dc.contributor.author | Veen, Torhild | |
dc.contributor.author | Stormark, Kjartan | |
dc.contributor.author | Nedrebø, Bjørn Steinar Olden | |
dc.contributor.author | Berg, Marianne | |
dc.contributor.author | Søreide, Jon Arne | |
dc.contributor.author | Kørner, Hartwig | |
dc.contributor.author | Søreide, Kjetil | |
dc.date.accessioned | 2015-11-10T12:08:10Z | |
dc.date.accessioned | 2016-03-10T09:32:16Z | |
dc.date.available | 2015-11-10T12:08:10Z | |
dc.date.available | 2016-03-10T09:32:16Z | |
dc.date.issued | 2015-04 | |
dc.identifier.citation | Veen, T. et al. (2015) Long-term follow-up and survivorship after completing systematic surveillance in stage I–III colorectal cancer: who is still at risk? Journal of Gastrointestinal Cancer, 46(3):259-266 | nb_NO |
dc.identifier.issn | 1941-6636 | |
dc.identifier.uri | http://hdl.handle.net/11250/2381959 | |
dc.description | This article is published with open access at Springerlink.com. This article is distributed under the terms of the
Creative Commons Attribution 4.0 International License
(http://creativecommons.org/licen
ses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the
source, provide a link to the Creative Commons license, and
indicate if changes were made. | nb_NO |
dc.description.abstract | Purpose
In patients with a high life expectancy at the time of
surgery for colorectal cancer (CRC), the long-term outcome
may be influenced by factors other than their cancer. We
aimed to investigate the long-term outcome and cause of death
beyond a 5-year surveillance programme.
Methods
We evaluated the overall survival (OS) and cancer-
specific survival (CSS) of a population-based cohort of stage
I – III CRC patients <75 years old who completed a systematic
surveillance programme.
Results
In total, 161 patients <75 years old, 111 (69 %) of
whom were node negative (pN0), were included. The median
follow-up time was 12.1 years. The OS was 54 % at 15 years
and differed significantly between the pN0 and pN+ patients
(65 vs. 30 %;
P
<0.001); CSS (72 %) also differed between the
pN0 and pN+ patients (85 vs. 44 %;
P
<0.001). For the 5-year
survivors (n=119), 14 (12 %) died of CRC during additional
long-term follow-up (7 each for pN0 and pN+), and 6 patients
(5 %; all pN0) died of other cancers. Patients aged <65 years
exhibited better long-term survival (81 %), but most of the
deaths were due to CRC (10/12 deaths). Only two of the 14 cancer-related deaths involved microsatellite instable (MSI)
CRC. Females exhibited better OS and CSS beyond 5 years
of surveillance.
Conclusions
The long-term survival beyond 5-year survivor-
ship for stage I – III CRC is very good. Nonetheless, cancer-
related deaths are encountered in one-third of patients and
occur most frequently in patients who are <65 years old at
disease onset — pointing to a still persistent risk several years
after surgery | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Springer | nb_NO |
dc.rights | Navngivelse 3.0 Norge | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/no/ | * |
dc.subject | oncology | nb_NO |
dc.subject | onkologi | nb_NO |
dc.subject | kreft | nb_NO |
dc.subject | forventet levetid | nb_NO |
dc.subject | survival | nb_NO |
dc.subject | overlevelsesrate | nb_NO |
dc.subject | colorectal cancer | nb_NO |
dc.subject | microsatellite instability | nb_NO |
dc.title | Long-term follow-up and survivorship after completing systematic surveillance in stage I–III colorectal cancer: who is still at risk? | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.date.updated | 2015-11-10T12:08:10Z | |
dc.rights.holder | Copyright The Author(s) 2015. | nb_NO |
dc.subject.nsi | VDP::Medical disciplines: 700::Clinical medical disciplines: 750 | nb_NO |
dc.source.pagenumber | 259-266 | nb_NO |
dc.source.volume | 46 | nb_NO |
dc.source.journal | Journal of Gastrointestinal Cancer | nb_NO |
dc.source.issue | 3 | nb_NO |
dc.identifier.doi | 10.1007/s12029-015-9723-2 | |
dc.identifier.cristin | 1253602 | |