Blar i UiS Brage på forfatter "Brede, Cato"
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Determination of eleven steroid hormones and bioavailable testosterone in human serum using salting-out assisted liquid-liquid extraction with UHPLC-MS/MS
Ramos, Marliet (Master thesis, 2023)Steroid hormones are essential in various biological roles such as the regulation of sexual maturation, fertility, bone and muscle growth, stress-mediated responses, and inflammation, to name a few examples. Impaired ... -
Exploring potential analytical methods for determination of glycerol-3-phosphate in human plasma
Servan, Mathilde Nystuen (Master thesis, 2023)Chronic kidney disease (CKD) is a progressive condition where the kidneys gradually lose their ability to function properly. Biomarkers that indicate immediate renal tissue injury is needed for improved detection of early ... -
Fatigue in primary Sjögren's syndrome: A proteomic pilot study of cerebrospinal fluid
Larssen, Eivind; Brede, Cato; Hjelle, Anne; Tjensvoll, Anne Bolette; Norheim, Katrine Brække; Bårdsen, Kjetil; Jonsdottir, Kristin; Ruoff, Peter; Omdal, Roald; Nilsen, Mari Mæland (Peer reviewed; Journal article, 2019-05)Objectives: Fatigue is a frequent and often disabling phenomenon that occurs in patients with chronic inflammatory and immunological diseases, and the underlying biological mechanisms are largely unknown. Because fatigue ... -
Hepcidin analysis in pneumonia: Comparison of immunoassay and LC-MS/MS
Oppen, Kjersti; Brede, Cato; Skadberg, Øyvind; Steinsvik, Trude; Holter, Jan Cato; Michelsen, Annika Elisabet; Heggelund, Lars (Peer reviewed; Journal article, 2023-02)Background The iron-regulatory hormone hepcidin is a promising biomarker to differentiate anaemia of inflammation from iron deficiency. Plasma hepcidin concentrations increase substantially during inflammation, and the ... -
Hepcidin analysis in pneumonia: Comparison of immunoassay and LC-MS/MS
Oppen, Kjersti; Brede, Cato; Skadberg, Øyvind; Steinsvik, Trude; Holter, Jan Cato; Michelsen, Annika Elisabet; Heggelund, Lars (Peer reviewed; Journal article, 2023)Background The iron-regulatory hormone hepcidin is a promising biomarker to differentiate anaemia of inflammation from iron deficiency. Plasma hepcidin concentrations increase substantially during inflammation, and the ... -
Hepcidin and ferritin predict microbial etiology in community-acquired pneumonia
Oppen, Kjersti; Ueland, Thor; Siljan, William Ward; Skadberg, Øyvind; Brede, Cato; Lauritzen, Trine; Aukrust, Pål; Steinsvik, Trude; Husebye, Einar; Michelsen, Annika; Holter, Jan Cato; Heggelund, Lars (Peer reviewed; Journal article, 2021-02)Background Iron is crucial for survival and growth of microbes. Consequently, limiting iron availability is a human antimicrobial defense mechanism. We explored iron and iron-related proteins as potential biomarkers in ... -
Hepcidin predicts 5-year mortality after community-acquired pneumonia
Oppen, Kjersti; Ueland, Thor; Michelsen, Annika Elisabet; Aukrust, Pål; Steinsvik, Trude; Skadberg, Øyvind; Brede, Cato; Siljan, William Ward; Husebye, Einar; Holter, Jan Cato; Heggelund, Lars (Peer reviewed; Journal article, 2022)Background Virtually all living organisms, including microbes and humans, depend on iron to survive and grow. During an infection, the plasma level of iron and several iron-related proteins change substantially. We ... -
Interleukin-1-related activity and hypocretin-1 in cerebrospinal fluid contribute to fatigue in primary Sjögren's syndrome
Bårdsen, Kjetil; Brede, Cato; Kvivik, Ingeborg; Kvaløy, Jan Terje; Jonsdottir, Kristin; Tjensvoll, Anne Bolette; Ruoff, Peter; Omdal, Roald (Peer reviewed; Journal article, 2019)Background Fatigue is a common and sometimes debilitating phenomenon in primary Sjögren’s syndrome (pSS) and other chronic inflammatory diseases. We aimed to investigate how IL-1 β-related molecules and the neuropeptide ... -
Interleukin-1β, heat shock protein 90α, and hypocretin-1 in chronic fatigue
Bårdsen, Kjetil (PhD thesis UiS;505, Doctoral thesis, 2020-09)Background: Fatigue, defined as an overwhelming sense of tiredness, lack of energy, and feeling of exhaustion, is a phenomenon many people have experienced in connection with infections such as influenza, Epstein-Barr ... -
Major bioactive chemical compounds in Astragali Radix samples from different vendors vary greatly
Kafle, Bijay; Baak, Jan P.A.; Brede, Cato (Peer reviewed; Journal article, 2021-07)The worldwide traditional Chinese medicine (TCM) herbs sales figures have increased considerably to 50 billion US$ (2018). Astragali Radix (AR) is amongst the most often sold TCM herbs; sales in the European Union (EU) ... -
Monitoring farmed fish welfare by measurement of cortisol as a stress marker in fish feces by liquid chromatography coupled with tandem mass spectrometry
Meling, Vanessa Andrea; Berge, Kjetil; Knudsen, David Lausten; Rønning, Per Ola; Brede, Cato (Peer reviewed; Journal article, 2022-04)The aquaculture industry has become a sustainable source of food for humans. Remaining challenges include disease issues and ethical concerns for the discomfort and stress of farmed fish. There is a need for reliable ... -
Quantification by LC–MS/MS of astragaloside IV and isoflavones in Astragali radix can be more accurate by using standard addition
Kafle, Bijay; Baak, Jan P.A.; Brede, Cato (Peer reviewed; Journal article, 2020)Introduction Astragali radix (AR), the root of Astragalus, is an important medical herb widely used in traditional Chinese medicine. Bioactive components include isoflavones and a unique class of triterpenoid saponins ... -
Salting-Out Assisted Liquid-Liquid Extraction for UPLC-MS/MS Determination of Thyroxine and Steroid Hormones in Human Serum and Fish Plasma
Urge, Alemnesh Yirda; Pampanin, Daniela Maria; Martino, Maria Elena; Knudsen, David Lausten; Brede, Cato (Peer reviewed; Journal article, 2023)Measuring the level of steroid and thyroxine hormones is key to understanding organism health conditions. Liquid chromatography coupled with tandem mass spectrometry has become the method of choice for such hormone analyses ... -
Sammenheng mellom dentalt plakk og forkalkninger i arterievegger
Volkova, Olga (Bachelor thesis, 2022) -
Sample Preparation Strategies for Antibody-Free Quantitative Analysis of High Mobility Group Box 1 Protein
Kvivik, Ingeborg; Jonsson, Grete; Omdal, Roald; Brede, Cato (Peer reviewed; Journal article, 2021-06)Sickness behavior and fatigue are induced by cerebral mechanisms involving inflammatory cytokines. High mobility group box 1 (HMGB1) is an alarmin, and a potential key player in this process. Reliable quantification methods ...