dc.contributor.author | Lange, Johannes | |
dc.contributor.author | Lunde, Kristin Aaser | |
dc.contributor.author | Sletten, Camilla Johanne | |
dc.contributor.author | Møller, Simon Geir | |
dc.contributor.author | Tysnes, Ole-Bjørn | |
dc.contributor.author | Alves, Guido | |
dc.contributor.author | Larsen, Jan Petter | |
dc.contributor.author | Maple-Grødem, Jodi | |
dc.date.accessioned | 2016-02-04T08:45:37Z | |
dc.date.accessioned | 2016-03-09T14:01:43Z | |
dc.date.available | 2016-02-04T08:45:37Z | |
dc.date.available | 2016-03-09T14:01:43Z | |
dc.date.issued | 2015-11 | |
dc.identifier.citation | Lange, J. et al. (2015) Association of a BACE1 Gene Polymorphism with Parkinson’s disease in a Norwegian population. Parkinson's Disease, volume 2015, article ID 973298 | nb_NO |
dc.identifier.issn | 2042-0080 | |
dc.identifier.uri | http://hdl.handle.net/11250/2381876 | |
dc.description | This is an open access article distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | nb_NO |
dc.description.abstract | Background
. Parkinson’s disease (PD) and Alzheimer’s disease (AD) share pathological features, including amyloid-beta pathology.
Amyloid-beta peptide is generated by sequential proteolysis of amyloid precursor protein (APP), and genetic variations in the
processing pathway genes have been found to increase the risk of AD; however, the contribution in PD is unknown.
Methods
.
The aim of this study was to investigate whether candidate polymorphisms in five genes (
ADAM10
,
BACE1
,
BACE2
,
PSEN2
,and
CLU
) involved in the APP processing pathway affect PD risk in a population-based cohort of patients with incident PD and control
subjects from the Norwegian ParkWest study.
Results
.Wefoundanassociationofrs638405in
BACE1
with increased risk of PD,
thus providing a novel link, at the genetic level, between amyloid-beta pathology and PD. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Hindawi Publishing Corporation | nb_NO |
dc.rights | Navngivelse 3.0 Norge | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/no/ | * |
dc.subject | Parkinsons sykdom | nb_NO |
dc.subject | Alzheimers sykdom | nb_NO |
dc.subject | nevrodegenerativ sykdom | nb_NO |
dc.title | Association of a BACE1 gene polymorphism with Parkinson’s disease in a Norwegian population | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.date.updated | 2016-02-04T08:45:36Z | |
dc.rights.holder | Copyright © 2015 Johannes Lange et al. | nb_NO |
dc.subject.nsi | VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Neurology: 752 | nb_NO |
dc.source.volume | 2015 | nb_NO |
dc.source.journal | Parkinson's Disease | nb_NO |
dc.identifier.doi | 10.1155/2015/973298 | |
dc.identifier.cristin | 1306467 | |