• Automatic diagnostic tool for predicting cancer grade in bladder cancer patients using deep learning 

      Wetteland, Rune; Engan, Kjersti; Eftestøl, Trygve Christian; Kvikstad, Vebjørn; Janssen, Emiel; Tøssebro, Erlend; Lillesand, Melinda (Peer reviewed; Journal article, 2021-08)
      The most common type of bladder cancer is urothelial carcinoma, which is among the cancer types with the highest recurrence rate and lifetime treatment cost per patient. Diagnosed patients are stratified into risk groups, ...
    • Better prognostic markers for nonmuscle invasive papillary urothelial carcinomas 

      Kvikstad, Vebjørn (PhD thesis UiS;, Doctoral thesis, 2022-04)
      Bladder cancer is a common type of cancer, especially among men in developed countries. Most cancers in the urinary bladder are papillary urothelial carcinomas. They are characterized by a high recurrence frequency (up to ...
    • Combined HER3-EGFR score in triple-negative breast cancer provides prognostic and predictive significance superior to individual biomarkers 

      Ogden, Angela; Bhattarai, Shristi; Sahoo, Bikram; Mongan, Nigel P.; Alsaleem, Mansour; Green, Andrew R.; Aleskandarany, Mohammed; Ellis, Ian O.; Pattni, Sonal; Li, Xiaoxian Bill; Moreno, Carlos S.; Krishnamurti, Uma; Janssen, Emiel; Jonsdottir, Kristin; Rakha, Emad; Rida, Padmashree; Aneja, Ritu (Peer reviewed; Journal article, 2020)
      Epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 3 (HER3) have been investigated as triple-negative breast cancer (TNBC) biomarkers. Reduced EGFR levels can be compensated by increases in ...
    • Detection and localization of melanoma skin cancer in histopathological whole slide images 

      Kanwal, Neel; Amundsen, Roger; Hardardottir, Helga; Tomasetti, Luca; Undersrud, Erling Sandøy; Janssen, Emiel; Engan, Kjersti (European Signal Processing Conference;, Chapter; Conference object, 2023)
      If melanoma is diagnosed and treated in its early stages can increase the survival rate. A projected increase in skin cancer incidents and a shortage of dermatopathologists have emphasized the need for computational pathology ...
    • Digital Image Analysis of Ki-67 Stained Tissue Microarrays and Recurrence in Tamoxifen-Treated Breast Cancer Patients 

      Egeland, Nina Gran; Jonsdottir, Kristin; Lauridsen, Kristina Lystlund; Skaland, Ivar; Hjorth, Cathrine F.; Gudlaugsson, Einar; Hamilton-Dutoit, Stephen Jacques; Lash, Timothy L.; Cronin-Fenton, Deidre; Janssen, Emiel (Peer reviewed; Journal article, 2020-07)
      Purpose: The proliferation marker Ki-67 has been used as a prognostic marker to separate low- and high-risk breast cancer subtypes and guide treatment decisions for adjuvant chemotherapy. The association of Ki-67 with ...
    • Discovery and Validation of Biomarkers in Breast Cancer 

      Egeland, Nina Gran (PhD thesis UiS;546, Doctoral thesis, 2020-09)
      Worldwide, breast cancer is the most common malignancy among women, and although treatment and prognosis have improved substantially over the last decades, for some patients the risk of recurrence remains for several years ...
    • Distinct Gene Expression Profiles of Matched Primary and Metastatic Triple-Negative Breast Cancers 

      Kaur, Jaspreet; Chandrashekar, Darshan S.; Varga, Zsuzsanna; Sobottka, Bettina; Janssen, Emiel; Kowalski, Jeanne; Kiraz, Umay; Varambally, Sooryanarayana; Aneja, Ritu (Peer reviewed; Journal article, 2022)
      Background: Although triple-negative breast cancer (TNBC) is associated with an increased risk of recurrence and metastasis, the molecular mechanisms underlying metastasis in TNBC remain unknown. To identify transcriptional ...
    • Effects of replacing PSA with Stockholm3 for diagnosis of clinically significant prostate cance in a health care system – the Stavanger Experience 

      Viste, Eirik; Vinje, Cathrine Alvær; Lid, Torgeir Gilje; Skeie, Svein; Evjen-Olsen, Øystein; Nordström, Tobias; Thorsen, Olav; Gilje, Bjørnar; Janssen, Emiel; Kjosavik, Svein Reidar (Peer reviewed; Journal article, 2020-08)
      Objective To describe early experience of replacing PSA with Stockholm3 for detection of prostate cancer in primary care. Design and methods Longitudinal observations, comparing outcome measures before and after the ...
    • Estimating diagnostic uncertainty in artificial intelligence assisted pathology using conformal prediction 

      Olsson, Henrik; Kartasalo, Kimmo; Mulliqi, Nita; Capuccini, Marco; Ruusuvuori, Pekka; Samaratunga, Hemamali; Delahunt, Brett; Lindskog, Cecilia; Janssen, Emiel; Blilie, Anders; Egevad, Lars; Spjuth, Ola; Eklund, Martin (Peer reviewed; Journal article, 2022)
      Unreliable predictions can occur when an artificial intelligence (AI) system is presented with data it has not been exposed to during training. We demonstrate the use of conformal prediction to detect unreliable predictions, ...
    • High-Grade Cervical Intraepithelial Neoplasia (CIN) Associates with Increased Proliferation and Attenuated Immune Signaling 

      Øvestad, Irene Tveiterås; Engesæter, Birgit Øvstebø; Halle, Mari Kyllesø; Akbari, Saleha; Bicskei, Beatrix; Lapin, Morten; Austdal, Marie; Janssen, Emiel; Krakstad, Camilla; Lillesand, Melinda; Nordhus, Marit; Munk, Ane Cecilie Dæhli; Gudlaugsson, Einar (Peer reviewed; Journal article, 2021-12)
      Implementation of high-risk human papilloma virus (HPV) screening and the increasing proportion of HPV vaccinated women in the screening program will reduce the percentage of HPV positive women with oncogenic potential. ...
    • Homologous Recombination Deficiency Across Subtypes of Primary Breast Cancer 

      Yndestad, Synnøve; Engebrethsen, Christina; Herencia-Ropero, A.; Nikolaienko, Oleksii; Vintermyr, Olav Karsten; Lillestøl, Reidun Kristine; Minsaas, Laura; Leirvaag, Beryl; Iversen, Gjertrud Titlestad; Gilje, Bjørnar; Blix, Egil Støre; Espelid, Helge; Lundgren, Steinar; Geisler, Jürgen; Aase, Hildegunn Siv; Aas, Turid; Gudlaugsson, Einar; Llop-Guevara, Alba; Serra, Violeta; Janssen, Emiel; Lønning, Per Eystein; Knappskog, Stian; Eikesdal, Hans Petter (Peer reviewed; Journal article, 2023)
      Purpose Homologous recombination deficiency (HRD) is highly prevalent in triple-negative breast cancer (TNBC) and associated with response to PARP inhibition (PARPi). Here, we studied the prevalence of HRD in non-TNBC to ...
    • Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway 

      Helland, Åslaug; Russnes, Hege Elisabeth Giercksky; Fagereng, Gro Live; Al-Shibli, Khalid Ibrahim; Andersson, Yvonne; Berg, Thomas; Bjørge, Line; Blix, Egil Støre; Bjerkehagen, Bodil; Brabrand, Sigmund; CAMERON, MARTE; Dalhaug, Astrid; Dietzel, Dalia; Dønnem, Tom; Enerly, Espen; Flobak, Åsmund; Fluge, Sverre; Gilje, Bjørnar; Gjertsen, Bjørn Tore; Grønberg, Bjørn Henning; Grønås, Kari; Guren, Tormod Kyrre; Hamre, Hanne Mari; Haug, Åse; Heinrich, Daniel; Hjortland, Geir Olav; Hovig, Eivind; Hovland, Randi; Iversen, Ann-Charlotte; Janssen, Emiel; Kyte, Jon A; Gythfeldt, Hedda; Lothe, Ragnhild Adelheid; Lund, Jo-Åsmund; Meza, Leonardo Zepeda; Munthe-Kaas, Monica Cheng; Nguyen, Olav Toai Duc; Niehusmann, Pitt; Nilsen, Hilde; Puco, Katarina; Ree, Anne Hansen; Riste, Tonje Bøyum; Semb, Karin; Steinskog, Eli Sihn Samdal; Stensvold, Andreas; Suhrke, Pål; Tennøe, Øyvind Krohn; Tjønnfjord, Geir Erland; Vassbotn, Liv Jorunn; Aas, Eline; Aasebø, Kristine Øverås; Tasken, Kjetil; Smeland, Sigbjørn (Peer reviewed; Journal article, 2022)
      Background Matching treatment based on tumour molecular characteristics has revolutionized the treatment of some cancers and has given hope to many patients. Although personalized cancer care is an old concept, renewed ...
    • Influence of pre-operative oral carbohydrate loading vs. standard fasting on tumor proliferation and clinical outcome in breast cancer patients - a randomized trial 

      Lende, Tone Hoel; Austdal, Marie; Varhaugvik, Anne Elin; Skaland, Ivar; Gudlaugsson, Einar; Kvaløy, Jan Terje; Akslen, Lars A.; Søiland, Håvard; Janssen, Emiel; Baak, Jan P.A. (Journal article; Peer reviewed, 2019-11)
      Background Conflicting results have been reported on the influence of carbohydrates in breast cancer. Objective To determine the influence of pre-operative per-oral carbohydrate load on proliferation in breast ...
    • Invasive cancerous area detection in non-muscle invasive bladder cancer whole slide images 

      Fuster Navarro, Saul; Khoraminia, Farbod; Kiraz, Umay; Kanwal, Neel; Kvikstad, Vebjørn; Eftestøl, Trygve Christian; Zuiverloon, Tahlita C M; Janssen, Emiel; Engan, Kjersti (Chapter, 2022)
      Bladder cancer patients’ stratification into risk groups relies on grade, stage and clinical factors. For non-muscle invasive bladder cancer, T1 tumours that invade the subepithelial tissue are high-risk lesions with a ...
    • Low Z-4OHtam concentrations are associated with adverse clinical outcome among early stage premenopausal breast cancer patients treated with adjuvant tamoxifen 

      Helland, Thomas; Naume, Bjørn; Hustad, Steinar; Bifulco, Ersilia; Kvaløy, Jan Terje; Sætersdal, Anna Barbro; Synnestvedt, Marit; Lende, Tone Hoel; Gilje, Bjørnar; Mjaaland, Ingvil; Weyde, Kjetil; Blix, Egil Støre; Wiedswang, Gro; Borgen, Elin; Hertz, Daniel Louis; Janssen, Emiel; Mellgren, Gunnar; Søiland, Håvard (Peer reviewed; Journal article, 2020)
      Low steady‐state levels of active tamoxifen metabolites have been associated with inferior treatment outcomes. In this retrospective analysis of 406 estrogen receptor‐positive breast cancer (BC) patients receiving adjuvant ...
    • Melanoma Diagnosis and Localization from Whole Slide Images using Convolutional Neural Networks 

      Amundsen, Roger (Master thesis, 2022)
      During the last decade, no other cancer type in Norway have had higher increase in incidents than skin cancer. Melanoma is the most aggressive type of skin cancer because it has the ability to rapidly spread, which makes ...
    • Melanoma prognosis prediction using image processing and machine learning 

      Andreassen, Christopher (Master thesis, 2022)
      Death of melanoma cancer is most common in Europe, and northern Europe has the second highest mortality rate of melanoma in the world, with 1.9 per 100 000 dying from melanoma in northern Europe in 2020. Prognosis of ...
    • Metabolic consequences of perioperative oral carbohydrates in breast cancer patients - an explorative study 

      Lende, Tone Hoel; Austdal, Marie; Bathen, Tone Frost; Varhaugvik, Anne Elin; Skaland, Ivar; Gudlaugsson, Einar; Egeland, Nina Gran; Lunde, Siri; Akslen, Lars A.; Jonsdottir, Kristin; Janssen, Emiel; Søiland, Håvard; Baak, Jan P.A. (Journal article; Peer reviewed, 2019-12)
      Background The metabolic consequences of preoperative carbohydrate load in breast cancer patients are not known. The present explorative study investigated the systemic and tumor metabolic changes after preoperative ...
    • MiR-18a and miR-18b are expressed in the stroma of oestrogen receptor alpha negative breast cancers 

      Egeland, Nina Gran; Jonsdottir, Kristin; Aure, Miriam Ragle; Sahlberg, Kristine Kleivi; Kristensen, Vessela N.; Cronin-Fenton, Deirdre; Skaland, Ivar; Gudlaugsson, Einar; Baak, Jan P.A.; Janssen, Emiel (Peer reviewed; Journal article, 2020-05)
      Background Previously, we have shown that miR-18a and miR-18b gene expression strongly correlates with high proliferation, oestrogen receptor -negativity (ER−), cytokeratin 5/6 positivity and basal-like features of breast ...
    • miRNA normalization enables joint analysis of several datasets to increase sensitivity and to reveal novel miRNAs differentially expressed in breast cancer 

      Ben-Elazar, Shay; Aure, Miriam Ragle; Jonsdottir, Kristin; Leivonen, Suvi-Katri; Kristensen, Vessela N.; Janssen, Emiel; Sahlberg, Kristine Kleivi; Lingjærde, Ole Christian; Yakhini, Zohar (Peer reviewed; Journal article, 2021-02)
      Different miRNA profiling protocols and technologies introduce differences in the resulting quantitative expression profiles. These include differences in the presence (and measurability) of certain miRNAs. We present and ...