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dc.contributor.authorGordon, Amy R.
dc.contributor.authorLundström, Johan N.
dc.contributor.authorKimball, Bruce A.
dc.contributor.authorKarshikoff, Bianka
dc.contributor.authorSorjonen, Kimmo
dc.contributor.authorAxelsson, John
dc.contributor.authorLekander, Mats
dc.contributor.authorOlsson, Mats J.
dc.identifier.citationGordon, A. R., Lundström, J. N., Kimball, B. A., Karshikoff, B., Sorjonen, K., Axelsson, J., ... & Olsson, M. J. (2023). Human scent as a first-line defense against disease. Scientific Reports, 13(1), 16709.en_US
dc.description.abstractIndividuals may have a different body odor, when they are sick compared to healthy. In the non-human animal literature, olfactory cues have been shown to predict avoidance of sick individuals. We tested whether the mere experimental activation of the innate immune system in healthy human individuals can make an individuals’ body odor be perceived as more aversive (intense, unpleasant, and disgusting). Following an endotoxin injection (lipopolysaccharide; 0.6 ng/kg) that creates a transient systemic inflammation, individuals smelled more unpleasant compared to a placebo group (saline injection). Behavioral and chemical analyses of the body odor samples suggest that the volatile components of samples from “sick” individuals changed qualitatively rather than quantitatively. Our findings support the hypothesis that odor cues of inflammation in axillary sweat are detectable just a few hours after experimental activation of the innate immune system. As such, they may trigger behavioral avoidance, hence constituting a first line of defense against pathogens of infected conspecifics.en_US
dc.publisherSpringer Natureen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleHuman scent as a first-line defense against diseaseen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.rights.holderThe authorsen_US
dc.subject.nsiVDP::Medisinske Fag: 700en_US
dc.subject.nsiVDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470en_US
dc.source.journalScientific Reportsen_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal