dc.contributor.author | Watson, Martin Matthew Christian | |
dc.contributor.author | Lea, Dordi | |
dc.contributor.author | Rewcastle, Emma | |
dc.contributor.author | Hagland, Hanne Røland | |
dc.contributor.author | Søreide, Kjetil | |
dc.date.accessioned | 2017-05-18T08:31:11Z | |
dc.date.available | 2017-05-18T08:31:11Z | |
dc.date.created | 2017-01-16T22:01:01Z | |
dc.date.issued | 2016-02 | |
dc.identifier.citation | Watson, M.M. (2016) Elevated microsatellite alterations at selected tetranucleotides in early-stage colorectal cancers with and without high-frequency microsatellite instability: same, same but different? Cancer Medicine. 5(7), 1580-1587. | nb_NO |
dc.identifier.issn | 2045-7634 | |
dc.identifier.uri | http://hdl.handle.net/11250/2442715 | |
dc.description.abstract | Microsatellite instability (MSI) is associated with better prognosis in colorectal cancer (CRC). Elevated microsatellite alterations at selected tetranucleotides (EMAST) is a less-understood form of MSI. Here, we aim to investigate the role of EMAST in CRC±MSI related to clinical and tumor-specific characteristics. A consecutive, population-based series of stage I–III colorectal cancers were investigated for MSI and EMAST using PCR primers for 10 microsatellite markers. Of 151 patients included, 33 (21.8%) had MSI and 35 (23.2%) were EMAST+, with an overlap of 77% for positivity, (odds ratio [OR] 61; P < 0.001), and 95% for both markers being negative. EMAST was more prevalent in colon versus rectum (86% vs. 14%, P = 0.004). EMAST+ cancers were significantly more frequent in proximal colon (77 vs. 23%, P = 0.004), had advanced t-stage (T3–4 vs. T1–2 in 94% vs. 6%, respectively; P = 0.008), were larger (≥5 cm vs. <5 cm in 63% and 37%, respectively; P = 0.022) and had poorly differentiated tumor grade (71 vs. 29%, P < 0.01). Furthermore, EMAST+ tumors had a higher median number of harvested lymph nodes than EMAST− (11 vs. 9 nodes; P = 0.03). No significant association was found between EMAST status and age, gender, presence of distant metastases or metastatic lymph nodes, and overall survival. A nonsignificant difference toward worse survival in node-negative colon cancers needs confirmation in larger cohorts. EMAST+ cancers overlap and share features with MSI+ in CRC. Overall, survival was not influenced by the presence of EMAST, but may be of importance in subgroups such as node-negative disease of the colon. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | John Wiley & Sons Ltd. | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.subject | colorectal cancer | nb_NO |
dc.subject | mage- og tarmkreft | nb_NO |
dc.subject | levated microsatellite alterations | nb_NO |
dc.subject | microsatellite instability | nb_NO |
dc.subject | node status | nb_NO |
dc.subject | survival | nb_NO |
dc.title | Elevated microsatellite alterations at selected tetranucleotides in early-stage colorectal cancers with and without high-frequency microsatellite instability: same, same but different? | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | |
dc.rights.holder | © The authors | nb_NO |
dc.subject.nsi | VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762 | nb_NO |
dc.source.pagenumber | 1580-1587 | nb_NO |
dc.source.volume | 5 | nb_NO |
dc.source.journal | Cancer Medicine | nb_NO |
dc.source.issue | 7 | nb_NO |
dc.identifier.doi | 10.1002/cam4.709 | |
dc.identifier.cristin | 1429089 | |
cristin.unitcode | 217,8,2,0 | |
cristin.unitname | Institutt for matematikk og naturvitenskap | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |