dc.contributor.author | Berg, Åse | |
dc.contributor.author | Patel, Sam | |
dc.contributor.author | Gonca, Miguel | |
dc.contributor.author | Catarina, David | |
dc.contributor.author | Otterdal, Kari | |
dc.contributor.author | Ueland, Thor | |
dc.contributor.author | Dalen, Ingvild | |
dc.contributor.author | Kvaløy, Jan Terje | |
dc.contributor.author | Mollnes, Tom Eirik | |
dc.contributor.author | Aukrust, Pål | |
dc.contributor.author | Langeland, Nina | |
dc.date.accessioned | 2015-03-03T16:18:02Z | |
dc.date.accessioned | 2015-11-26T10:22:10Z | |
dc.date.available | 2015-03-03T16:18:02Z | |
dc.date.available | 2015-11-26T10:22:10Z | |
dc.date.issued | 2014-12 | |
dc.identifier.citation | Berg A, Patel S, Gonca M, David C, Otterdal K, et al. (2014) Cytokine network in adults with falciparum malaria and HIV-1: Increased IL-8 and IP-10 levels are associated with disease severity. PLoS ONE 9(12): e114480. doi:10.1371/ journal.pone.0114480 | nb_NO |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/11250/2365831 | |
dc.description | The article was originally published in PloS One in 2014. Copyright:
2014 Berg et al. This is an open-
access article distributed under the terms of the
Creative Commons Attribution License, which
permits unrestricted use, distribution, and reproduction in any medium, provided the original author
and source are credited | nb_NO |
dc.description.abstract | Background:
Co-infection with malaria and HIV increases the severity and
mortality of both diseases, but the cytokine responses related to this co-infection
are only partially characterised. The aim of this study was to explore cytokine
responses in relation to severity and mortality in malaria patients with and without
HIV co-infection.
Methods:
This was a prospective cross-sectional study. Clinical data and blood
samples were collected from adults in Mozambique. Plasma was analysed for 21
classical pro- and anti-inflammatory cytokines, including interleukins, interferons,
and chemokines.
Results:
We included 212 in-patients with fever and/or suspected malaria and 56
healthy controls. Falciparum malaria was diagnosed in 131 patients, of whom 70
were co-infected with HIV-1. The malaria patients had marked increases in their
cytokine responses compared with the healthy controls. Some of these changes,
particularly interleukin 8 (IL-8) and interferon-
y
-inducing protein 10 (IP-10) were
strongly associated with falciparum malaria and disease severity. Both these
chemokines were markedly increased in patients with falciparum malaria as
compared with healthy controls, and raised levels of IL-8 and IP-10 were associated with increased disease severity, even after adjusting for relevant
confounders. For IL-8, particularly high levels were found in malaria patients that
were co-infected with HIV and in those who died during hospitalization.
Interpretations:
Our findings underscore the complex role of inflammation during
infection with
P. falciparum,
and suggest a potential pathogenic role for IL-8 and IP-10. However, the correlations do not necessarily mean any causal relationship, and
further both clinical and mechanistic research is necessary to elucidate the role of
cytokines in pathogenesis and protection during falciparum malaria. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Public Library of Science (PLoS) | nb_NO |
dc.rights | Navngivelse 3.0 Norge | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/no/ | * |
dc.subject | malaria | nb_NO |
dc.subject | Mozambique | nb_NO |
dc.subject | HIV | nb_NO |
dc.title | Cytokine network in adults with falciparum malaria and HIV-1: increased IL-8 and IP-10 levels are associated with disease severity | nb_NO |
dc.type | Journal article | nb_NO |
dc.date.updated | 2015-03-03T16:18:02Z | |
dc.subject.nsi | VDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Infeksjonsmedisin: 776 | nb_NO |
dc.subject.nsi | VDP::Midical sciences: 700::Clinical medical sciences: 750::Communicable diseases: 776 | nb_NO |
dc.subject.nsi | VDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Tropemedisin: 761 | nb_NO |
dc.subject.nsi | VDP::Midical sciences: 700::Clinical medical sciences: 750::Tropical medicine: 761 | nb_NO |
dc.source.volume | 9 | nb_NO |
dc.source.journal | PLoS One | nb_NO |
dc.source.issue | 12 | nb_NO |
dc.identifier.doi | 10.1371/journal.pone.0114480 | |
dc.identifier.cristin | 1192330 | |