Association of a BACE1 gene polymorphism with Parkinson’s disease in a Norwegian population
Journal article, Peer reviewed
MetadataShow full item record
Original versionLange, J. et al. (2015) Association of a BACE1 Gene Polymorphism with Parkinson’s disease in a Norwegian population. Parkinson's Disease, volume 2015, article ID 973298 10.1155/2015/973298
Background . Parkinson’s disease (PD) and Alzheimer’s disease (AD) share pathological features, including amyloid-beta pathology. Amyloid-beta peptide is generated by sequential proteolysis of amyloid precursor protein (APP), and genetic variations in the processing pathway genes have been found to increase the risk of AD; however, the contribution in PD is unknown. Methods . The aim of this study was to investigate whether candidate polymorphisms in five genes ( ADAM10 , BACE1 , BACE2 , PSEN2 ,and CLU ) involved in the APP processing pathway affect PD risk in a population-based cohort of patients with incident PD and control subjects from the Norwegian ParkWest study. Results .Wefoundanassociationofrs638405in BACE1 with increased risk of PD, thus providing a novel link, at the genetic level, between amyloid-beta pathology and PD.
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.