Blar i Faculty of Health Sciences på forfatter "Lea, Dordi"
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Elevated microsatellite alterations at selected tetranucleotides (EMAST) is not attributed to MSH3 loss in stage I-III colon cancer: An automated, digitalized assessment by immunohistochemistry of whole slides and hot spots
Watson, Martin; Lea, Dordi; Hagland, Hanne Røland; Søreide, Kjetil (Journal article; Peer reviewed, 2019-12)INTRODUCTION: EMAST is a poorly understood form of microsatellite instability (MSI) in colorectal cancer (CRC) for which loss of MSH3 has been proposed as the underlying mechanism, based on experimental studies. We aimed ... -
The overriding role of surgery and tumor grade for long-term survival in patients with gastroenteropancreatic neuroendocrine neoplasms: A population-based cohort study
Søreide, Jon Arne; Kvaløy, Jan Terje; Lea, Dordi; Sandvik, Oddvar M.; Al-Saiddi, Mohammed; Haslerud, Torjan M.; Garresori, Herish; Karlsen, Lars Normann; Gudlaugsson, Einar; Søreide, Kjetil (Peer reviewed; Journal article, 2021-06)Background Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) comprise a heterogeneous disease group. Factors that affect long-term survival remain uncertain. Complete population-representative cohorts with long-term ... -
Prevalence of PD‑L1 expression is associated with EMAST, density of peritumoral T‑cells and recurrence‑free survival in operable non‑metastatic colorectal cancer
Watson, Martin Matthew Christian; Lea, Dordi; Gudlaugsson, Einar; Skaland, Ivar; Hagland, Hanne Røland; Søreide, Kjetil (Peer reviewed; Journal article, 2020-08)Introduction Microsatellite instability (MSI) predict response to anti-PD1 immunotherapy in colorectal cancer (CRC). CRCs with MSI have higher infiltration of immune cells related to a better survival. Elevated Microsatellite ...