dc.contributor.author | Lorentzen, Marianne | |
dc.contributor.author | Bayer, Annette | |
dc.contributor.author | Sydnes, Magne Olav | |
dc.contributor.author | Jørgensen, Kåre Bredeli | |
dc.date.accessioned | 2016-09-13T11:45:32Z | |
dc.date.accessioned | 2021-06-01T06:36:08Z | |
dc.date.available | 2016-09-13T11:45:32Z | |
dc.date.available | 2021-06-01T06:36:08Z | |
dc.date.issued | 2015-10 | |
dc.identifier.citation | Lorentzen. M., Bayer, A., Sydnes, M.O., Jørgensen, K.B. (2015) Total synthesis of tubastrine and 3-dehydroxy tubastrine by microwave-assisted cross-coupling reactions. Tetrahedron, 71(43), 8278-8284 | en_US |
dc.identifier.issn | 1464-5416 | |
dc.identifier.uri | https://hdl.handle.net/11250/2757125 | |
dc.description.abstract | The first syntheses of tubastrine and 3-dehydroxy tubastrine are described. The target compounds were prepared in four consecutive steps from commercially available starting materials. The central scaffold was formed by a microwave-assisted C–N cross-coupling reaction between 1,3-bis(tert-butoxycarbonyl)-guanidine and (E)-((4-(2-iodovinyl)-1,2-phenylene)bis(oxy))bis(tert-butyldimethylsilane) and (E)-tert-butyl(4-(2-iodovinyl)phenoxy)–dimethylsilane, respectively. The aryl vinyl iodides were obtained by a Hunsdiecker–Borodin-type reaction of aryl acrylic acids, which were easily available from trans-caffeic acid or trans-p-coumaric acid. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Ltd. | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.subject | kjemi | en_US |
dc.title | Total synthesis of tubastrine and 3-dehydroxy tubastrine by microwave-assisted cross-coupling reactions | en_US |
dc.type | Journal article | en_US |
dc.date.updated | 2016-09-13T11:45:32Z | |
dc.description.version | acceptedVersion | en_US |
dc.rights.holder | © 2015 Elsevier Ltd. All rights reserved. | en_US |
dc.subject.nsi | VDP::Matematikk og Naturvitenskap: 400::Kjemi: 440 | en_US |
dc.source.volume | 71 | en_US |
dc.source.issue | 43 | en_US |
dc.identifier.doi | 10.1016/j.tet.2015.09.003 | |
dc.identifier.cristin | 1262112 | |
dc.relation.project | Norges forskningsråd: 224790 | en_US |