Blar i UiS Brage på forfatter "Jørgensen, Kåre Bredeli"
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Alkyl-phenanthrenes in early life stage fish: differential toxicity in Atlantic haddock (Melanogrammus aeglefinus) embryos
Donald, Carey; Nakken, Charlotte L.; Sørhus, Elin; Perrichon, Prescilla; Jørgensen, Kåre Bredeli; Bjelland, Hege Kristoffersen; Stølen, Christine; Kancherla, Sindhu; Mayer, Philipp; Meier, Sonnich (Peer reviewed; Journal article, 2023)Tricyclic polycyclic aromatic hydrocarbons (PAHs) are believed to be the primary toxic components of crude oil. Such compounds including phenanthrene are known to have direct effects on cardiac tissue, which lead to ... -
Atropisomerism in Tertiary Biaryl 2-Amides: A Study of Ar-CO and Ar-Ar? Rotational Barriers
Lorentzen, Marianne; Kalvet, Indrek; Sauriol, Francoise; Rantanen, Toni; Jørgensen, Kåre Bredeli; Snieckus, Victor (Peer reviewed; Journal article, 2017)A rotational barrier study was performed on eight tertiary biaryl 2-amides using variable temperature (VT) NMR and exchange (EXSY) spectroscopy experiments. Seven out of the eight 2-amido-2′-methylbiphenyls with additional ... -
Detection of Nrf2 in peripheral blood mononuclear cells: comparison and application of two methods
Nguyen, Phuong Tuyet (Masteroppgave/UIS-TN-IKBM/2018;, Master thesis, 2018-11-01)Protein nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates expression of numerous proteins. These proteins protect cells against oxidative stress and reinstate cellular homeostasis. ... -
Directed ortho-Metalation and Anionic ortho-Fries Rearrangement of Polycyclic Aromatic O-Carbamates: Regioselective Synthesis of Substituted Chrysenes
Kancherla, Sindhu; Lorentzen, Marianne; Snieckus, Victor; Jørgensen, Kåre Bredeli (Peer reviewed; Journal article, 2018-03)A general method for the regioselective synthesis of a series of ortho-substituted chrysenyl N,N-diethyl-O-carbamates by the directed ortho-metalation (DoM) strategy is reported. The starting O-carbamates were prepared ... -
Enantioselective synthesis of (-)-(1R,2R)-1,2-dihydrochrysene-1,2-diol
Lorentzen, Marianne; Sydnes, Magne Olav; Jørgensen, Kåre Bredeli (Peer reviewed; Journal article, 2014)A general chiral building block containing the 1R,2R-trans-diol moiety was constructed utilizing the stereoselective Shi-epoxidation reaction on a tetralone scaffold assembled by a Negishi cross-coupling on N,N-diethylbenzamide. ... -
Gass-separasjon og CO2-fangst med organiske "bur"-molekyler
Bru, Håkon Olsen (Master thesis, 2022)Formålet med denne hovedoppgaven er å gi en innføring i bur-molekyler og deres potensiale for bruk i gass-separasjoner, hovedsakelig separasjon av klimagassen CO2. Oppgaven starter med å fastsette viktigheten og potensialet ... -
Kinase chemodiversity from the Arctic: the breitfussins
Østnes Hansen, Kine; Andersen, Jeanette hammer; Bayer, Annette; Pandey, Sunil Kumar; Lorentzen, Marianne; Jørgensen, Kåre Bredeli; Sydnes, Magne Olav; Guttormsen, Yngve; Baumann, Matthias; Koch, Uwe; Klebl, Bert; Eickhoff, Jan; Haug, Bengt Erik; Isaksson, Johan; Hansen, Espen (Journal article; Peer reviewed, 2019-10)In this work, we demonstrate that the indole-oxazole-pyrrole framework of the breitfussin family of natural products is a promising scaffold for kinase inhibition. Six new halogenated natural products, breitfussin C–H (3 ... -
Kumada-Corriu coupling in synthesis of PAHs
Hovland, Lone; Røyland, Marita Finnesand (Master thesis, 2022)The thesis explores the Kumada-Corriu coupling reaction as a possible handle to further functionalize PAHs. The starting material used was different types of triflate bearing PAHs. An attempt at preparing phenanthren-9-yl ... -
Kumada-Corriu coupling in synthesis of PAHs
Hovland, Lone; Røyland, Marita Finnesand (Master thesis, 2022)The thesis explores the Kumada-Corriu coupling reaction as a possible handle to further functionalize PAHs. The starting material used was different types of triflate bearing PAHs. An attempt at preparing phenanthren-9-yl ... -
Metoder for å vurdere «grønnhet» og bærekraft til kjemiske prosesser
Bru, Håkon Olsen (Masteroppgave/UIS-TN-IKBM/2020;, Bachelor thesis, 2020-12)Formålet med denne oppgaven er å bevisstgjøre leseren om målemetoder av grønn kjemi samt deres viktighet for videre arbeid med grønn og bærekraftig kjemi. Oppgaven tar først for seg de mest relevante beregningsmetodene en ... -
MikroCT anvendelse for å evaluere porestruktur, porevolum og poredistribusjon i laksefôr.
Værland, Marit Cecilie (Masteroppgave/UIS-TN-IKBM/2019;, Master thesis, 2019-06-13)Pelleters fysiske kvalitet analyseres med typiske analysemetoder som vannstabilitet, fettlekkasje, hardhet, elastisitet, durabilitet, viskositet med mer, men disse analysene gir ikke tilstrekkelig informasjon om porestruktur ... -
Optimization of acid catalyzed transesterification of jatropha and rapeseed oil with 1-butanol
Bynes, Adrian N.; Eide, Ingvar; Jørgensen, Kåre Bredeli (Peer reviewed; Journal article, 2014-08)The acid catalyzed transesterification of rapeseed and jatropha oil with 1-butanol was studied by varying temperature, reaction time, butanol/triglyceride ratio and the amount of sulfuric acid. A full factorial design ... -
Oxidative synthesis of ortho-quinones from hydroxy-PAHs by stabilized formulation of 2-iodoxybenzoic acid (SIBX)
Tiruye, Hiwot Minwuyelet; Jørgensen, Kåre Bredeli (Peer reviewed; Journal article, 2022)Polycyclic aromatic phenols (PAPs or hydroxy-PAHs) are conveniently converted into their corresponding ortho-quinones using commercially available stabilized iodoxybenzoic acid (SIBX). SIBX provides a safer and commercially ... -
Regiospecific Photochemical Synthesis of Methylchrysenes
Bøhme, Thomas Andre; Egeland, Mari; Lorentzen, Marianne; Mady, Mohamed Fawzy Hamed Attia; Solbakk, Michelle F.; Sæbø, Krister Samsonsen; Jørgensen, Kåre Bredeli (Peer reviewed; Journal article, 2022-12)Methylated polycyclic aromatic hydrocarbons (PAHs) are suspected to be some of the toxic compounds in crude oil towards marine life and are needed as single compounds for environmental studies. 1-, 3- and 6-methylchrysene ... -
Regiospesific synthesis of dimethylphenanthrenes
Bøhme, Thomas Andre; Lorentzen, Marianne; Jørgensen, Kåre Bredeli (Peer reviewed; Journal article, 2017-05)The dimethylated phenanthrenes 2,3-dimethylphenanthrene (4a), 2,7-dimethylphenanthrene (4b), 2,6-dimethylphenanthrene (4c) and 1,7-dimethylphenanthrene (4d) have been prepared in gram-quantities by a short sequence of ... -
Relationships between Isomeric Metabolism and Regioselective Toxicity of Hydroxychrysenes in Embryos of Japanese Medaka (Oryzias latipes)
Tanabe, Philip; Pampanin, Daniela Maria; Tiruye, Hiwot Minwuyelet; Jørgensen, Kåre Bredeli; Hammond, Rachel; Gadepalli, Rama S.; Rimoldi, John M.; Schlenk, Daniel (Peer reviewed; Journal article, 2022)Oxygenated polycyclic aromatic hydrocarbons (oxy-PAHs) are ubiquitous contaminants that can be formed through oxidation of parent PAHs. Our previous studies found 2-hydroxychrysene (2-OHCHR) to be significantly more toxic ... -
Substituted Two- To Five-Ring Polycyclic Aromatic Compounds Are Potent Agonists of Atlantic Cod (Gadus morhua) Aryl Hydrocarbon Receptors Ahr1a and Ahr2a
Lille-Langøy, Roger; Jørgensen, Kåre Bredeli; Goksøyr, Anders; Pampanin, Daniela Maria; Sydnes, Magne Olav; Karlsen, Odd André (Peer reviewed; Journal article, 2021)Polycyclic aromatic hydrocarbons (PAHs) are among the most toxic and bioavailable components found in petroleum and represent a high risk to aquatic organisms. The aryl hydrocarbon receptor (Ahr) is a ligand-activated ... -
Synthesis of Phenacene−Helicene Hybrids by Directed Remote Metalation
Kancherla, Sindhu; Jørgensen, Kåre Bredeli (Peer reviewed; Journal article, 2020-08)Polycyclic aromatic hydrocarbons (PAHs) with six and seven rings were synthesized via directed metalation and cross-coupling of chrysenyl N,N-diethyl carboxamides with o-tolyl and methylnaphthalenyl derivatives. In the ... -
Total synthesis of tubastrine and 3-dehydroxy tubastrine by microwave-assisted cross-coupling reactions
Lorentzen, Marianne; Bayer, Annette; Sydnes, Magne Olav; Jørgensen, Kåre Bredeli (Journal article, 2015-10)The first syntheses of tubastrine and 3-dehydroxy tubastrine are described. The target compounds were prepared in four consecutive steps from commercially available starting materials. The central scaffold was formed by a ... -
Ultrasound-assisted synthesis of novel 1,2,3-triazoles coupled diaryl sulfone moieties by the CuAAC reaction, and biological evaluation of them as antioxidant and antimicrobial agents
Mady, Mohamed F.; Awad, Ghada E.A.; Jørgensen, Kåre Bredeli (Peer reviewed; Journal article, 2014-09)A series of 1,2,3-triazoles coupled diaryl sulfone containing compounds were synthesized by the copper-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC) reaction in benign solvents under ultrasound irradiation. In ...