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dc.contributor.authorVeen, Torhild
dc.contributor.authorStormark, Kjartan
dc.contributor.authorNedrebø, Bjørn Steinar Olden
dc.contributor.authorBerg, Marianne
dc.contributor.authorSøreide, Jon Arne
dc.contributor.authorKørner, Hartwig
dc.contributor.authorSøreide, Kjetil
dc.date.accessioned2015-11-10T12:08:10Z
dc.date.accessioned2016-03-10T09:32:16Z
dc.date.available2015-11-10T12:08:10Z
dc.date.available2016-03-10T09:32:16Z
dc.date.issued2015-04
dc.identifier.citationVeen, T. et al. (2015) Long-term follow-up and survivorship after completing systematic surveillance in stage I–III colorectal cancer: who is still at risk? Journal of Gastrointestinal Cancer, 46(3):259-266nb_NO
dc.identifier.issn1941-6636
dc.identifier.urihttp://hdl.handle.net/11250/2381959
dc.descriptionThis article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licen ses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.nb_NO
dc.description.abstractPurpose In patients with a high life expectancy at the time of surgery for colorectal cancer (CRC), the long-term outcome may be influenced by factors other than their cancer. We aimed to investigate the long-term outcome and cause of death beyond a 5-year surveillance programme. Methods We evaluated the overall survival (OS) and cancer- specific survival (CSS) of a population-based cohort of stage I – III CRC patients <75 years old who completed a systematic surveillance programme. Results In total, 161 patients <75 years old, 111 (69 %) of whom were node negative (pN0), were included. The median follow-up time was 12.1 years. The OS was 54 % at 15 years and differed significantly between the pN0 and pN+ patients (65 vs. 30 %; P <0.001); CSS (72 %) also differed between the pN0 and pN+ patients (85 vs. 44 %; P <0.001). For the 5-year survivors (n=119), 14 (12 %) died of CRC during additional long-term follow-up (7 each for pN0 and pN+), and 6 patients (5 %; all pN0) died of other cancers. Patients aged <65 years exhibited better long-term survival (81 %), but most of the deaths were due to CRC (10/12 deaths). Only two of the 14 cancer-related deaths involved microsatellite instable (MSI) CRC. Females exhibited better OS and CSS beyond 5 years of surveillance. Conclusions The long-term survival beyond 5-year survivor- ship for stage I – III CRC is very good. Nonetheless, cancer- related deaths are encountered in one-third of patients and occur most frequently in patients who are <65 years old at disease onset — pointing to a still persistent risk several years after surgerynb_NO
dc.language.isoengnb_NO
dc.publisherSpringernb_NO
dc.rightsNavngivelse 3.0 Norge*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/no/*
dc.subjectoncologynb_NO
dc.subjectonkologinb_NO
dc.subjectkreftnb_NO
dc.subjectforventet levetidnb_NO
dc.subjectsurvivalnb_NO
dc.subjectoverlevelsesratenb_NO
dc.subjectcolorectal cancernb_NO
dc.subjectmicrosatellite instabilitynb_NO
dc.titleLong-term follow-up and survivorship after completing systematic surveillance in stage I–III colorectal cancer: who is still at risk?nb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.date.updated2015-11-10T12:08:10Z
dc.rights.holderCopyright The Author(s) 2015.nb_NO
dc.subject.nsiVDP::Medical disciplines: 700::Clinical medical disciplines: 750nb_NO
dc.source.pagenumber259-266nb_NO
dc.source.volume46nb_NO
dc.source.journalJournal of Gastrointestinal Cancernb_NO
dc.source.issue3nb_NO
dc.identifier.doi10.1007/s12029-015-9723-2
dc.identifier.cristin1253602


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Navngivelse 3.0 Norge
Except where otherwise noted, this item's license is described as Navngivelse 3.0 Norge