Duration of elevated heart rate Is an important predictor of exercise-induced troponin elevation
Bjørkavoll-Bergseth, Magnus; Kleiven, Øyunn; Auestad, Bjørn Henrik; Eftestøl, Trygve Christian; Oskal, Kay Raymond; Nygård, Martin; Skadberg, Øyvind; Aakre, Kristin Moberg; Melberg, Tor Harald; Gjesdal, Knut; Ørn, Stein
Peer reviewed, Journal article
Published version
Date
2020Metadata
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Original version
Bjørkavoll‐Bergseth, M., Kleiven, Ø., Auestad, B., Eftestøl, T., Oskal, K., Nygård, M., ... & Ørn, S. (2020). Duration of elevated heart rate is an important predictor of exercise‐induced troponin elevation. Journal of the American heart association, 9(4), e014408. 10.1161/JAHA.119.014408Abstract
Background
The precise mechanisms causing cardiac troponin (cTn) increase after exercise remain to be determined. The aim of this study was to investigate the impact of heart rate (HR) on exercise‐induced cTn increase by using sports watch data from a large bicycle competition.
Methods and Results
Participants were recruited from NEEDED (North Sea Race Endurance Exercise Study). All completed a 91‐km recreational mountain bike race (North Sea Race). Clinical status, ECG, blood pressure, and blood samples were obtained 24 hours before and 3 and 24 hours after the race. Participants (n=177) were, on average, 44 years old; 31 (18%) were women. Both cTnI and cTnT increased in all individuals, reaching the highest level (of the 3 time points assessed) at 3 hours after the race (P<0.001). In multiple regression models, the duration of exercise with an HR >150 beats per minute was a significant predictor of both cTnI and cTnT, at both 3 and 24 hours after exercise. Neither mean HR nor mean HR in percentage of maximum HR was a significant predictor of the cTn response at 3 and 24 hours after exercise.
Conclusions
The duration of elevated HR is an important predictor of physiological exercise‐induced cTn elevation.