Blar i Faculty of Science and Technology på tittel
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Meta-analysis of whole-exome sequencing data from two independent cohorts finds no evidence for rare variant enrichment in Parkinson disease associated loci
(Peer reviewed; Journal article, 2020-10)Parkinson disease (PD) is a complex neurodegenerative disorder influenced by both environmental and genetic factors. While genome wide association studies have identified several susceptibility loci, many causal variants ... -
Metabolic and Epithelial-to-Mesenchymal Transition Assesment of Colon Cancer Cell Lines
(Masteroppgave/UIS-TN-IKBM/2018;, Master thesis, 2018-06)Background: Cancer have varying dependency on oxidative phosphorylation and glycolysis, and cancer metastasis decreases the patient 5-year survival rate. Epithelial to mesenchymal transition (EMT) are demonstrated to ... -
Metabolic Assessment of Metformin Treatment in Colon Cancer Cells
(Masteroppgave/UIS-TN-IMN/2017;, Master thesis, 2017-06-01)Resistance against traditional chemotherapy is a challenge in the treatment of colorectal cancer (CRC). The use of metformin, a commonly prescribed biguanide anti-diabetic drug, has shown to correlate with cancer preventive ... -
Metabolic assessment of metformin treatment in the colon cancer cell line SW1116.
(Masteroppgave/UIS-TN-IMN/2017;, Master thesis, 2017-06-02)Cancers have different metabolic profiles, with varying dependency on glycolysis and mitochondrial oxidative phosphorylation (OXPHOS). The metabolic profile of cancer influences it sensitivity to treatments. Metformin, an ... -
Metabolic Cancer Therapy Using Graphene Drug Carriers: A study of biguanide drug effects in cellular and zebrafish larvae model systems
(PhD thesis UiS;, Doctoral thesis, 2021-11)Targeting cancer metabolism is an increasingly important strategy in the fight against cancer relapse. Metabolic drugs belonging to the biguanides family have gained attention in cancer treatment due to their ability to ... -
Metabolic Flexibility in Cancer Cells
(Bachelor thesis, 2022)Abstract Colorectal cancer is the third most occurring cancer type among both men and women in the United States. Even though cancer therapies have been revolutionarily improved over the decades, there is a high demand ... -
Metabolic flux analysis of 3D spheroids reveals significant differences in glucose metabolism from matched 2D cultures of colorectal cancer and pancreatic ductal adenocarcinoma cell lines
(Peer reviewed; Journal article, 2022-05)Background Most in vitro cancer cell experiments have been performed using 2D models. However, 3D spheroid cultures are increasingly favored for being more representative of in vivo tumor conditions. To overcome the ... -
Metabolic phenotype of leukemia cells as a determinant factor for the response to metformin in different glucose conditions
(Masteroppgave/UIS-TN-IKBM/2018;, Master thesis, 2018-06-15)Cancer cells are known to have highly dysregulated metabolic pathways and altered mitochondria which governs their limited capability of adaptation to nutritional growth conditions. Metabolic flexibility can be reduced by ... -
Metabolsk Fleksibilitet i Kreftceller
(Bachelor thesis, 2022)Kolorektalkreft er den tredje mest forekommende krefttypen blant både menn og kvinner i USA. Selv om kreftbehandlinger har blitt revolusjonerende forbedret gjennom flere tiår, er det stor etterspørsel etter mer effektive ... -
Metagenomic analysis of 16S rRNA genes for bacteria in the course of treatment of IBD patients at SUS
(Bachelor thesis, 2022)Keywords: Oxford Nanopore sequencing, 16S rRNA gene sequencing, IBD Since IBD is an increasing disease globally, it is vital to find out more about it. IBD causes many symptoms for the patient, including somatic symptoms ... -
Metal and elastomer matrix composite test method
(Masteroppgave/UIS-TN-IKM/2012;, Master thesis, 2012-06)The TDW Offshore Services’ SmartPlug(R) tool is designed to isolate a section of pipeline while it is pressurized. This enables pipeline repair without reducing pipeline pressure or bleeding down the entire pipeline system. ... -
Metal-organic frameworks for the recovery of critical metals for batteries
(Bachelor thesis, 2021)Lithium mining is a much sought after metal that is essential in many green technologies, especially battery technology. With the rising pressure on the planet’s climate a shift to greener alternatives is growing and with ... -
Metallic nanoparticles for enhanced heavy oil recovery: promises and challenges
(Journal article; Peer reviewed, 2015)With the increasing global energy demand, great attention has been focused on utilizing heavy oil and bitumen, which are potentially located ultra-deep underground and cannot be easily recovered. Numerous recovery approaches ... -
Meteorite impact crater crack extraction using artificial ants
(Masteroppgave/UIS-TN-IDE/2011;, Master thesis, 2011)This Master’s thesis deals with extracting crack information from images of rocks taken from a meteorite impact crater. By the use of artificial ants, and mathematical morphology, it becomes possible to detect the edges ... -
Metformin effekt på bukspyttkjertel kreftcellelinjene Panc-1 og MIA-Pa-Ca-2
(Bachelor thesis, 2021)This collaboration bachelor thesis focuses on cancer and how the drug metformin might be a future cancer treatment as it interrupt the cells metabolism by inhibition of complex I of the respiratory chain and numerous studies ... -
Metformin's Influence on Pancreatic Ductal Adenocarcinoma Metabolism and Chemotherapy Response
(Master thesis, 2023)Pancreatic cancer is a highly lethal disease with a 5-year survival rate of approximately 10%. One of the primary reasons for its lethality is the prevalence of chemoresistance. Several studies have found Oxidative ... -
Metformins effekt på bukspyttkjertel kreftcellelinjene Panc-1 og MIA-Pa-Ca-2
(Bachelor thesis, 2021)This collaboration bachelor thesis focuses on cancer and how the drug metformin might be a future cancer treatment as it interrupt the cells metabolism by inhibition of complex I of the respiratory chain and numerous studies ... -
Methane–propane hydrate formation and memory effect study with a reaction kinetics model
(Peer reviewed; Journal article, 2020-05)Although natural gas hydrates and hydrate exploration have been extensively studied for decades, the reaction kinetics and nucleation mechanism of hydrate formation is not fully understood. In its early stage, gas hydrate ... -
Method development for the extraction of pure intact mitochondria from beef heart and liver, and from HL-60 cultured cells.
(Masteroppgave/UIS-TN-IKBM/2019;, Master thesis, 2019-06)Mitochondria have an essential role in the preservation of life. Life persists as a result of structure and energy, and the mitochondria are key components of energy production. Mitochondrial dysfunction is considered a ... -
A method for assessing drilling fluid induced formation damage in permeable formations using ceramic discs
(Peer reviewed; Journal article, 2022)When drilling an oil and gas or geothermal well, the formation's ability to produce or flow may be reduced because of exposure to the drilling fluid during the drilling operation. To evaluate such formation damage, core ...