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Association of a BACE1 gene polymorphism with Parkinson’s disease in a Norwegian population

dc.contributor.authorLange, Johannes
dc.contributor.authorLunde, Kristin Aaser
dc.contributor.authorSletten, Camilla Johanne
dc.contributor.authorMøller, Simon Geir
dc.contributor.authorTysnes, Ole-Bjørn
dc.contributor.authorAlves, Guido
dc.contributor.authorLarsen, Jan Petter
dc.contributor.authorMaple-Grødem, Jodi
dc.date.accessioned2016-02-04T08:45:37Z
dc.date.accessioned2016-03-09T14:01:43Z
dc.date.available2016-02-04T08:45:37Z
dc.date.available2016-03-09T14:01:43Z
dc.date.issued2015-11
dc.identifier.citationLange, J. et al. (2015) Association of a BACE1 Gene Polymorphism with Parkinson’s disease in a Norwegian population. Parkinson's Disease, volume 2015, article ID 973298nb_NO
dc.identifier.issn2042-0080
dc.identifier.urihttp://hdl.handle.net/11250/2381876
dc.descriptionThis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.nb_NO
dc.description.abstractBackground . Parkinson’s disease (PD) and Alzheimer’s disease (AD) share pathological features, including amyloid-beta pathology. Amyloid-beta peptide is generated by sequential proteolysis of amyloid precursor protein (APP), and genetic variations in the processing pathway genes have been found to increase the risk of AD; however, the contribution in PD is unknown. Methods . The aim of this study was to investigate whether candidate polymorphisms in five genes ( ADAM10 , BACE1 , BACE2 , PSEN2 ,and CLU ) involved in the APP processing pathway affect PD risk in a population-based cohort of patients with incident PD and control subjects from the Norwegian ParkWest study. Results .Wefoundanassociationofrs638405in BACE1 with increased risk of PD, thus providing a novel link, at the genetic level, between amyloid-beta pathology and PD.nb_NO
dc.language.isoengnb_NO
dc.publisherHindawi Publishing Corporationnb_NO
dc.rightsNavngivelse 3.0 Norge*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/no/*
dc.subjectParkinsons sykdomnb_NO
dc.subjectAlzheimers sykdomnb_NO
dc.subjectnevrodegenerativ sykdomnb_NO
dc.titleAssociation of a BACE1 gene polymorphism with Parkinson’s disease in a Norwegian populationnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.date.updated2016-02-04T08:45:36Z
dc.rights.holderCopyright © 2015 Johannes Lange et al.nb_NO
dc.subject.nsiVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Neurology: 752nb_NO
dc.source.volume2015nb_NO
dc.source.journalParkinson's Diseasenb_NO
dc.identifier.doi10.1155/2015/973298
dc.identifier.cristin1306467


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