Blar i Publikasjoner fra CRIStin på emneord "VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762"
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Metformin treatment response is dependent on glucose growth conditions and metabolic phenotype in colorectal cancer cells
(Peer reviewed; Journal article, 2021-05)Cancer cells exhibit altered metabolism, a phenomenon described a century ago by Otto Warburg. However, metabolic drug targeting is considered an underutilized and poorly understood area of cancer therapy. Metformin, a ... -
MiR-18a and miR-18b are expressed in the stroma of oestrogen receptor alpha negative breast cancers
(Peer reviewed; Journal article, 2020-05)Background Previously, we have shown that miR-18a and miR-18b gene expression strongly correlates with high proliferation, oestrogen receptor -negativity (ER−), cytokeratin 5/6 positivity and basal-like features of breast ... -
miRNA normalization enables joint analysis of several datasets to increase sensitivity and to reveal novel miRNAs differentially expressed in breast cancer
(Peer reviewed; Journal article, 2021-02)Different miRNA profiling protocols and technologies introduce differences in the resulting quantitative expression profiles. These include differences in the presence (and measurability) of certain miRNAs. We present and ... -
Mitotic activity index and CD25+ lymphocytes predict risk of stage progression in non-muscle invasive bladder cancer
(Peer reviewed; Journal article, 2020-06)In urothelial cell type non-muscle invasive urinary bladder carcinoma, TNM stage and WHO grade are widely used to classify patients into low and high-risk groups for prognostic and therapeutic decision-making. However, ... -
The overriding role of surgery and tumor grade for long-term survival in patients with gastroenteropancreatic neuroendocrine neoplasms: A population-based cohort study
(Peer reviewed; Journal article, 2021-06)Background Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) comprise a heterogeneous disease group. Factors that affect long-term survival remain uncertain. Complete population-representative cohorts with long-term ... -
Patterns of Care and Survival in Cancer Patients with Brain Metastases Receiving Immune Checkpoint Inhibitors
(Peer reviewed; Journal article, 2023)Introduction: Immune checkpoint inhibitors (ICIs) have become a mainstay of treatment for different cancer types. The purpose of this study was to evaluate patterns of care and overall survival (OS) after diagnosis of brain ... -
Platelet microparticles protect acute myelogenous leukemia cells against daunorubicin-induced apoptosis
(Peer reviewed; Journal article, 2021-04)The role of platelets in cancer development and progression is increasingly evident, and several platelet–cancer interactions have been discovered, including the uptake of platelet microparticles (PMPs) by cancer cells. ... -
Prediction of death rates for cardiovascular diseases and cancers
(Peer reviewed; Journal article, 2023)Background To estimate cardiovascular and cancer death rates by regions and time periods. Design Novel statistical methods were used to analyze clinical surveillance data. Methods A multicenter, population-based ... -
Prenatal BRCA1 epimutations contribute significantly to triple-negative breast cancer development
(Peer reviewed; Journal article, 2023)Background Normal cell BRCA1 epimutations have been associated with increased risk of triple-negative breast cancer (TNBC). However, the fraction of TNBCs that may have BRCA1 epimutations as their underlying cause is ... -
Prevalence of PD‑L1 expression is associated with EMAST, density of peritumoral T‑cells and recurrence‑free survival in operable non‑metastatic colorectal cancer
(Peer reviewed; Journal article, 2020-08)Introduction Microsatellite instability (MSI) predict response to anti-PD1 immunotherapy in colorectal cancer (CRC). CRCs with MSI have higher infiltration of immune cells related to a better survival. Elevated Microsatellite ... -
Prognostic value and reproducibility of different microscopic characteristics in the WHO grading systems for pTa and pT1 urinary bladder urothelial carcinomas
(Peer reviewed; Journal article, 2019-08)Background: European treatment guidelines for pTa and pT1 urinary bladder urothelial carcinoma depend highly on stage and WHO-grade. Both the WHO73 and the WHO04 grading systems show some intra- and interobserver variability. ... -
Prostate Biopsies Can Be Omitted in Most Patients with a Positive Stockholm3 Test and Negative Prostate Magnetic Resonance Imaging
(Peer reviewed; Journal article, 2023-10)Background Magnetic resonance imaging (MRI) combined with the Stockholm3 test can be used to inform biopsy decision-making in patients with a suspicion of prostate cancer. Objective To determine the consequence of ... -
Refined TNM-staging for pancreatic adenocarcinoma – Real progress or much ado about nothing?
(Peer reviewed; Journal article, 2020-08)In order to provide optimal cancer care and prognostication, it is necessary to stage the disease. The 8th edition of the TNM-staging for exocrine pancreatic ductal adenocarcinoma (PDAC) system has refined size-based ... -
Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients
(Journal article; Peer reviewed, 2017)Background Controversies exist as to whether the genetic polymorphisms of the enzymes responsible for the metabolism of tamoxifen can predict breast cancer outcome in patients using adjuvant tamoxifen. Direct measurement ... -
Stakeholders’ Perspectives on eHealth Support in Colorectal Cancer Survivorship: Qualitative Interview Study
(Peer reviewed; Journal article, 2021-02)Background: eHealth interventions may represent the way forward in following up patients with colorectal cancer (CRC) after hospital discharge to support them in coping with the illness, strengthen their self-management, ... -
T1 Substaging of Nonmuscle Invasive Bladder Cancer is Associated with bacillus Calmette-Guérin Failure and Improves Patient Stratification at Diagnosis
(Peer reviewed; Journal article, 2021-03)Purpose: Currently, markers are lacking that can identify patients with high risk nonmuscle invasive bladder cancer who will fail bacillus Calmette-Guérin treatment. Therefore, we evaluated the prognostic value of T1 ... -
A U‑net based approach to epidermal tissue segmentation in whole slide histopathological images
(Peer reviewed; Journal article, 2019-06)Malignant melanoma is a severe and aggressive type of skin cancer, with a rapid decrease in survival rate if not diagnosed and treated at an early stage. Histopathological examination of hematoxylin and eosin stained tissue ...