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dc.contributor.authorBreitve, Monica Haraldseid
dc.contributor.authorChwiszczuk, Luiza
dc.contributor.authorHynninen, Kia Minna
dc.contributor.authorRongve, Arvid
dc.contributor.authorBrønnick, Kolbjørn S
dc.contributor.authorJanvin, Carmen Cristea
dc.contributor.authorAarsland, Dag
dc.identifier.citationBreitve, M.H. et al. A systematic review of cognitive decline in dementia with Lewy bodies versus Alzheimer’s disease. Alzheimer's Research & Therapy 2014, 6:53nb_NO
dc.descriptionThe article was originally published in Alzheimer's Research & Therapy; and distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.nb_NO
dc.description.abstractIntroduction: The aim of this review was to investigate whether there is a faster cognitive decline in dementia with Lewy bodies (DLB) than in Alzheimer’s disease (AD) over time. Methods: PsycINFO and Medline were searched from 1946 to February 2013. A quality rating from 1 to 15 (best) was applied to the included studies. A quantitative meta-analysis was done on studies with mini mental state examination (MMSE) as the outcome measure. Results: A total of 18 studies were included. Of these, six (36%) reported significant differences in the rate of cognitive decline. Three studies reported a faster cognitive decline on MMSE in patients with mixed DLB and AD compared to pure forms, whereas two studies reported a faster decline on delayed recall and recognition in AD and one in DLB on verbal fluency. Mean quality scores for studies that did or did not differ were not significantly different. Six studies reported MMSE scores and were included in the meta-analysis, which showed no significant difference in annual decline on MMSE between DLB (mean 3.4) and AD (mean 3.3). Conclusions: Our findings do not support the hypothesis of a faster rate of cognitive decline in DLB compared to AD. Future studies should apply recent diagnostic criteria, as well as extensive diagnostic evaluation and ideally autopsy diagnosis. Studies with large enough samples, detailed cognitive tests, at least two years follow up and multivariate statistical analysis are also needed.nb_NO
dc.publisherBioMed Centralnb_NO
dc.rightsNavngivelse 3.0 Norge*
dc.subjectdementia with Lewy bodiesnb_NO
dc.subjectdemens med Lewy-legemer
dc.titleA systematic review of cognitive decline in dementia with Lewy bodies versus Alzheimer’s diseasenb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewed
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Geriatri: 778nb_NO
dc.subject.nsiVDP::Midical sciences: 700::Clinical medical sciences: 750::Geriatrics: 778nb_NO
dc.subject.nsiVDP::Samfunnsvitenskap: 200::Psykologi: 260::Kognitiv psykologi: 267nb_NO
dc.subject.nsiVDP::Social sciences: 200::Psychology: 260::Cognitive psychology: 267nb_NO
dc.source.journalAlzheimer's Research & Therapynb_NO

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