Ole-Bjørn; Aarsland, Dag; Lange, Johannes; Maple-Grødem, Jodi (Peer reviewed; Journal article, 2023)Background and Objectives Neuroinflammation contributes to Parkinson disease (PD) pathology, and inflammatory biomarkers may aid in PD diagnosis. Proximity extension assay (PEA) technology is a promising method for multiplex ... -
Kynurenines, Neuropsychiatric Symptoms, and Cognitive Prognosis in Patients with Mild Dementia
Solvang, Stein-Erik Hafstad; Nordrehaug, Jan Erik; Aarsland, Dag; Lange, Johannes; Ueland, Per Magne; McCann, Adrian; Midttun, Øivind; Tell, Grethe S.; Melvær, Giil Lasse (Journal article; Peer reviewed, 2019-09)Introduction: Circulating tryptophan (Trp) and its downstream metabolites, the kynurenines, are potentially neuroactive. Consequently, they could be associated with neuropsychiatric symptoms and cognitive prognosis in ... -
Method development for the extraction of pure intact mitochondria from beef heart and liver, and from HL-60 cultured cells.
Knutsen, Harald Meidell (Masteroppgave/UIS-TN-IKBM/2019;, Master thesis, 2019-06)Mitochondria have an essential role in the preservation of life. Life persists as a result of structure and energy, and the mitochondria are key components of energy production. Mitochondrial dysfunction is considered a ... -
Seed Amplification Assay as a Diagnostic Tool in Newly-Diagnosed Parkinson's Disease
Oftedal, Linn Silje Wathne; Maple-Gørdem, Jodi; Tysnes, Ole-Bjørn; Alves, Guido Werner; Lange, Johannes (Peer reviewed; Journal article, 2023)Seed amplification assays (SAA) are the first credible molecular assay for Parkinson’s disease (PD). However, the value of SAA to support the clinicians’ initial diagnosis of PD is not clear. In our study, we analyzed ... -
A systematic review of associations between common SNCA variants and clinical heterogeneity in Parkinson's disease
Pedersen, Camilla C; Lange, Johannes; Førland, Marthe Gurine; Macleod, Angus D.; Alves, Guido Werner; Maple-Grødem, Jodi (Peer reviewed; Journal article, 2021-07)There is great heterogeneity in both the clinical presentation and rate of disease progression among patients with Parkinson’s disease (PD). This can pose prognostic difficulties in a clinical setting, and a greater ... -
The possible role of SCARB2/LIMP-2 in Parkinson´s disease
Bru, Karina Fuglestein (Master thesis, 2021)Parkinson disease (PD) is a common neurodegenerative disease and associated with pronounced loss of dopaminergic (DA) neurons in a region of the brain. The disease has been found to be caused by a combination of genetic ... -
The value of cerebrospinal fluid alpha-synuclein and the tau/alpha-synuclein ratio for diagnosis of neurodegenerative disorders with Lewy pathology
Førland, Marthe Gurine; Tysnes, Ole-Bjørn; Aarsland, Dag; Maple-Grødem, Jodi; Pedersen, Kenn Freddy; Alves, Guido Werner; Lange, Johannes (Journal article; Peer reviewed, 2019-07)Background and purpose Parkinson's disease (PD), dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) are three of the most common neurodegenerative disorders. Up to 20% of these patients have the wrong diagnosis, ... -
Validation and assessment of preanalytical factors of a fluorometric in vitro assay for glucocerebrosidase activity in human cerebrospinal fluid
Oftedal, Linn; Maple-Grødem, Jodi; Førland, Marthe Gurine; Alves, Guido Werner; Lange, Johannes (Peer reviewed; Journal article, 2020-12)Lysosomal dysfunction is an emerging feature in the pathology of Parkinson’s disease and Dementia with Lewy bodies. Mutations in the GBA gene, encoding the enzyme Glucocerebrosidase (GCase), have been identified as a genetic ...