Association of a BACE1 gene polymorphism with Parkinson’s disease in a Norwegian population

Lange, Johannes; Lunde, Kristin Aaser; Sletten, Camilla Johanne; Møller, Simon Geir; Tysnes, Ole-Bjørn; Alves, Guido; Larsen, Jan Petter; Maple-Grødem, Jodi
Journal article, Peer reviewed
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URI
http://hdl.handle.net/11250/2381876
Date
2015-11
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Original version
Lange, J. et al. (2015) Association of a BACE1 Gene Polymorphism with Parkinson’s disease in a Norwegian population. Parkinson's Disease, volume 2015, article ID 973298   10.1155/2015/973298
Abstract
Background

. Parkinson’s disease (PD) and Alzheimer’s disease (AD) share pathological features, including amyloid-beta pathology.

Amyloid-beta peptide is generated by sequential proteolysis of amyloid precursor protein (APP), and genetic variations in the

processing pathway genes have been found to increase the risk of AD; however, the contribution in PD is unknown.

Methods

.

The aim of this study was to investigate whether candidate polymorphisms in five genes (

ADAM10

,

BACE1

,

BACE2

,

PSEN2

,and

CLU

) involved in the APP processing pathway affect PD risk in a population-based cohort of patients with incident PD and control

subjects from the Norwegian ParkWest study.

Results

.Wefoundanassociationofrs638405in

BACE1

with increased risk of PD,

thus providing a novel link, at the genetic level, between amyloid-beta pathology and PD.
Description
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Publisher
Hindawi Publishing Corporation
Journal
Parkinson's Disease
Copyright
Copyright © 2015 Johannes Lange et al.
Navngivelse 3.0 Norge
Except where otherwise noted, this item's license is described as Navngivelse 3.0 Norge