• Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease 

      Dölle, Christian; Flønes, Irene Hana; Sanchez Nido, Gonzalo; Miletic, Hrvoje; Osuagwu, Nelson; Kristoffersen, Stine; Lilleng, Peer Kåre; Larsen, Jan Petter; Tysnes, Ole-Bjørn; Haugarvoll, Kristoffer; Bindoff, Laurence; Tzoulis, Charalampos (Journal article; Peer reviewed, 2016-11)
      Increased somatic mitochondrial DNA (mtDNA) mutagenesis causes premature aging in mice, and mtDNA damage accumulates in the human brain with aging and neurodegenerative disorders such as Parkinson disease (PD). Here, we ...
    • Falls in Parkinson's disease 

      Hiorth, Ylva Hivand (PhD thesis UiS;325, Doctoral thesis, 2016-12-20)
      Background Parkinson's disease (PD) is a slowly progressive neurodegenerative disorder affecting 1% of the population over 60 years. Although motor abnormalities are the core feature of the disease, PD is today considered ...